Primary Yolk Sac Tumor of the Prostate: A Case Report and Review of the Literature

Furr, J. R.; Mellis, Adamantios M.; Slobodov, Gennady

doi:10.1159/000371660

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…YST can occur anywhere along the midline. From a urogenital pathology perspective, involvement of the renal pelvis [ 6 ], prostate [ 12 ], seminal vesicle [ 13 ], bladder [ 14 , 15 ], and retroperitoneum [ 5 ] is known. YSTs are highly aggressive tumors that can metastasize lymphatically and hematogenously.…”

Section: Discussionmentioning

confidence: 99%

Urachal yolk sac tumor penetrating the bladder as a diagnostic challenge: a case report and review of the literature

et al. 2022

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Background Yolk sac tumor (YST) is a germ cell tumor. It is primarily located in the gonads but can also occur extragonadally (extragonadal yolk sac tumor - EGYST), most commonly in the pelvis, retroperitoneum or mediastinum. Only a few YSTs of the urachus have been described. Case report We present a rare case report of a 37-year-old male with episodes of macroscopic hematuria. The histological specimen obtained by transurethral resection showed a solid, and in some parts papillary infiltrative, high-grade tumor with numerous areas of marked nuclear atypia and clear invasion between the detrusor bundles. Glandular pattern has been observed in only minority of the tumor. Immunohistochemistry showed significant positivity for GPC3, SALL4 and cytokeratins AE1/AE3, while KRT7 and GATA3 were negative. We concluded that the biopsy findings were consistent with urothelial carcinoma with infrequent YST differentiation. In definitive surgical specimens we found a malignant epithelial, glandular and cystically arranged tumor of germinal appearance arising from urachus. The surrounding urothelium was free of invasive or in situ tumor changes. We reclassified the tumor as a urachal YST. Conclusion EGYST was suspected because glandular and hepatoid structures were found, but the presence of these structures should be verified by immunohistochemistry.

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Section: Discussionmentioning

confidence: 99%

Urachal yolk sac tumor penetrating the bladder as a diagnostic challenge: a case report and review of the literature

et al. 2022

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“…2 The extragonadal YSTs could occur in the midline structures of the body from the pineal gland to the coccyx, such as central nervous system, mediastinum, retroperitoneum, and coccyx. [3][4][5][6][7] The mediastinal YST is extremely rare, which represents only 1% to 4% of all malignant mediastinal tumors. 8 AFP, produced by YST lesions, is considered to be a useful marker to follow up the progression of YSTs.…”

Section: Figurementioning

confidence: 99%

Occult Mediastinal Yolk Sac Tumor Producing α-Fetoprotein Detected by 18F-FDG PET/CT

Chen

et al. 2016

Clinical Nuclear Medicine

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“…Extragonadal yolk sac tumours (ysts), like other extragonadal germ cell tumours, are rare malignant neoplasms that typically arise in the sacrococcygeal, mediastinal, retroperitoneal, and head-and-neck regions 2 . Only 8 cases of primary prostatic ysts have been reported in the literature [3][4][5][6][7][8][9][10] . Because of their extreme rarity, low index of clinical suspicion, and broad spectrum of morphologic patterns, prostatic ysts pose a diagnostic pitfall.…”

Section: Introductionmentioning

confidence: 99%

Primary Yolk Sac Tumour of the Prostate Mimicking Small Round Blue Cell Tumour

et al. 2019

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Prostatic yolk sac tumour is a germ cell tumour with a wide range of age of occurrence, unusual anatomic locations, diverse morphologic patterns, and aggressive biologic behavior, posing challenges both to diagnosis and clinical management. We report a rare case of primary yolk sac tumour of the prostate with extensive local and liver metastasis, the latter of which exhibited sheets of small blue cells expressing CD99 and focal sall4 on biopsy. Positivity for CD99 and gata3 in the initial biopsy raised the differential diagnosis of Ewing sarcoma and poorly differentiated carcinoma. The primary tumour demonstrated an admixture of solid and glandular growth patterns and occasional Schiller–Duval bodies. A panel of immunohistochemical stains showing positivity for AE1/3, sall4, cdx2, and focal alpha-fetoprotein, and negativity for oct-4, facilitated the diagnosis. A thorough review of the literature and our current report indicate that a large tumour load, incomplete tumour resection, limited response to preoperative neoadjuvant chemotherapy, and late stage of the disease are predictive factors for a poor clinical outcome.

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Primary Yolk Sac Tumor of the Prostate: A Case Report and Review of the Literature

Cited by 8 publications

References 10 publications

Urachal yolk sac tumor penetrating the bladder as a diagnostic challenge: a case report and review of the literature

Urachal yolk sac tumor penetrating the bladder as a diagnostic challenge: a case report and review of the literature

Occult Mediastinal Yolk Sac Tumor Producing α-Fetoprotein Detected by 18F-FDG PET/CT

Primary Yolk Sac Tumour of the Prostate Mimicking Small Round Blue Cell Tumour

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