Primordial odontogenic tumour: A systematic review of the common but also unusual features of this novel entity

Azzi, Lorenzo; Tettamanti, L; Francesco, Andrea Di; Cerati, Michele; Tagliabue, Angelo; Farronato, Davide; Maurino, Vittorio

doi:10.1016/j.jormas.2020.02.008

Cited by 6 publications

(2 citation statements)

References 36 publications

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“…Although a systematic review reported that POT does not show dental hard tissue production (Bologna-Molina et al, 2020), but recently reported case of POT present abundant enameloid and focal dentinoid deposition (Almazyad et al, 2022). These contradictions are in line with the latest systematic review about POT that reported both peripheral ameloblastic epithelial islands and deposition of hard dental tissue can occasionally happen within the tumor and have been remained arguable (Azzi et al, 2020).…”

Section: Discussionmentioning

confidence: 90%

Primordial Odontogenic Tumor; Archival Review of 19380 Cases in a 55-Year Retrospective Study

Ranjbar,

Moradzadeh Khiavi,

Ghazi

et al. 2023

Asian Pac J Cancer Prev

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Background and Objective: Primordial odontogenic tumor is a rare odontogenic tumor reported for the first time in 2014. It was included in the latest edition of World Health Organization classification of Head and Neck Tumors as a new benign mixed epithelial-mesenchymal neoplasm. To date, 26 cases has been reported in literature. The aim of this study was to determine the possible presence of primordial odontogenic tumor in the previously diagnosed cases with myxoid stroma. Materials and Methods: This study was a retrospective descriptive study that was concluded in Oral

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Section: Discussionmentioning

confidence: 90%

Primordial Odontogenic Tumor; Archival Review of 19380 Cases in a 55-Year Retrospective Study

Ranjbar,

Moradzadeh Khiavi,

Ghazi

et al. 2023

Asian Pac J Cancer Prev

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“…La expresión de Ki-67 fue baja y el componente epitelial fuertemente positivo para las inmunoexpresiones de AE1/3 y de CKs 5 y 14. Azzi et al (64) realizaron una revisión sistemática de la literatura para actualizar los datos sobre TOs primordiales. En este trabajo se identificaron 18 casos de TOs primordiales.…”

Section: Tumor Odontogénico Primordialunclassified

Bases moleculares de los tumores odontogénicos benignos: revisión de la literatura en el contexto de la última clasificación de la Organización Mundial de la Salud

2022

Odonto

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Odontogenic tumors (OTs) are a heterogeneous group of lesions that range from hamartomas to benign or malignant neoplasms. The present study aimed to review the literature regarding the molecular and genetic aspects from some benign OTs. Based on the review of the included studies, it is supported that genetic background may play an important role in the etiology and pathogenesis of OTs.However, the body of evidence on the subject still does not allow to conclude the definitive mechanisms involved in the development and progression of OTs. It is suggested the development of further molecular and genetic studies evaluating significant samples of OTs to establish its etiopathogenesis, facilitate its diagnostic process and enrich the therapeutic approaches.

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New diagnostic molecular markers and biomarkers in odontogenic tumors

et al. 2021

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Odontogenic tumors comprised of complex heterogeneous lesions that diverse from harmatomas to malignant tumors with different behavior and histology. The etiology of odontogenic tumors is not exactly determined and pathologists deal with challenges in diagnosis of odontogenic tumors because they are rare and obtained experiences are difficult to evaluate. In this study, we describe immunohistochemical and molecular markers in diagnosis of odontogenic tumors besides advanced diagnostic technique. Immunohistochemical features of odontogenic tumors beside the clinical features and radiological finding can help us to determine the correct diagnosis. Although these markers are neither specific nor sensitive enough, but analysis of gene expression provides definitive confirmation of diagnosis. In addition, “-omics” technology detected specific molecular alternation associated with etiology such as genomics, epigenomics, transcriptomics, proteomics and metabolomics. The post transcriptional events such as DNA methylation and chromatin remodeling by histone modification affect the changes in epigenome. Furthermore, non-coding RNAs like micro-RNAs, long noncoding RNA (lncRNA) and small non-coding RNA (snoRNA) play regulatory role and impact odontogenesis. Molecular marker propose their potential role in etiopathogenesis of odontogenic tumors and suitable candidate in diagnostic, prognostic and therapeutic approaches in addition to patient management. For future evaluations, organoid represents in vitro tumor model-study for tumor behavior, metastasis and invasion, drug screening, immunotherapy, clinical trial, hallmarks association with prognosis and evolution of personalized anti-cancer therapy. Moreover, organoid biobank help us to check genetic profile. We think more investigation and studies are needed to gain these knowledges that can shift therapeutic approaches to target therapy.

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Primordial odontogenic tumour: A systematic review of the common but also unusual features of this novel entity

Cited by 6 publications

References 36 publications

Primordial Odontogenic Tumor; Archival Review of 19380 Cases in a 55-Year Retrospective Study

Primordial Odontogenic Tumor; Archival Review of 19380 Cases in a 55-Year Retrospective Study

Bases moleculares de los tumores odontogénicos benignos: revisión de la literatura en el contexto de la última clasificación de la Organización Mundial de la Salud

New diagnostic molecular markers and biomarkers in odontogenic tumors

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