Principal component analysis exploring the association between antibiotic resistance and heavy metal tolerance of plasmid-bearing sewage wastewater bacteria of clinical relevance

Mandal, Manisha; Das, Saumendra Nath; Mandal, Shyamapada

doi:10.1099/acmi.0.000095

Cited by 13 publications

(11 citation statements)

References 56 publications

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“…Zhang et al., ( 2013 ) carried on PCA and cluster analysis in explaining antibiotic resistance indicators in E. coli isolated from aquaculture, indicating that MAR index defined detailed the antibiotic resistance profile. Mandal et al., ( 2020 ) performed PCA for assessing the resistance profiles and association of heavy metal tolerance and antibiotic resistance of clinically relevant bacteria, grouped into three factors with high total variance.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic resistance pattern of the allochthonous bacteria isolated from commercially available spices

György

Laslo

Antal

et al. 2021

Food Science & Nutrition

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Spices are various plant parts that contain flavor and aroma compounds that in small amounts enhance the enjoyment value of foods.Nowadays, spices play a key role in modern food preparation as they contribute to salt reduction, reduce the utilization of artificial additives, impart natural color to foods, and act as natural antioxidants (Clemenson, 2019). Spices have been found to provide health benefits based on their bioactive ingredients. Diverse spices and herbs, namely anise, cinnamon, black cumin, curry, coriander, ginger, fenugreek, turmeric, garlic, mustard, pepper, and onion, are potentially involved in diabetes control (Sanlier & Gencerb, 2020).Spices are additives used in small quantities, owing to a high potential for microbial contamination as they are used in many food commodities. This possibility may be attributed to the existing various critical points (vulnerabilities) of microbial contamination during plant cultivation and product supply chain (Alegbeleye et al., 2018;Székács et al., 2018). Even though the spices have low water activity, they could be harbored by diverse pathogenic and spoilage microorganisms (Costa et al., 2020;Melo González et al., 2017). As dried herb products, they may be contaminated by different molds too.Due to the high tolerance to dehydration stress, Salmonella species can survive longer in dry products such as spices. The contamination can occur at several phases of the production including

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Section: Discussionmentioning

confidence: 99%

Antibiotic resistance pattern of the allochthonous bacteria isolated from commercially available spices

György

Laslo

Antal

et al. 2021

Food Science & Nutrition

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“…The authors have proposed, based on these historical resistance data, potential avenues for the spreading of antimicrobial resistance genes [51]. Mandal et al studied the correlation between the multiple antibiotic resistance (MAR) phenotype and heavy metal (Hg 2+ , Cd 2+ , Cr 2+ , and Cu 2+ ) resistance in E. coli and non-fermenting Gram-negative bacteria isolated from sewage wastewater, and found significant correlation between MAR indices and heavy metal tolerance [52].…”

Section: Discussionmentioning

confidence: 99%

Interplay between Phenotypic Resistance to Relevant Antibiotics in Gram-Negative Urinary Pathogens: A Data-Driven Analysis of 10 Years’ Worth of Antibiogram Data

Gajdács

Bátori

Burián

2021

Life

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The global emergence of antimicrobial resistance (AMR) has become a critical issue for clinicians, as it puts the decades of developments in the medical field in jeopardy, by severely limiting the useful therapeutic arsenal of drugs, both in nosocomial and community-acquired infections. In the present study, a secondary analysis of taxonomic and resistance data was performed, corresponding to urinary tract infections (UTIs) caused by Gram-negative bacteria, detected between 1 January 2008 to 31 December 2017 at the Albert Szent-Györgyi Health Center, University of Szeged. The following were identifiable from the data collected: year of isolation; outpatient (OP)/inpatient (IP) origin of the isolate; taxonomy; and susceptibility/resistance to selected indicator antibiotics. Principal component analysis (PCA) and a correlation matrix were used to determine the association between the presences of resistance against indicator antibiotics in each taxonomic group. Overall, data from n = 16,240 outpatient and n = 13,964 inpatient Gram-negative UTI isolates were included in the data analyses. In E. coli, strong positive correlations were seen between resistance to ciprofloxacin (CIP) and gentamicin (GEN) resistance (OP: r = 0.6342, p = 0.049; IP: r = 0.9602, p < 0.001), whereas strong negative correlations were shown for fosfomycin (FOS) and nitrofurantoin (NIT) resistance (OP: r= −0.7183, p = 0.019; IP: r= −0.7437; p = 0.014). For Klebsiella spp. isolates, CIP resistance showed strong positive correlation with resistance to third-generation cephalosporins (3GC) and GEN (r = 0.7976, p = 0.006 and r = 0.7428, p = 0.014, respectively) in OP isolates, and with resistance to trimethoprim-sulfamethoxazole (SXT) and FOS (r = 0.8144, p = 0.004 and r = 0.7758, p < 0.001, respectively) in IP isolates. For members of the Citrobacter-Enterobacter-Serratia group, the resistance among indicator antibiotics showed a strong positive correlation, with the exception of FOS resistance. In the Proteus-Providencia-Morganella group, the strongest association was noted between CIP and SXT resistance (OP: r = 0.9251, p < 0.001; IP: r = 0.8007; p = 0.005). In the case of OP Acinetobacter spp., CIP showed strong and significant positive correlations with most indicator antibiotics, whereas for IP isolates, strong negative correlations arose among imipenem (IMI) resistance and resistance to other drugs. For Pseudomonas spp., strong and positive correlations were noted among resistance to β-lactam antibiotics and aminoglycosides, with the exception of ceftazidime (CEFT), showing strong, but negative correlations. Though molecular tests and sequencing-based platforms are now considered as the gold-standard for AMR surveillance, standardized collection of phenotypic resistance data and the introduction of Big Data analytic methods may be a viable alternative for molecular surveillance, especially in low-resource settings.

