Principles of Advanced Manufacturing Technologies for Biomedical Devices

Samuel, G.L.; Kong, Lingxue; Arcot, Yugandhar; Pandit, Pavan

doi:10.1007/978-981-16-3645-5_16

Cited by 2 publications

(3 citation statements)

References 66 publications

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“…PCL in the form of filament for 3D printing approaches like fused deposition modeling (FDM) has some great properties such as inject ability of fused, suitable solidification rate, and self‐setting, whereas, in the case of 3D printing, PCL in the form of ink does not have the good bridging capacity to form a suspended layer 17 . In order to solve this problem, the use of a suitable temporary porogen has been reported many times in previous studies 18 . Shim et al 19 have reported that NaCl can be a good porogen in the PCL matrix due to its good solubility in water and nontoxic effect on living cells.…”

Section: Introductionmentioning

confidence: 99%

“…17 In order to solve this problem, the use of a suitable temporary porogen has been reported many times in previous studies. 18 Shim et al 19 have reported that NaCl can be a good porogen in the PCL matrix due to its good solubility in water and nontoxic effect on living cells. In the other study, Guarino et al 20 showed that the yield stress of PCL scaffolds by the addition of NaCl was reduced from 1 to 0.05 MPa for 50% and 91% vol.…”

Section: Introductionmentioning

confidence: 99%

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In vitro evaluation of polycaprolactone‐based structure for guiding segmental bone defect

Khodabakhshi,

Soleimanimehr,

Etemadi Haghighi

et al. 2023

Polymer Engineering & Sci

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Segmental bone tissue engineering is a highly effective approach for the repair of large bone defects. In this article, 3D printing was used to fabricate the polycaprolactone (PCL)/NaCl‐based cylindrical structures. The effects of the structure's thickness (L) and NaCl concentration on the mechanical properties, degradability, swelling behavior, porosity, and cytotoxicity of the samples were investigated. Response surface methodology was employed to study the mechanical behavior using the central composite design (CCD). Results showed that increasing the NaCl concentration up to 10% wt significantly improved the degradability, swelling, and hydrophilicity of the structures. It was also indicated that the maximum stiffness of the guide structures under vertical loading was almost five times larger than the horizontal loading direction, but the samples showed greater compressive strength and elongation under horizontal compressive loading. Results indicated that the mechanical properties of the structures were more dependent on the structure thickness so the thicker structures with an 800 μm thickness had better mechanical properties in both vertical and horizontal loading. Cytotoxicity assay also approved the nontoxic effect of the PCL structures on the MC3T3 osteoblast cell line. Based on the results, the PCL‐based structures were a suitable candidate to act as a guide for segmental bone tissue engineering.Highlights A 3D‐printed conduit was manufactured to guide bone reconstruction Response surface methodology (RSM) using central composite design (CCD) was employed NaCl concentration and the diameter of strands were the main parameters This 3D‐printed guiding approach is useful for segmental bone tissue engineering

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of polycaprolactone‐based structure for guiding segmental bone defect

Khodabakhshi,

Soleimanimehr,

Etemadi Haghighi

et al. 2023

Polymer Engineering & Sci

View full text Add to dashboard Cite

show abstract

“…PCL as ink for 3D printing approaches (fused deposition modeling (FDM)) has some great properties such as inject ability of fused, suitable solidi cation rate, and self-setting, but in the case of 3D printing of porous strictures with a suspend layer, the PCL ink does not have good bridging capacity to form a suspend layer . In order to solve this problem, the use of a suitable temporary space holder has been reported many times in previous studies (Samuel, Kong et al 2022). Shim et al (Shim, Sa et al 2016) have reported that NaCl can be a good space holder in the PCL matrix due to its good solubility in water and nontoxic effect on the living cells.…”

Section: Introductionmentioning

confidence: 99%

In-vitro evaluation of PCL-based film for guiding segmental bone defect

Khodabakhshi

Soleimanimehr

Haghighi

et al. 2022

Preprint

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Segmental bone tissue engineering is a highly effective approach for the repair of large bone defects. In this paper, a PCL-based guide film was developed for controlling segmental bone tissue engineering. 3D bioprinting was used to fabricate the PCL/NaCl-based cylindrical films. The effects of the film's thickness and NaCl concentration on the mechanical properties, degradability, swelling behavior, porosity, and cytotoxicity of the samples were investigated. Response surface methodology was employed to study the mechanical behavior using the central composite design (CCD) results showed that increasing the NaCl concentration up to 10% wt. significantly improved the degradability, swelling, and hydrophilicity of the films. It was also indicated that the maximum stiffness of the guide films under vertical loading was almost 5 times more than the maximum stiffness in the horizontal loading direction, but the samples showed greater compressive strength and elongation under horizontal compressive loading. All the evidence indicated that the mechanical properties of the films were more dependent on the film thickness so the thicker films with an 800µm thickness had better mechanical properties in both vertical and horizontal loading. Cytotoxicity assay also approved the non-toxic effect of the PCL films on the MC3T3 osteoblast cell line. Based on the results, the PCL-based films were a suitable candidate to act as a guide for segmental bone tissue engineering.

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Principles of Advanced Manufacturing Technologies for Biomedical Devices

Cited by 2 publications

References 66 publications

In vitro evaluation of polycaprolactone‐based structure for guiding segmental bone defect

In vitro evaluation of polycaprolactone‐based structure for guiding segmental bone defect

In-vitro evaluation of PCL-based film for guiding segmental bone defect

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