Priming With Alcuronium and Tubocurarine Accelerates the Onset of Neuromuscular Block †

Pollard, B. J.

doi:10.1093/bja/63.1.7

Cited by 7 publications

(1 citation statement)

References 21 publications

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“…Evoked electromyographic (EEMG) monitoring of neuromuscular function is unreliable in 5-42% of patients because the first response (Tl) to train-offour (TOF) stimulation does not return to the preblock baseline value during the offset of neuromuscular block [1][2][3]. A decrease in the Tl response of the EEMG also occurs during the first 15-20 min of general anaesthesia without neuromuscular blocking agents [4][5][6], but not in awake volunteers [7].…”

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Influence of serum concentrations of catecholamines and i.v. or volatile anaesthesia on evoked electromyography in the hand

Smith

Hope

1994

British Journal of Anaesthesia

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We have examined the correlation between serum concentrations of catecholamines and the evoked electromyographic (EEMG) response from the first dorsal interosseous muscle of the hand in 20 patients during minor surgery under propofol or enflurane anaesthesia without neuromuscular blocking drugs. The supinated forearm, with the wrist fully extended, was strapped firmly to an armboard and immobilized with adhesive tape. In the propofol group, the mean EEMG response to the first stimulus in the train-of-four (T1) decreased to 83.0% (95% confidence intervals (CI) 78.7-87.3%) of baseline, while in the enflurane group the mean EEMG T1 response decreased to 84.0% (95% CI 81.6-86.4%) of baseline. The decrease in the EEMG response occurred over 20 min and did not correlate with plasma concentrations of adrenaline or noradrenaline (correlation coefficients all < 0.26). We conclude that the decrease in EEMG response during the first 30 min of anaesthesia occurred during both i.v. and inhalation anaesthesia, and that changes in plasma concentrations of catecholamines did not cause the decrease in the EEMG response.

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