Primidone is associated with interictal depression in patients with epilepsy

López-Gómez, Mario; Ramı́rez-Bermúdez, Jesús; Campillo, Carlos; Sosa, Ana Luisa; Espínola, Moisés; Ruíz, Isabel

doi:10.1016/j.yebeh.2005.01.016

Cited by 32 publications

(18 citation statements)

References 17 publications

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“…In our study, anxiety was not associated with temporal lobe epilepsy, and the only medication associated with anxiety among our patients was primidone, fact that could be related to their association with depression, described before (Lopez-Gomez et al 2005). However, the design of the study does not allow us to determine the influence of antiepileptic medication in the outcome of our study.…”

Section: Discussionsupporting

confidence: 68%

Clinical presentation of anxiety among patients with epilepsy

López-Gómez

Espínola²,

Ramı́rez-Bermúdez³

et al. 2008

NDT

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Different factors have been related with interictal anxiety, reported in 10%-25% of patients with epilepsy. We determined the frequency of interictal anxiety in 196 patients with active epilepsy in a cross-sectional survey to know which symptoms of anxiety were most frequently reported in patients with epilepsy and to analyze the factors associated with their presence. Patients were assessed with the Beck Depression Inventory (BDI), MontgomeryAsberg Depression Rating Scale (MADRS), and the Hamilton Anxiety Scale (HAMA). Data were analyzed with a logistic regression model. The HAMA ratings revealed that 38.8% experienced signifi cant anxiety symptoms, as defi ned by a rating above 18 points. Use of primidone, depression, cryptogenic, and posttraumatic etiologies signifi cantly predicted anxiety after logistic regression. Symptoms related to higher scores on HAMA were anxious mood, tension, insomnia, intellectual function, depressed mood, cardiovascular and genitourinary symptoms. Further studies should be performed to defi ne the role of psychosocial factors in the development and evolution of anxiety among these patients.

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Section: Discussionsupporting

confidence: 68%

Clinical presentation of anxiety among patients with epilepsy

López-Gómez

Espínola²,

Ramı́rez-Bermúdez³

et al. 2008

NDT

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“…It is possible that any of these medications could affect mood. [41][42][43][44] Our study did not control the antidepressant use across groups. Dosage of drugs, the course of treatment and the percentage of patients on antidepressants were different between two groups.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of depressive symptoms in essential tremor

Xie

Tian

et al. 2011

Journal of Clinical Neuroscience

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“…Compounds such as phenobarbital, primidone, topiramate, and vigabatrin are often associated with depressive responses (McConnell and Duncan 1998;Lopez-Gomez et al 2005). Even LTG, which is well known for its depressolytic properties, has been reported to be associated with depression in some cases (Kanner and Palac 2000).…”

Section: Fig 3 Correlation Between Baq and Ids-sr Scoresmentioning

confidence: 99%