Priming prevent nephrotoxic acute renal failure through stimulation of antioxidant defense mechanism

Duarte, Fernanda; Pessoa, Edson Andrade; Reis, Luciana Aparecida; Schor, Nestor; Borges, Fernanda Teixeira

doi:10.5935/0101-2800.20160025

Cited by 6 publications

(1 citation statement)

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“…In this study, significantly upregulated mRNA expression of the HO-1 enzyme was observed in GMtreated rats in addition to an increase in HO-1 expression following supplementation with n-3 PUFA. It has been suggested that GM treatment induces a state of stress in cells by creating an inflammatory environment that may encourage expression of the HO-1 protein as a stress response (Duarte et al 2016, Aycan-Ustyol et al 2017, Park et al 2017). On the other hand, recent in vivo and in vitro studies postulated the ability of n-3 PUFA to induce HO-1 expression through direct activation of its upstream Nrf2 regulator gene (Qi et al 2017, Sakai et al 2017, Tatsumi et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Omega-3 polyunsaturated fatty acids confer protection against gentamicin-induced testicular injury: Novel insights into possible mechanisms

Abdelhaffez¹,

Hussein²,

Rateb³

et al. 2019

J. Physiol. Pathophysiol.

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Gentamicin (GM) is an aminoglycoside that has harmful effects on the male germ cells and sperm quality. N-3 polyunsaturated fatty acids (n-3 PUFA) are natural antioxidants that influence cell signaling and inflammation. Heme-oxygenase-1 (HO-1) and heat shock proteins (HSP) aid in cellular protection against cellular insults. This study aimed to explore the potential alleviating influences of treatment with n-3 PUFA on GM-induced testicular damage. Thirty-two albino male rats were divided into four equal groups. (1) The control group received normal saline, (2) the n-3 PUFA group received 100 mg/kg body weight/day n-3 PUFA daily for 4 weeks, (3) the GM group received 100 mg/kg/day GM intraperitoneally for 10 consecutive days, and (4) the GM + n-3 PUFA group received intraperitoneal GM for ten days followed by treatment with n-3 PUFA for 4 weeks. Significant reductions in sperm motility, viability, serum testosterone, total testicular protein, and germinal epithelium height were observed in the GM-treated group, with upregulation of the oxidative stress markers, HO-1 mRNA, and HSP70, and downregulation of proliferating cell nuclear antigen (PCNA). We also observed cellular disorganization, vacuolation, tubular distortion, and a significantly higher percentage of collagen. Ultra-structurally, most of the spermatogenic cells were electron dense and degenerated with rarefied cytoplasm. Treatment with n-3 PUFA resulted in a significant increase in sperm motility, viability, serum testosterone, and in the germinal epithelium height. Upregulation of HO-1 mRNA, HSP70, and PCNA expression and a significant reduction in the oxidative stress index were also observed. The findings confirm the potential ameliorative role of and imply novel mechanisms by which n-3 PUFA protects against GM-induced testicular injury.

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Section: Discussionmentioning

confidence: 99%

Omega-3 polyunsaturated fatty acids confer protection against gentamicin-induced testicular injury: Novel insights into possible mechanisms

Abdelhaffez¹,

Hussein²,

Rateb³

et al. 2019

J. Physiol. Pathophysiol.

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Baicalin-2-ethoxyethyl ester alleviates gentamicin-induced acute kidney injury via NF-κB signaling pathway

Chen,

Zhang,

Cui

et al. 2024

Biomedicine & Pharmacotherapy

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The role of preconditioning in the development of resilience: Mechanistic insights

Holcombe

Weavers

2022

Current Opinion in Toxicology

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Priming prevent nephrotoxic acute renal failure through stimulation of antioxidant defense mechanism

Abstract: Priming is a persistent and multifactorial mechanism, the stimulation of the antioxidant defense could mimics partially the priming process and prevent the ARF.

Cited by 6 publications

References 0 publications

Omega-3 polyunsaturated fatty acids confer protection against gentamicin-induced testicular injury: Novel insights into possible mechanisms

Omega-3 polyunsaturated fatty acids confer protection against gentamicin-induced testicular injury: Novel insights into possible mechanisms

Baicalin-2-ethoxyethyl ester alleviates gentamicin-induced acute kidney injury via NF-κB signaling pathway

The role of preconditioning in the development of resilience: Mechanistic insights

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