Principles and Complications of Chemotherapy

Oxaliplatin disrupts nucleolar function through biophysical disintegration

“…This may explain why oxaliplatin is able to effectively target ribosome biogenesis in the clinic, whereas the potent transcription inhibitor actinomycin D is too toxic for widespread use. 47 Thus, targeting the biophysical properties of membrane-less organelles such as nucleoli may be a promising chemotherapeutic strategy, especially for translation-addicted cancers such as CRCs. 8 , 18 …”

Folate conjugated albumin as a targeted nanocarrier for the delivery of fisetin: in silico and in vitro biological studies

“…1 For several decades, chemotherapy has been a mainstay in the treatment of various cancers. 2 But still faces challenges including multidrug resistance, 3 non-selectivity between healthy and cancer tissue 4 and cytotoxic side effects such as hepatotoxicity, 5 cardiotoxicity, 6 neurotoxicity, 7 nephrotoxicity 8 etc. are remaining challenges for chemotherapeutic drugs.…”

Perceptions of Older Adults with Hematological Cancer on Diet and Exercise Behavior and Its Role in Navigating Daily Tasks

“…A recent systematic review and meta-analysis showed that low muscle mass was associated with poorer physical functioning domain and global health-related quality of life (HRQOL) scores, as well as a longitudinal association between changes in skeletal muscle and several HRQOL domains in adults with cancer [ 8 ]. Loss of muscle mass and strength in those with hematological cancer seem to be attributed to the interplay among the cytotoxic effects of chemotherapy [ 9 , 10 ], the treatment’s side-effects and the disease itself [ 11 , 12 , 13 ], resulting in reduced oral intake and low energy. The latter negatively impacts engagement in daily tasks and being physically active, which results in a vicious cycle of loss of muscle mass and strength [ 7 , 14 ], reduced physical function and poor HRQOL [ 15 ].…”