Primed status of transitional B cells associated with their presence in the cerebrospinal fluid in early phases of multiple sclerosis

Lee-Chang, Catalina; Top, Isabelle; Zephir, Hélène; Dubucquoi, Sylvain; Trauet, Jacques; Dussart, Patricia; Prin, Lionel; Vermersch, Patrick

doi:10.1016/j.clim.2010.11.004

Cited by 22 publications

(26 citation statements)

References 44 publications

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“…Trafficking of B cells may be an early disease step, as CIS patients have higher levels of VLA-4 on their transitional B cells than is observed in MS patients. 69 Such an initial step would enable B cells to enter the CNS, encounter their autoantigen and undergo germinal center-like reactions as evidenced by SHM accumulation and altered selection of VH genes.…”

Section: Discussionmentioning

confidence: 99%

Expansion of CD27high plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation

et al. 2013

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Patients with the autoimmune disease multiple sclerosis (MS) typically present with the clinically isolated syndromes (CIS) transverse myelitis (TM) or optic neuritis (ON). B-cell disturbances have been well documented in patients with MS and CIS patients with ON, but not in CIS patients with TM, despite the fact that these patients have the worst clinical outcome of all CIS types. The goal of this study was to characterize the B-cell populations and immunoglobulin genetics in TM patients. We found a unique expansion of CD27high plasmablasts in both the cerebrospinal fluid and periphery of TM patients that is not present in ON patients. Additionally, plasmablasts from TM patients show evidence for positive selection with increased somatic hypermutation accumulation in VH4+ B cells and receptor editing that is not observed in ON patients. These characteristics unique to TM patients may impact disease severity and progression.

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Section: Discussionmentioning

confidence: 99%

Expansion of CD27high plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation

et al. 2013

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“…Centroblasts, typically found in the germinal centre of lymphatic tissue, were also detected in the CSF of MS patients, suggesting intrathecal production [90]. Transitional alterations of B-cells in early MS stages, like overexpression of CD80(+), α 4, and β 1 integrins, are associated with their ability to cross BBB [91]. The expression of α 4 integrin in B-cells was correlated with the number of gadolinium-enhanced lesions, during CIS [92].…”

Section: Laboratorial Biomarkersmentioning

confidence: 99%

Biomarkers in Multiple Sclerosis: An Up-to-Date Overview

Katsavos

Anagnostouli

2013

Multiple Sclerosis International

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During the last decades, the effort of establishing satisfactory biomarkers for multiple sclerosis has been proven to be very difficult, due to the clinical and pathophysiological complexities of the disease. Recent knowledge acquired in the domains of genomics-immunogenetics and neuroimmunology, as well as the evolution in neuroimaging, has provided a whole new list of biomarkers. This variety, though, leads inevitably to confusion in the effort of decision making concerning strategic and individualized therapeutics. In this paper, our primary goal is to provide the reader with a list of the most important characteristics that a biomarker must possess in order to be considered as reliable. Additionally, up-to-date biomarkers are further divided into three subgroups, genetic-immunogenetic, laboratorial, and imaging. The most important representatives of each category are presented in the text and for the first time in a summarizing workable table, in a critical way, estimating their diagnostic potential and their efficacy to correlate with phenotypical expression, neuroinflammation, neurodegeneration, disability, and therapeutical response. Special attention is given to the “gold standards” of each category, like HLA-DRB1∗ polymorphisms, oligoclonal bands, vitamin D, and conventional and nonconventional imaging techniques. Moreover, not adequately established but quite promising, recently characterized biomarkers, like TOB-1 polymorphisms, are further discussed.

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“…There is a significant accumulation of memory B-cells in or near the diseased organs of patients with RA [148] and MS [149,150]. As EBV resides in latently infected memory B-cells, such accumulations increase the probability that EBV will be present and exposed to the local inflammatory environment.…”

Section: Viral Mechanismsmentioning

confidence: 99%

Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation

Lossius

Johansen

Torkildsen

et al. 2012

Viruses

116

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Epidemiological data suggest that the Epstein-Barr virus (EBV) is associated with several autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis. However, it is not clear whether EBV plays a role in the pathogenesis of these diseases, and if so, by which mechanisms the virus may contribute. In this review, we discuss possible viral and immunological mechanisms that might explain associations between EBV and autoimmune diseases and whether these associations represent causes or effects of inflammation and autoimmunity.

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Primed status of transitional B cells associated with their presence in the cerebrospinal fluid in early phases of multiple sclerosis

Cited by 22 publications

References 44 publications

Expansion of CD27high plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation

Expansion of CD27high plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation

Biomarkers in Multiple Sclerosis: An Up-to-Date Overview

Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation

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