Primitive neuroectodermal tumors/medulloblastoma

M, Weil

doi:10.1007/s11910-002-0078-2

Cited by 4 publications

(1 citation statement)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among these tumors, the highly metastatic medulloblastomas represent approximately 25% of all pediatric intracranial neoplasms [Saran, 2002]. These neoplasms arise from the cerebellum and mainly affect children between ages 5 and 15 [Weil, 2002]. Medulloblastomas are currently treated by surgical intervention, generally combined with aggressive chemotherapy [Kaaijk et al, 2003; Mazzola and Pollack, 2003].…”

mentioning

confidence: 99%

Medulloblastoma cell invasion is inhibited by green tea (−)epigallocatechin‐3‐gallate

Pilorget

Berthet

Luis

et al. 2003

J of Cellular Biochemistry

View full text Add to dashboard Cite

Epigallocatechin-3-gallate (EGCG), the major green tea polyphenol, can reach the brain following oral intake and could thus act as an anti-tumoral agent targeting several key steps of brain cancer cells invasive activity. Because integrin-mediated extracellular matrix recognition is crucial during the cell adhesion processes involved in carcinogenesis, we have investigated the effects of EGCG on different cellular integrins of the pediatric brain tumor-derived medulloblastoma cell line DAOY. Using flow cytometry, we report the levels of expression of several cell surface integrins in DAOY. These include high expression of alpha2, alpha3, and beta1 integrins, as well as alphav and beta3 integrins. Moreover, we provide evidence that EGCG can antagonize DAOY cell migration specifically on collagen by increasing cell adhesive ability through specific gene and protein upregulation of the beta1 integrin subunit. Our results suggest that this naturally occurring green tea polyphenol may thus be used as a nutraceutical therapeutic agent in targeting the invasive character of medulloblastomas.

show abstract

mentioning

confidence: 99%