Primitive neuroectodermal tumor of lumbar spine: case repor

He, Shisheng; Zhao, Jie; Han, Kaiwei; Hou, Tiesheng; Hussain, Nazakat; Zhang, Shun-Ming

doi:10.1097/00029330-200705010-00021

Cited by 7 publications

(36 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of these cases present with history of progressive increase in back pain and neurological deficit. Radiography of vertebral PNET typically shows destructive lesion of the spine, sometimes associated with a soft tissue mass 3. Majority of the lesions are purely lytic, and most arise in posterior elements, extending to the vertebral bodies.…”

Section: Discussionmentioning

confidence: 99%

“…The tumor arose from the L5 vertebra and caused compression of the thecal sac and cauda equina secondarily. These tumors are difficult to resect because of the nerve root involvement and carry an extremely poor prognosis with increase chances of recurrence and metastasis leading to dismal survival rates 3–8…”

Section: Discussionmentioning

confidence: 99%

“…It mainly exists in the central nervous system, chest wall, lower extremities, trunk, kidney and orbit but rarely in the spine. 3–8 Peripheral PNET (pPNET) of spine refers to all those tumors that arise from the surrounding soft tissues, vertebra or spinal nerve roots. To best of our knowledge, only 13 cases of PNET involving cauda equina have been reported in English language literature 356.…”

Section: Introductionmentioning

confidence: 99%

“…3–8 Peripheral PNET (pPNET) of spine refers to all those tumors that arise from the surrounding soft tissues, vertebra or spinal nerve roots. To best of our knowledge, only 13 cases of PNET involving cauda equina have been reported in English language literature 356. This article discusses about the diagnostic and therapeutic complexities of PNET of L5 vertebra in a young patient who presented with cauda equina lesion symptoms.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Peripheral primitive neuroectodermal tumor causing cauda equina syndrome with destruction of L5 vertebra

Dhatt

Dhillon

Trıpathy

et al. 2010

IJOO

View full text Add to dashboard Cite

A 24-year-old male patient presented with cauda equina lesion symptoms. His clinicoradiological examination including X-rays, CT scan and MRI revealed destruction of L5 vertebral body, pedicle and a mass extending to lateral recess and left intervertebral foramina causing pressure over the thecal sac. A CT guided FNAC was inconclusive. Open biopsy and hemilaminectomy of L5 vertebra was performed. Histopathology and immunocytochemical analysis revealed it to be primitive neuroectodermal tumor. Patient was given chemotherapy and radiation therapy. His lower limb power improved by grade I post operatively and at 2 years follow-up bowel/bladder recovery was noticed. Patient died after 2.5 years of surgery because of pulmonary metastasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Peripheral primitive neuroectodermal tumor causing cauda equina syndrome with destruction of L5 vertebra

Dhatt

Dhillon

Trıpathy

et al. 2010

IJOO

View full text Add to dashboard Cite

show abstract

“…Primitive neuroectodermal tumors are highly malignant and mainly exist in the central nervous system, chest wall, lower extremities, trunk, kidney and orbit but rarely spinal 1 . Cases of PNET have been increasingly reported in recent years but there is scarcity of reports of PNET originating primarily from the spinal cord.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2011

IJPSR

View full text Add to dashboard Cite

Primary spinal cord presentation of Primitive neuroectodermal tumors (PNET) is a rare occurrence and carries poor prognosis. A 13-year-old boy presented with pain in neck region, bilateral upper and lower limb weakness and bladder and bowel dysfunction. Neurological examination revealed the marked paresis with hyporeflexia of both the upper and lower extremities. Preoperative MRI of spine revealed an intradural mass at the C2-C5 level. A laminectomy of C2-C5 vertebra level and near total removal of the tumor was performed. Pathological findings were consistent with PNET. Chemotherapy along with radiotherapy was started and good response was observed. The clinical, histopathologic, and radiologic findings of the patient are presented. FIG. 1: INTRADURAL MASS AT THE C2-C5 LEVEL

show abstract

Primary central nervous system primitive neuroectodermal tumors (CNS-PNETs) of the spinal cord in children: four cases from the German HIT database with a critical review of the literature

et al. 2010

View full text Add to dashboard Cite

Approximately 30-50% of patients with intracranial primitive neuroectodermal tumors (PNETs) of the central nervous system (CNS) develop spinal metastases. In contrast, primary spinal CNS-PNETs are extremely uncommon. The database and study records of the German/Austrian brain tumor trials HIT 91, HIT SKK 92, and HIT 2000 were retrospectively reviewed to describe clinical features, treatment modalities, and outcome of children with primary CNS-PNETs of the spinal cord who were registered as observational patients. Out of 1,248 patients with medulloblastomas or CNS-PNETs registered in the HIT database four patients (female, n = 3) with primary CNS-PNETs of the spinal cord were identified. Age at diagnosis was 10, 16, 23, and 174 months. Location of primary tumors was medulla oblongata-T3, C2-T1, T10-L2, T7-T10. Two patients had metastatic disease at diagnosis. Complete and incomplete resection was performed in one patient each, whereas two patients underwent a biopsy only. Two patients received chemotherapy only, in accordance with the HIT 91 trial (sandwich chemotherapy arm). They developed disease progression and died six months after diagnosis. One patient was given chemotherapy in accordance with the HIT 2000 trial followed by craniospinal radiotherapy and four courses of maintenance chemotherapy. The patient is in complete remission almost four years after diagnosis. The fourth patient developed disease progression while receiving induction chemotherapy. Hence, chemotherapy was switched to a modified Head Start protocol. After three cycles he underwent double autologous stem cell transplantation and craniospinal irradiation. Forty months after diagnosis the patient is alive and well, but surveillance MRIs still show nodular enhancing lesions in the area of the primary tumor and intracranial meningeal enhancement. Primary CNS-PNETs of the spinal cord probably require multimodal treatment including radiotherapy to achieve sustained tumor control.

show abstract

Primitive neuroectodermal tumor of lumbar spine: case repor

Cited by 7 publications

References 13 publications

Peripheral primitive neuroectodermal tumor causing cauda equina syndrome with destruction of L5 vertebra

Peripheral primitive neuroectodermal tumor causing cauda equina syndrome with destruction of L5 vertebra

Untitled

Primary central nervous system primitive neuroectodermal tumors (CNS-PNETs) of the spinal cord in children: four cases from the German HIT database with a critical review of the literature

Contact Info

Product

Resources

About