Primordial Odontogenic Tumor: Report of a New Case and Literature Review

Bomfim, Bianca Bravim; Prado, Roberto; Sampaio, Renato Kobler; Conde, Danielle Castex; Andrade, Bruno Augusto Benevenuto de; Agostini, Michelle; Romañach, Mário José

doi:10.1007/s12105-018-0913-7

Cited by 27 publications

(18 citation statements)

References 12 publications

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“…Moreover, the polarization of mesenchymal cells suggests inductive activity and a differentiation to odontoblasts. Although the condensation of the mesenchymal cells in POT is interpreted as an induction phenomenon, the mesenchymal cells are not polarized unlike what was observed in the current case [9].…”

Section: Discussioncontrasting

confidence: 51%

Dental Germ Tumor: An Unusual, Cystic, Mixed Epithelial–Mesenchymal Odontogenic Tumor

Passador-Santos

Martelli

Gomes

et al. 2020

Head and Neck Pathol

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Although odontogenic lesions have been extensively described and studied, anomalous, challenging cases occasionally come to the attention of the pathologist. Here, we report the clinical and microscopic characteristics of an unusual cystic lesion of odontogenic origin. A 16-year-old male presented with swelling and pain to palpation of the right mandible as well as numbness of the right lower lip. Radiographically, the corresponding lesion was well-defined and radiolucent with internal radiopaque foci. It extended from the right first premolar posteriorly, approaching the angle of the mandible, and involved the mandibular first molar which was impacted and displaced. The second and third right mandibular molars were also impacted and displaced. The patient was treated by excisional biopsy under general anesthesia. The histopathologic examination revealed the presence of multicystic areas lined by a thin, non-keratinizing squamous epithelium that resembled the epithelial lining of a dentigerous cyst. In continuity with the cystic lining, areas of myxoid tissue reminiscent of dental papilla were observed. The myxoid tissue formed structures that were surfaced by an epithelium comprising a basal layer of ameloblast-like cells with reverse polarity of the nuclei. Above the basilar cells, additional layers of epithelial cells composed a structure resembling the enamel organ. Subjacent to the basilar ameloblast-like cells, a condensation of mesenchymal cells with polarized nuclei opposite to the ameloblast-like cells was present. These mesenchymal cells resembled odontoblasts. In addition, numerous mineralized structures amongst the odontogenic epithelial tissue were present. To date, the patient remains well and without evidence of recurrence after 36 months of follow-up.

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Section: Discussioncontrasting

confidence: 51%

Dental Germ Tumor: An Unusual, Cystic, Mixed Epithelial–Mesenchymal Odontogenic Tumor

Passador-Santos

Martelli

Gomes

et al. 2020

Head and Neck Pathol

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“…Clinically evident for 3 monthsRL, UL, well-defined, 35 × 30 mmEnucleation and tooth extraction6 months, NEDMosqueda-Taylor et al (2014) [2]719/MMandibleAsymptomatic, buccal and lingual swellingRL, UL, well-defined, 25 × 19 mmExcision and tooth extraction7 months, NEDSlater LJ et al (2016) [3]88/FMaxillaAsymptomatic, buccal swellingRL, UL, well-defined, 16 × 15 mmEnucleation16 months, NEDAndo et al (2017) [8]95/MMandibleAsymptomatic, buccal swellingRL, UL, well-defined, 80 × 80 mmExcision and tooth extraction7 months, NEDMikami et al (2017) [9]1017/MMandibleAsymptomatic, swellingRL, multilocular, well-defined, 30 × 20 mmEnucleation and tooth extraction6 months, NEDBajpai and Pardhe (2018) [10]1115/FMandibleSlight fullness of the right mandibular vestibuleRL, multilocular, well-defined, 35 × 20 mmExcision and tooth extraction3 months, NEDAsma Almazyad et al (2018) [11]1218/MMandibleAsymptomatic, incidentallynoted intra-osseous lesionRL, UL, well-defined, 12 × 7 mmCurettage and tooth extraction20 months, NEDAsma Almazyad et al (2018) [11]132/MMandibleAsymptomatic, swellingRL, multilocular, well-defined, 30 × 40 mmExcision and tooth extraction2 years, NEDHatem Amer et al (2018) [5]144/MMandibleAsymptomatic, buccal and lingual bony expansion. Clinically evident for 8 monthsRL, UL, well-defined, 30 × 20 mmEnucleation and tooth extractionFollow-up lostBomfim B B et al (2018) [6]1513/FMandibleAsymptomatic, volume augmentation. Clinically evident for 3 monthsRL, UL, well-definedEnucleation and tooth extraction13 years, NEDTeixeira L N et al (2019) [7]1610/MMandibleAsymptomaticUL, well-defined, 5 × 5 mmEnucleationone year, NEDPresent case…”

Section: Discussionmentioning

confidence: 99%

Primordial odontogenic tumor: a case report and literature review

et al. 2019

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Background A primordial odontogenic tumor (POT) is a rare, benign, mixed epithelial and mesenchymal odontogenic tumor that has been included as a new entity in the latest World Health Organization (WHO) classification (2017). POT consists of dental papilla-like myxoid connective tissue covered with a delicate membrane of ameloblastic epithelium. Only 15 cases have been documented worldwide, and here, we report the sixteenth case and the first one of South Korea. Case presentation An asymptomatic lesion was discovered as an incidental radiographic finding in a 10-year-old boy. The patient had no complaints about the lesion. Cone-beam computerized tomograms revealed a round cavity with a defined cortical border measuring approximately 5 × 5 × 5 mm in size. The lesion was a POT. The patient was treated with enucleation. The tumor showed no recurrence for one year. Conclusion This is the first report of POT in South Korea using the novel diagnosis of POT after it was recognized and defined in the latest WHO classification. This novel diagnosis will be useful for pathologists and clinicians in diagnosing and differentiating this new and rare disease from other odontogenic tumors.

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“…Some issues about POT remain unclear and require future reports. The description of the odontogenic epithelium covering the ectomesenchyme was often contradictory, while it remains debatable whether peripheral ameloblastic islands or hard dental tissue deposition can occasionally occur within the tumor [3,4].…”

Section: Discussionmentioning

confidence: 99%