The economic security category of the region is complex, multifaceted and has many features. Therefore, the use of a multifactorial approach to assessing economic security is justified. Assessment of the economic security of a region is possible provided that formal approaches are used, using specific indicators. The practical implementation of the analytical and regulatory components of the process of ensuring the economic security of the region requires an economic assessment on the basis of and in comparison with the thresholds. In order to control the level of economic security of the region in order to develop preventive measures for expected threats, it is necessary to carry out a continuous study of the regional economic situation on the chosen system of indicators. The quantitative expression of indicators determines the thresholds for the functioning of the economic system of the region.