Principles and management of head and neck cancer

Lester, Shane; Yang, Woo-Young

doi:10.1016/j.mpsur.2012.09.002

Cited by 7 publications

(13 citation statements)

References 6 publications

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“…Advanced-stage carcinoma of the floor of the mouth is preferably treated with a multimodality approach: surgery and radiation therapy of the primary tumor site (5,6,11,13) (Fig 8). A surgical technique used in this context is the combined mandibulotomy and neck dissection operation (COMMANDO), which involves resection of the floor of the mouth and the portion of the mandible in continuity with the oral lesion, as well as radical neck dissection (14,15).…”

Section: Resection Of the Floor Of The Mouthmentioning

confidence: 99%

Postsurgical Imaging of the Oral Cavity and Oropharynx: What Radiologists Need to Know

García¹,

Passos²,

Ezzedine³

et al. 2015

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The oral cavity and oropharynx are common locations of neoplastic lesions; neoplasms at these sites are often treated with surgery. The goal of this surgical treatment is to achieve tumor control while preserving, whenever possible, the function of local structures. The procedure used depends largely on the location and extension of the tumor and the disease stage. Follow-up evaluation of patients is done with computed tomography (CT) and magnetic resonance (MR) imaging. The ability to interpret characteristic features at CT and MR imaging is particularly important because normal anatomic structures are altered in specific patterns according to the distinct surgical technique applied. Anatomic changes resulting from the most commonly performed procedures (eg, glossectomy, pelvectomy, and mandibulectomy) will be presented with CT and MR images, multiplanar reconstructions, and schematic illustrations. Understanding of postsurgical CT and MR imaging findings is important to avoid misinterpretation and confusion. Familiarity with the typical postsurgical imaging appearance of the oral cavity and oropharynx is crucial for differentiating normal postsurgical changes from persistent or recurrent disease and for diagnosis of associated second primary malignancies. Knowledge of postsurgical findings is essential for analysis of the oral cavity and oropharynx and allows early diagnosis of tumor recurrence or typical complications after surgical reconstruction.

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Section: Resection Of the Floor Of The Mouthmentioning

confidence: 99%

Postsurgical Imaging of the Oral Cavity and Oropharynx: What Radiologists Need to Know

García¹,

Passos²,

Ezzedine³

et al. 2015

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“…The production and articulation of speech, swallowing, and respiration are functions controlled by the oral cavity, pharynx, and larynx. In addition, these structures also protect the airways [ 21 , 22 ]. Damage to one of these structures may affect the functioning of the others.…”

Section: Anatomophysiology Of the Head And Neckmentioning

confidence: 99%

Insights into Nanomedicine for Head and Neck Cancer Diagnosis and Treatment

2022

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Head and neck cancers rank sixth among the most common cancers today, and the survival rate has remained virtually unchanged over the past 25 years, due to late diagnosis and ineffective treatments. They have two main risk factors, tobacco and alcohol, and human papillomavirus infection is a secondary risk factor. These cancers affect areas of the body that are fundamental for the five senses. Therefore, it is necessary to treat them effectively and non-invasively as early as possible, in order to do not compromise vital functions, which is not always possible with conventional treatments (chemotherapy or radiotherapy). In this sense, nanomedicine plays a key role in the treatment and diagnosis of head and neck cancers. Nanomedicine involves using nanocarriers to deliver drugs to sites of action and reducing the necessary doses and possible side effects. The main purpose of this review is to give an overview of the applications of nanocarrier systems to the diagnosis and treatment of head and neck cancer. Herein, several types of delivery strategies, radiation enhancement, inside-out hyperthermia, and theragnostic approaches are addressed.

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“…Oncological maxillofacial surgery is a branch of maxillofacial surgery which deals with the surgical approach to head and neck malignancies and the reconstruction of the lost tissues [64].…”

Section: E Clinical Case Studymentioning

confidence: 99%

Application of DMAIC Cycle and Modeling as Tools for Health Technology Assessment in a University Hospital

Ponsiglione

Ricciardi

Scala

et al. 2021

Journal of Healthcare Engineering

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Background. The Health Technology Assessment (HTA) is used to evaluate health services, manage healthcare processes more efficiently, and compare medical technologies. The aim of this paper is to carry out an HTA study that compares two pharmacological therapies and provides the clinicians with two models to predict the length of hospital stay (LOS) of patients undergoing oral cavity cancer surgery on the bone tissue. Methods. The six Sigma method was used as a tool of HTA; it is a technique of quality management and process improvement that combines the use of statistics with a five-step procedure: “Define, Measure, Analyze, Improve, Control” referred to in the acronym DMAIC. Subsequently, multiple linear regression has been used to create two models. Two groups of patients were analyzed: 45 were treated with ceftriaxone while 48 were treated with the combination of cefazolin and clindamycin. Results. A reduction of the overall mean LOS of patients undergoing oral cavity cancer surgery on bone was observed of 40.9% in the group treated with ceftriaxone. Its reduction was observed in all the variables of the ceftriaxone group. The best results are obtained in younger patients (−54.1%) and in patients with low oral hygiene (−52.4%) treated. The regression results showed that the best LOS predictors for cefazolin/clindamycin are ASA score and flap while for ceftriaxone, in addition to these two, oral hygiene and lymphadenectomy are the best predictors. In addition, the adjusted R squared showed that the variables considered explain most of the variance of LOS. Conclusion. SS methodology, used as an HTA tool, allowed us to understand the performance of the antibiotics and provided variables that mostly influence postoperative LOS. The obtained models can improve the outcome of patients, reducing the postoperative LOS and the relative costs, consequently increasing patient safety, and improving the quality of care provided.

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Principles and management of head and neck cancer

Cited by 7 publications

References 6 publications

Postsurgical Imaging of the Oral Cavity and Oropharynx: What Radiologists Need to Know

Postsurgical Imaging of the Oral Cavity and Oropharynx: What Radiologists Need to Know

Insights into Nanomedicine for Head and Neck Cancer Diagnosis and Treatment

Application of DMAIC Cycle and Modeling as Tools for Health Technology Assessment in a University Hospital

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