Priming of microglia with dysfunctional gut microbiota impairs hippocampal neurogenesis and fosters stress vulnerability of mice

He, Hui; He, Haili; Mo, Li; You, Zili; Zhang, Jinqiang

doi:10.1016/j.bbi.2023.10.031

Cited by 13 publications

(3 citation statements)

References 69 publications

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“…CRD is prevalent in modern society among people of all ages, shift work or jet lag increases the risk of neurodegenerative disorders, psychiatric disorders and gastrointestinal diseases [45,[67][68][69]]. In addition, animal studies have yielded similar results [70][71][72].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, microglial activation is observed in the contexts of aging, in ammation, and neurodegenerative disorders, all of which are associated with detrimental effects on cognitive function [43,44]. LPS in circulation can activate microglia by crossing the blood-brain barrier (BBB) [45].…”

Section: Gut In Ammation Associated With Crd Can Have Effects Via The...mentioning

confidence: 99%

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Disruption of the Circadian Rhythm Is Exacerbated by Aging and Ameliorated by Time- restricted Feeding

Huo,

Liu,

et al. 2024

Preprint

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Background: Circadian rhythms exist across species, and circadian rhythm disorder (CRD) occurs in people of all ages and is prevalent in those with age-related neurodegenerative diseases. The gut microbiota changes with age and a significant proportion of gut microbes show circadian rhythms in their homeostasis. Dysregulation of gut microbial homeostasis is likewise a neurodegenerative disease trigger. Results: In this study, to investigate the relationship between aging, CRD, and the gut microbes, we created a model of CRD by controlling the light/dark cycle, and found that aging aggravated their cognitive impairment and mood disorders. This was accompanied by a loss of gut microbial homeostasis, impairment of the intestinal barrier, and systemic inflammation in aged mice with CRD. The abnormal expression pattern of circadian genes underpin the age-related expression pattern of ifi27l2, thereby exacerbating oxidative stress. In addition, time-restricted feeding (TRF) ameliorated the negative effects of CRD in aged mice by enriching Akkermansia_muciniphilaand inhibiting the NOD-like signaling pathway. Conclusion: Aged mice show more severe impairments in response to stress, likely due to inflammation from gut microbes and circadian gene dysregulation. Maintaining a regular eating schedule can help reduce these effects.

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Section: Discussionmentioning

confidence: 99%

Section: Gut In Ammation Associated With Crd Can Have Effects Via The...mentioning

confidence: 99%

Disruption of the Circadian Rhythm Is Exacerbated by Aging and Ameliorated by Time- restricted Feeding

Huo,

Liu,

et al. 2024

Preprint

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“…Activated microglia could produce inflammatory cytokines, and chronic neuroinflammation can impair neurons and cause neurocognitive function. 37 To determine whether microglia activation triggered neuron damage and neuroinflammation, we first measured levels of brain inflammatory cytokines. Figure 5A illustrates the expression of proinflammatory factors in the cerebral cortex.…”

Section: Otp Suppressed the Production Of Proinflammatory Mediators A...mentioning

confidence: 99%

Gut Microbiota Mediate the Neuroprotective Effect of Oolong Tea Polyphenols in Cognitive Impairment Induced by Circadian Rhythm Disorder

Song,

Ho,

Zhang

2024

J. Agric. Food Chem.

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Oolong tea polyphenols (OTP) have attracted wide attention due to their ability to reduce inflammatory response, regulate gut microbiota, and improve cognitive function. However, exactly how the gut microbiota modulates nervous system activity is still an open question. We previously expounded that supplementing with OTP alleviated neuroinflammation in circadian rhythm disorder (CRD) mice. Here, we showed that OTP can relieve microglia activation by reducing harmful microbial metabolites lipopolysaccharide (LPS) that alleviate CRD-induced cognitive decline. Mechanistically, OTP suppressed the inflammation response by regulating the gut microbiota composition, including upregulating the relative abundance of Muribaculaceae and Clostridia_UCG-014 and downregulating Desulfovibrio, promoting the production of short-chain fatty acids (SCFAs). Moreover, the use of OTP alleviated intestinal barrier damage and decreased the LPS transport to the serum. These results further inhibited the activation of microglia, thus alleviating cognitive impairment by inhibiting neuroinflammation, neuron damage, and neurotoxicity metabolite glutamate elevation. Meanwhile, OTP upregulated the expression of synaptic plasticity-related protein postsynaptic density protein 95 (PSD-95) and synaptophysin (SYN) by elevating the brain-derived neurotrophic factor (BDNF) level. Taken together, our findings suggest that the OTP has the potential to prevent CRD-induced cognition decline by modulating gut microbiota and microbial metabolites.

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The Role of the Intestinal Flora and Its Derivatives in Neurocognitive Disorders: A Narrative Review from Surgical Perspective

Huang,

Qin,

et al. 2024

Mol Neurobiol

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Perioperative neurocognitive dysfunction is a significant concern for population health, impacting postoperative recovery and increasing the financial burden on patients. With an increasing number of surgical procedures being performed, the prevention and management of perioperative neurocognitive dysfunction have garnered significant attention. While factors such as age, lifestyle, genetics, and education are known to influence the development of cognitive dysfunction, recent research has highlighted the role of the gut microbiota in neurological health. An increased abundance of pro-inflammatory gut microbiota can trigger and worsen neuroinflammation, neuronal cell damage, and impaired cellular autophagy. Moreover, the inflammation-promoting gut microbiota can disrupt immune function, impair neuroautophagy, and affect the production and circulation of extracellular vesicles and neurotransmitters. These factors collectively play a role in the onset and advancement of cognitive impairment. This narrative review delves into the molecular mechanisms through which gut microbiota and their derivatives contribute to cognitive impairment, focusing on the impact of anesthesia surgery, changes in gut microbial populations, and perioperative cognitive impairment associations. The study suggests that alterations in the abundance of various bacterial species and their metabolites pre- and post-surgery may be linked to postoperative cognitive impairment. Furthermore, the potential of probiotics or prebiotics in addressing cognitive impairment is discussed, offering a promising avenue for investigating the treatment of perioperative neurocognitive disorders.

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Priming of microglia with dysfunctional gut microbiota impairs hippocampal neurogenesis and fosters stress vulnerability of mice

Cited by 13 publications

References 69 publications

Disruption of the Circadian Rhythm Is Exacerbated by Aging and Ameliorated by Time- restricted Feeding

Disruption of the Circadian Rhythm Is Exacerbated by Aging and Ameliorated by Time- restricted Feeding

Gut Microbiota Mediate the Neuroprotective Effect of Oolong Tea Polyphenols in Cognitive Impairment Induced by Circadian Rhythm Disorder

The Role of the Intestinal Flora and Its Derivatives in Neurocognitive Disorders: A Narrative Review from Surgical Perspective

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