Primary versus Secondary Ovarian Malignancy: Imaging Findings of Adnexal Masses in the Radiology Diagnostic Oncology Group Study

Brown, Douglas L.; Zou, Kelly H.; Tempany, Clare M.; Frates, Mary C.; Silverman, Stuart G.; McNeil, Barbara J.; Kurtz, Alfred B.

doi:10.1148/radiology.219.1.r01ap28213

Cited by 144 publications

(96 citation statements)

References 20 publications

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“…When increased FDG uptake is seen simultaneously in the ovary and other organs, such as the stomach or colon, on PET/CT images, MOTs are the most likely culprit, as opposed to primary ovarian tumors. Additionally, because the imaging findings of MOTs according to primary tumor site are known (Brown et al 2001;Choi et al 2005;Koyama et al 2007), use of the CT portion of PET/CT combined with FDG uptake analysis can assist differentiation of MOTs from primary ovarian tumors.…”

Section: Discussionmentioning

confidence: 99%

F-18 FDG PET/CT findings of metastatic ovarian tumors from gastrointestinal tract origin

Park

Yoo

et al. 2015

J Cancer Res Clin Oncol

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Section: Discussionmentioning

confidence: 99%

F-18 FDG PET/CT findings of metastatic ovarian tumors from gastrointestinal tract origin

Park

Yoo

et al. 2015

J Cancer Res Clin Oncol

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“…In general, imaging reports have suggested that most metastatic neoplasms are predominantly solid or a mixture of cystic and solid areas. However, in a comprehensive study, Brown et al (10) reported neither predominantly solid appearance nor bilateral ovarian involvement to be significantly different between primary and secondary neoplasms. The imaging characteristics depend on the primary tumor.…”

Section: Historymentioning

confidence: 98%

Case 210: Primary Ovarian Lymphoma

Chien¹,

Chen²,

Chan³

2014

Radiology

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Abdominopelvic CT scans showed solid masses involving both ovaries (Fig 1a). Both ovaries were abnormally enlarged; the right ovary measured 16 3 10 3 11 cm, and the left ovary measured 6.2 3 3.7 3 5.3 cm. Both ovaries contained low-attenuation cysts displaced toward the periphery by an infiltrating soft-tissue tumor (Fig 1b, 1c). The infiltrating mass encased the right gonadal vessels (Fig 1d) from the hilum of the ovary (Fig 2) to the retroperitoneum; however, the vessels were not occluded. These findings were confirmed with subsequent surgery and histologic analysis (Fig 3). A few ascites in the peritoneal cavity were noted; however, there was no evidence of splenomegaly. No other mass lesion was detected in the abdomen or pelvis.A provisional diagnosis of ovarian tumor was made, and the patient underwent total abdominal hysterectomy, bilateral salpingooophorectomy, omentectomy, paraaortic lymph node dissection, and lavage for cytology. The diagnosis at pathology was primary ovarian lymphoma, diffuse large B-cell type. Bone marrow biopsy findings were negative. Chest CT findings also were negative. The patient underwent chemotherapy, and no tumor recurrence was noted during 1 year of follow-up.

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“…For adnexal masses that appear complex or possibly malignant on US, magnetic resonance (MR) imaging adds significant further information, with a reported accuracy as high as 91% [4,[6][7][8]. In this specific setting, some criteria are highly suggestive for benign ovarian lesions (e.g., fatty components, shading on T2-weighted images) [9,10], whereas vegetations and solid portions within cystic masses have been shown to be the best predictors of malignancy [7,11]. Using these different criteria, a preliminary diagnosis can be made before surgery.…”

Section: Introductionmentioning

confidence: 99%

MR imaging compared with intraoperative frozen-section examination for the diagnosis of adnexal tumors; correlation with final histology

et al. 2006

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The aim was to compare the accuracy of magnetic resonance imaging (MRI) and intraoperative consultation (IC) for the diagnosis of adnexal masses, with reference to final histology. MRI was performed in 136 women with sonographically indeterminate adnexal masses. IC included macroscopic and frozen-section examination. Macroscopic examination and MRI determined size, nature, and presence of vegetations or solid portions within masses. All masses were characterized as benign or malignant according to previously published MR imaging and histopathologic criteria. Sensitivities, specificities, and predictive values for the diagnosis of malignancy of MRI and IC were assessed. Histology revealed 168 adnexal masses (99 benign, 23 borderline and 46 invasive). Frozen sections were examined in 151 cases. Among the 151 adnexal masses studied by both MRI and IC, respective sensitivities, specificities, positive and predictive values of both methods for the diagnosis of malignancy were 89.7% and 84.5%, 91.4% and 100%, 86.7% and 100%, and 93.4% and 91.3%. Sensitivities of MR imaging and frozen section for the diagnosis of serous versus mucinous borderline tumors were 33.3% and 93.3%, and 62.5% and 12.5%, respectively. MRI is less accurate than IC for characterizing adnexal masses. However, MRI may increase the relevance of IC for borderline mucinous tumors.

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Primary versus Secondary Ovarian Malignancy: Imaging Findings of Adnexal Masses in the Radiology Diagnostic Oncology Group Study

Abstract: For malignant ovarian masses, multilocularity at MR imaging or US favors the diagnosis of primary ovarian malignancy rather than secondary neoplasm, but it is difficult to accurately distinguish between primary and secondary ovarian malignancies.

Cited by 144 publications

References 20 publications

F-18 FDG PET/CT findings of metastatic ovarian tumors from gastrointestinal tract origin

F-18 FDG PET/CT findings of metastatic ovarian tumors from gastrointestinal tract origin

Case 210: Primary Ovarian Lymphoma

MR imaging compared with intraoperative frozen-section examination for the diagnosis of adnexal tumors; correlation with final histology

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