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“…This variation in metal tolerance might be due to the presence of different tolerance mechanisms (Irawati et al 2017). B. safensis strain NBRC and L. chromiiresistens strain JG showed the highest heavy metal tolerance and were resistant to heavy metals in the order of Pb > Cr > Co > Ni; they were also resistant to higher concentrations than those recorded by (Mandal et al 2020). Among the investigated heavy metals, iron was the least toxic, whereas cadmium, copper, and zinc were highly toxic to all strains.…”

Section: Bacterial Tolerance To Heavy Metal Saltsmentioning

confidence: 94%

Evaluation of heavy metal content in water and removal of metals using native isolated bacterial strains

2021

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Abstract. Saleh LIF, Rashed RO, Muhammed SM. 2021. Evaluation of heavy metal content in water and removal of metals using native isolated bacterial strains. Biodiversitas 22: 3163-3174. Natural surface water sources are susceptible to chemical contamination, including heavy metals. The goals of this study were to isolate naturally occurring heavy metal-tolerant bacteria by evaluating their ability to remove heavy metals from Tanjaro River and assessing the river’s water quality. The potency of bacteria to remove heavy metals (Cd, Pb, Cu, Cr, Ni, Zn, Co, and Fe) from the medium was conducted by inductively coupled plasma-optical emission spectrometry. Results of physicochemical parameters of the water samples were as follows: temperature 11.9–31°C, pH 6.1–8.64, total dissolved solids 268–464 mg.l-1, total hardness 232–485 mg.l-1, and alkalinity 122–324.3 mg.l-1. The overall mean concentrations of the heavy metals were in the order of Zn >Cu> Pb> Ni> Co> Fe> Cr> Cd), with values of 0.086, 0.073, 0.71, 0.068, 0.051, 0.056, 0.031, and 0.024ppm, respectively Moreover, the concentrations were generally exceeded the water quality criteria of WHO in some observations. The isolates included both gram-negative (56.5%) and gram-positive (43.5%) bacteria. The isolates displayed different degrees of resistance to heavy metals with maximum tolerable concentrations (MTCs) ranging from (10-250) ppm. Bacillus safensis and Leucobacter chromiiresistens were respectively able to tolerate (80, 90 ppm) Cd, (250, 160 ppm) Pb, (210,100 ppm) Cr, (110, 90 ppm) Ni and (160, 170 ppm) Co, while, Proteus mirabilis could tolerate 90 ppm Cd. The isolates were able to remove 55.4%Pb, 53.1%Cr, 53.7%Ni, 47.7Fe, 61.4%Co, and 55.8% Cu from a medium supplemented with the mixture of these heavy metals. The finding of this study indicated that Tanjaro River was undergoing frequent changes in water quality. Native bacterial isolates possessed considerable tolerance to selected heavy metals, which provides promising candidates for use in bioremediation.

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Principal component analysis exploring the association between antibiotic resistance and heavy metal tolerance of plasmid-bearing sewage wastewater bacteria of clinical relevance

Cited by 13 publications

References 56 publications

Antibiotic resistance pattern of the allochthonous bacteria isolated from commercially available spices

Antibiotic resistance pattern of the allochthonous bacteria isolated from commercially available spices

Interplay between Phenotypic Resistance to Relevant Antibiotics in Gram-Negative Urinary Pathogens: A Data-Driven Analysis of 10 Years’ Worth of Antibiogram Data

Evaluation of heavy metal content in water and removal of metals using native isolated bacterial strains

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