Principles governing biomolecule interactions at foreign interfaces

Hoffman, Allan S.

doi:10.1002/jbm.820080309

Cited by 53 publications

(10 citation statements)

References 8 publications

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“…In the simplest view, the major adsorbed species are likely to be plasma proteins, and there is some evidence that their adsorption on hydrophobic surfaces is largely irreversible. 32 This would be consistent with the observation that all hydrophobic implants have similar minimal soft tissue responses. Hydrophilic surfaces, on the other hand, readily desorb proteins, a fact made much use of in the chromatographic separation of protein m i x t~r e s .~~,~~ From this simple argument, I suggest that there may exist a critical hydrophobic character which a surface must, possess for essentially irreversible plasma protein adsorption, and that all surfaces with at least this levcl of hydrophobicity are likely to elicit similar minimal soft tissue responses.…”

Section: An Alternative Approachsupporting

confidence: 88%

An approach to the soft tissue/synthetic material interface

Bagnall

1977

J. Biomed. Mater. Res.

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It is argued that chemical modification of soft tissue implants in the hope of obtaining an associated tissue response is unlikely to succeed as a method for studying the fundamentals of implant/tissue interactions. An alternative approach is proposed which places greater emphasis on the interfacial interactions (such as protein adsorption) which occur after implantation, in a manner paralleling current advances in knowledge of the blood/material interface. From simple arguments, it is proposed that the observed similarities in soft tissue response of hydrophobic materials may result from irreversible protein adsorption, and that if unusual tissue responses are possible they are likely to be found only with hydrophilic implants. The possiblity of a critical hydrophilic/hydrophobic character which an implant must possess for essentially irreversible protein adsorption is also discussessed.

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Section: An Alternative Approachsupporting

confidence: 88%

An approach to the soft tissue/synthetic material interface

Bagnall

1977

J. Biomed. Mater. Res.

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“…Alternatively, the initial attraction may be due to van der Waals' forces or to hydrogen bonding and followed much later or not at all by interracial coagulation. Entropic factors would probably be involved in any case [36,37]. These two possibilities could probably be distinguished by examining the exchangeability of the adsorbed phase with molecules in solution--when one would predict a lack of equilibrium conditions if the first process were operating.…”

Section: Discussionmentioning

confidence: 98%

Ion displacement following the adsorption of anionic macromolecules on hydroxyapatite

Pearce

1981

Calcif Tissue Int

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Certain small anionic molecules displace phosphate ions from the hydroxyapatite crystal hydration layer on adsorption. This follows the interaction of negatively charged groups with calcium ions in the crystal surface. The present study examines ion-exchange processes occurring during the adsorption of anionic macromolecules and attempts to determine the role of coulombic forces in the process. Various natural and synthetic polyanionic substances were added to a buffered hydroxyapatite slurry and adsorption measured by solution depletion. Calcium and phosphate ion displacement or uptake by apatite was determined after accounting for polymer-bound ions. Carboxymethylcellulose and a polyacrylamide sample in which 54% of amide groups had been hydrolyzed to carboxyl were adsorbed in the lowest amounts, but both caused consistent rises in the bulk solution phosphate level. Crude bovine submaxillary mucin and a polyacrylamide sample in which 28% of amide groups had been hydrolyzed were adsorbed in greater amounts but caused little or no phosphate displacement. In no case was there a stoichiometric relation between carboxyl adsorbed and phosphate displaced. The polyacrylamide samples also displaced Ca ions into the bulk solution, whereas the other macromolecules caused a decrease in solution Ca concentration. These results provide some evidence for the operation of an ion-exchange mechanism in the adsorption of polyanions on hydroxyapatite but do not exclude the involvement of other mechanisms, especially in the case of salivary mucin.

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“…) indicates that there might be a change in the fibrinogen upon adsorption to the material surface. Since proteins adsorb to the surface immediately upon insertion, the adsorbed fibrinogen, and not the material's surface, will affect all subsequent biological moieties that pass the implanted device. Since it is well established that these surfaces will prevent clotting, there may be a change in the adsorbed fibrinogen that effects its interaction with other clotting factors such as platelets.…”

Section: Discussionmentioning

confidence: 99%

Nitric oxide releasing material adsorbs more fibrinogen

Lantvit

Barrett

Reynolds

2013

J Biomedical Materials Res

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One mechanism of the failure of blood-contacting devices is clotting. Nitric oxide (NO) releasing materials are seen as a viable solution to the mediation of surface clotting by preventing platelet activation; however, NO's involvement in preventing clot formation extends beyond controlling platelet function. In this study, we evaluate NO's effect on factor XII (fibrinogen) adsorption and activation, which causes the initiation of the intrinsic arm of the coagulation cascade. This is done by utilizing a model plasticized poly(vinyl) chloride (PVC), N-diazeniumdiolate system and looking at the adsorption of fibrinogen, an important clotting protein, to these surfaces. The materials have been prepared in such a way to eliminate changes in surface properties between the control (plasticized PVC) and composite (NO-releasing) materials. This allows us to isolate NO release and determine the effect on the adsorption of fibrinogen, to the material surface. Surprisingly, it was found that an NO releasing material with a surface flux of 17.4 ± 0.5 × 10(-10) mol NO cm(-2) min(-1) showed a significant increase in the amount of fibrinogen adsorbed to the material surface compared to one with a flux of 13.0 ± 1.6 × 10(-10) mol NO cm(-2) min(-1) and the control (2334 ± 496, 226 ± 99, and 103 ±31% fibrinogen adsorbed of control, respectively). This study suggests that NO's role in controlling clotting is extended beyond platelet activation.

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Principles governing biomolecule interactions at foreign interfaces

Cited by 53 publications

References 8 publications

An approach to the soft tissue/synthetic material interface

An approach to the soft tissue/synthetic material interface

Ion displacement following the adsorption of anionic macromolecules on hydroxyapatite

Nitric oxide releasing material adsorbs more fibrinogen

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