Primitive Neuroectodermal Tumor and Extraskeletal Ewing Sarcoma Arising Primarily Around the Spinal Column

Harimaya, Katsumi; Oda, Yoshinao; Matsuda, Shinya; Tanaka, Kazuhiro; Chuman, Hirokazu; Iwamoto, Yukihide

doi:10.1097/01.brs.0000085099.47800.df

Cited by 73 publications

(86 citation statements)

References 29 publications

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“…Of 28 cases for whom follow-up data were available, 11 cases died after an average of 19 months, and 17 cases lived for an average of 27 months (range: 3-120 months). A diagnosis of EES tends to be late due to its rarity and the tumor being found after becoming massive (19). Furthermore, 20 of 26 cases (77%) were only partially resected due to infiltration of the surrounding nerve tissues.…”

Section: Discussionmentioning

confidence: 99%

“…The most common sites are the chest wall, paravertebral muscles, extremities, buttocks, and retroperitoneal space (3), but involvement of the epidural space is uncommon. To date, the number of reported cases of EES arising from the epidural space remains small (2,(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). An additional case of epidural EES is reported, and the literature on epidural EES is reviewed.…”

Section: Introductionmentioning

confidence: 99%

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Extraskeletal Ewing's sarcoma of the thoracic epidural space: Case report and review of the literature

Yasuda

2011

Oncol Rep

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Abstract. The occurrence of primary extraskeletal Ewing's sarcoma (EES) of the spinal epidural space has been rarely reported in the literature. The clinical, radiologic and pathologic features of a case of EES occurring in the thoracic epidural space are presented. A 37-year-old woman presented with a one-year history of back pain. Magnetic resonance imaging demonstrated an epidural mass at the T8-9 level. Laminectomy and partial resection of the tumor were performed. The differential diagnosis of a spinal epidural mass is broad. Histopathological and molecular cytogenetic examinations confirmed an EES arising from the thoracic epidural space. Despite receiving both chemotherapy and radiotherapy, the patient died of respiratory insufficiency due to medulla oblongata metastasis 22 months after the initial consultation. Awareness of this entity will allow this rare diagnosis to be considered and facilitate appropriate management. A review of the literature on spinal epidural EES is also presented.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extraskeletal Ewing's sarcoma of the thoracic epidural space: Case report and review of the literature

Yasuda

2011

Oncol Rep

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“…The male-female relationship is 1.5:1 in spinal epidural EES resembles that of bone (Figure 1-5). [17][18][19][20][21][22][23][24][25][26] The most common presentation is back pain, radicular pain, and paresis of unilateral or bilateral limbs, sensory disturbances, and bladder dysfunction. All these symptoms are related to compression of the cord, nerve roots and cauda equine as seen with other epidural tumors.…”

Section: Discussionmentioning

confidence: 99%

Pediatric Epidural Extra-Osseous Ewing’s Sarcoma - Extremely Rare Case Report and Review of the Literature

Gopinath

Moorthy

et al. 2017

IJRRT

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“…They rarely have an extraosseous origin. Based upon reports in the literature, it is exceptionally rare to fi nd them originating primarily within the spinal epidural space; only 34 such cases have been reported to date [1,5,[7][8][9][10]. Most patients are between 10 and 20 years old and male.…”

Section: Introductionmentioning

confidence: 99%

Primary Extraskeletal Ewing Sarcoma of the Thoracic Spinal Epidural Space: A Case Report

Yamamoto

Washimi

Ishimura

et al. 2007

Clinical medicine. Oncology

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Cases of extraskeletal Ewing sarcoma (EES) originating primarily within the spinal epidural space, are very rare and have a very poor prognosis. There is no standard therapy for this disease.We report the case of a 23-year-old man presenting with symptoms of back pain and numbness of both legs for 10 days. Imaging studies revealed a dorsal soft-tissue, extradural mass at the T8-9 vertebral level. The patient underwent a laminectomy and complete excision of the tumor. The EES diagnosis was confi rmed by histologic analysis including immunohistochemistry and by presence of the EWS-ERG due to the t (21: 22) (q22: q12) chromosomal translocation by a reverse transcriptase-polymerase chain reaction (RT-PCR). This is the fi rst report of spinal epidural EES with presence of the EWS-ERG fusion transcript. Postoperatively, the patient received aggressive adjuvant chemotherapy and radiotherapy.At 63 months after surgery, the patient is without clinical or radiological evidence of recurrent or metastatic disease. Early discovery of EES and a complete resection followed by the aggressive treatment with radiation and chemotherapy may improve disease-free and overall survival.

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Primitive Neuroectodermal Tumor and Extraskeletal Ewing Sarcoma Arising Primarily Around the Spinal Column

Cited by 73 publications

References 29 publications

Extraskeletal Ewing's sarcoma of the thoracic epidural space: Case report and review of the literature

Extraskeletal Ewing's sarcoma of the thoracic epidural space: Case report and review of the literature

Pediatric Epidural Extra-Osseous Ewing’s Sarcoma - Extremely Rare Case Report and Review of the Literature

Primary Extraskeletal Ewing Sarcoma of the Thoracic Spinal Epidural Space: A Case Report

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