2024
DOI: 10.1038/s41559-024-02361-4
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Primitive purine biosynthesis connects ancient geochemistry to modern metabolism

Joshua E. Goldford,
Harrison B. Smith,
Liam M. Longo
et al.

Abstract: A major unresolved question in the origin of life is whether there exists a continuous path from geochemical precursors to the majority of molecules in the biosphere, due in part to the autocatalytic nature of metabolic networks in modern-day organisms and high rates of extinction throughout Earth's history. Here we simulated the emergence of ancient metabolic networks to identify a feasible path from simple geochemical precursors (e.g., phosphate, sulfide, ammonia, simple carboxylic acids, and metals) to cont… Show more

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