Principles of bone and tissue banking in Saudi Arabia: 10-year experience report

Ilyas, Imran; Al-Rabiah, Anwar M; Alhussainan, Thamer S; Alrumaih, Husam A.; Fallatah, Abdulelah B; Alsakran, Shuruq A; Al-Mohrej, Omar A.

doi:10.1007/s10561-020-09868-7

Cited by 5 publications

(2 citation statements)

References 39 publications

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“…The bone bank can store allografts from living or cadaveric donors and safely supply them for recipients, and must prevent the transmission of infectious diseases and malignancies through routine culture swabs and serological screening [ 2 , 4 , 5 , 7 ]. However, there are no uniform guidelines for the management of bone banks, and most bone bank protocols for quality control follow the guidelines recommended by the American Association of Tissue Banks and also meet the national law standards [ 1 , 3 , 6 , 14 , 15 , 16 ]. The discard rates reported in the literature vary from 5% to 46% [ 8 , 14 , 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Role of Intraoperative Positive Culture of Allograft Bone in Subsequent Postoperative Infections among Donors and Recipients in Bone Bank Processing

Tsai,

Chen,

Huang

et al. 2023

Diagnostics

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Background: Allografts have been frequently used in orthopedic procedures. The purposes of this study were to evaluate the discard rates and bacterial contamination of a bone bank, and to assess the clinical outcomes of recipients with bacterial culture-positive donor allografts. Methods: We retrospectively reviewed 1764 allografts which were harvested from living donors and stored in a bone bank from 2018 to 2022. The donors whose allografts displayed bacterial contamination at retrieval of the primary hip or knee arthroplasty were followed for microbiology and subsequent prosthetic joint infection analysis. The infected pathogens, antibiotic treatment and subsequent infection were reviewed for the intraoperative positive culture group. Results: The discard rate was 17%, and the bacterial contamination rate of bone retrieval was 2.15%. Thirty-eight allografts at retrieval displayed confirmed bacterial growth, and 37 patients did not reveal infective signs at 6 months follow-up. A total of 1464 allografts were stored and implanted, among which 28 allografts (1.91%) were confirmed to be positive for bacterial growth and 13 cases (0.89%) were confirmed as surgical site infections. Conclusions: Our results validate the suggestion that our bone bank system performs good quality monitoring to eliminate the risk of dissemination of viral and bacterial diseases and to decrease surgical site infection after allograft implantation. By ensuring aseptic conditions and contamination-reducing strategies during harvesting and thawing, the allografts can be safely stored and implanted while limiting bacterial contamination. Our findings confirm that the intraoperative positive cultures of allografts did not contribute to subsequent postoperative surgical site infection in donors and recipients.

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Section: Discussionmentioning

confidence: 99%

Exploring the Role of Intraoperative Positive Culture of Allograft Bone in Subsequent Postoperative Infections among Donors and Recipients in Bone Bank Processing

Tsai,

Chen,

Huang

et al. 2023

Diagnostics

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“…These were provided by our bone bank, which is located on the premises of the hospital. All the grafts were fresh frozen and gamma-irradiated (25 kGy) [21].…”

Section: Allograft Usedmentioning

confidence: 99%

High Incidence of Irradiated Cortical Strut Allograft Resorption Following Revision of Femoral Stems

Ilyas

Al-Mohrej

2021

The Journal of Arthroplasty

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Background: Despite the widespread use of revision total hip arthroplasties using cementless stems and cortical strut allografts, graft resorption has not been explicitly studied. Methods: Between 2010 and 2018, 40 femoral strut grafts were used in the revision of femoral stems of 36 patients (18 males and 18 females; average age, 51.9 ± 12.9 years). The mean follow-up was 78.9 ± 37.3 months. Failure was defined as revision surgery for any reason and subsidence of greater than 5 mm. Results: The survival rate of the stem without the need for revision at 5 years was 95% (mean graft survival time, 10.8 [95% CI, 9.414-12.234] years). Overall survival with graft resorption as the endpoint was 90% at 5 years (mean graft survival time, 8.8 [95% CI, 7.5-10.2] years). Survival with graft nonunion as the endpoint was 90% at 3 years (mean survival time, 11.7 [95% CI, 10.5-12.8] years). Conclusion:The resorption rate increases proportionally to the follow-up duration and can be very severe in a high percentage of cases. Long-term multicenter studies are required to assess the effect of resorption on prosthesis longevity.

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The contamination of allografts in multi-organ donors: a bone bank experience

et al. 2021

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Principles of bone and tissue banking in Saudi Arabia: 10-year experience report

Cited by 5 publications

References 39 publications

Exploring the Role of Intraoperative Positive Culture of Allograft Bone in Subsequent Postoperative Infections among Donors and Recipients in Bone Bank Processing

Exploring the Role of Intraoperative Positive Culture of Allograft Bone in Subsequent Postoperative Infections among Donors and Recipients in Bone Bank Processing

High Incidence of Irradiated Cortical Strut Allograft Resorption Following Revision of Femoral Stems

The contamination of allografts in multi-organ donors: a bone bank experience

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