Principles of chemotherapy

Lundqvist, Elisabeth Åvall

doi:10.1016/s0020-7292(12)60028-9

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Chemotherapeutic drugs, such as the anti-metabolite 5-Fluorouracil (5-FU) are broadly effective at treating solid tumours and haematological malignancies 1 . However, these cytotoxic agents indiscriminately target both malignant and normal dividing cells of the gastrointestinal tract; often resulting in the serious condition known as mucositis 2 . Mucositis is characterised by ulceration and inflammation of the mucosa with clinical symptoms including severe pain, rectal bleeding, bloating, nausea, vomiting and diarrhoea 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Emu Oil Combined with Lyprinol™ Reduces Small Intestinal Damage in a Rat Model of Chemotherapy-Induced Mucositis

Mashtoub

Lampton

Eden

et al. 2016

Nutrition and Cancer

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Chemotherapy-induced mucositis is characterized by inflammation and ulcerating lesions lining the alimentary tract. Emu Oil and Lyprinol™ have independently demonstrated their therapeutic potential in intestinal inflammatory disorders, including mucositis. We investigated Emu Oil and Lyprinol™ in combination for their further potential to alleviate chemotherapy-induced mucositis in rats. Rats were gavaged with (1 ml) water, Olive Oil, Emu Oil + Olive Oil, Lyprinol™ + Olive Oil or Emu Oil + Lyprinol™ from Days 0 to 7, injected with saline (control) or 5-Fluorouracil (5-FU) on Day 5 and euthanized on Day 8. Myeloperoxidase (MPO) activity (indicative of acute inflammation), histological severity scores, and intestinal architecture were quantified. Myeloperoxidase activity was significantly increased in the jejunum and ileum following 5-FU, compared to saline controls. Both Olive Oil and Emu Oil + Lyprinol™ significantly reduced jejunal MPO levels (1.8-fold and 1.7-fold, respectively), whereas only Emu Oil + Lyprinol™ significantly decreased ileal MPO levels, relative to 5-FU controls. All oil treatments decreased histological severity scores in the jejunum and ileum, and normalized crypt depth in the mid small intestine, relative to 5-FU controls. Emu Oil combined with Lyprinol™ partially reduced acute small intestinal inflammation. Isolating bioactive constituents of these naturally sourced oils could provide a more targeted strategy to protect against intestinal mucositis.

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Section: Introductionmentioning

confidence: 99%

Emu Oil Combined with Lyprinol™ Reduces Small Intestinal Damage in a Rat Model of Chemotherapy-Induced Mucositis

Mashtoub

Lampton

Eden

et al. 2016

Nutrition and Cancer

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“…Neutropenia usually occurs 7–10 days after chemotherapy. It can increase the risk of a complication of infection and fever known as febrile neutropenia (FN) [ 6 ]. In several papers, they consider the prediction of the occurrence of neutropenia in breast cancer patients [ [7] , [8] , [9] ].…”

Section: Introductionmentioning

confidence: 99%

Characteristics of breast cancer patients at dr. Sardjito Hospital for early anticipation of neutropenia: Cross-sectional study

Fathoni

Gunardi

Adi-Kusumo

et al. 2022

Annals of Medicine &Amp; Surgery

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The highest prevalence of breast cancer in Indonesia is in the Province of Yogyakarta. dr. Sardjito General Hospital has quite complete clinical data on breast cancer patients. Characteristics of the population in various regions in Indonesia are different from one another. This problem is the basis for doing this research. Statistical data analysis needs to be done in each area for better diagnosis and treatment of cancer. Data recording is carried out continuously during outpatient treatment at dr. Sardjito General Hospital. Data for breast cancer patients was taken from July 2018 to June 2020. The data obtained were grouped into four categories: laboratory investigation, socio-demographic, clinical examination, and pathology. Descriptive and correlation analysis aims to determine the characteristics of breast cancer patients seeking treatment at dr. Sardjito General Hospital and anticipate their possibility of developing neutropenia after chemotherapy. The results of the descriptive analysis are significant to determine patient characteristics and treatment steps that can be taken. Correlation analysis variables closely related to neutrophils included leucocyte count, lymphocyte, monocyte, albumin, age at first diagnosis, and height. These variables can be a severe concern of medical personnel before undergoing chemotherapy, especially lymphocytes, which have the largest (negative) correlation and can be an early sign of neutropenia.

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“…Neutropenia usually occurs 7 to 10 days after chemotherapy. It can increase the risk of a complication of infection and fever known as febrile neutropenia (FN) [11]. In several papers, they consider the prediction of the occurrence of neutropenia in breast cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Dynamics of a Breast Cancer Model for Neutropenia Case due to Chemotherapy Effects

Fathoni

Adi-Kusumo

Gunardi

et al. 2021

International Journal of Differential Equations

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Breast cancer is a type of carcinoma with a high prevalence. The treatment of breast cancer through chemotherapy can cause a risk to healthy cells throughout the body. The neutrophil is one of the cells that is influenced by chemotherapy drugs. Chemotherapy-induced neutropenia is one of the most common toxic effects experienced by patients and often threatens chemotherapy to use efficiency. In this paper, we introduce an interaction model between blood components, i.e., neutrophil, lymphocytes, and albumin, with chemotherapy drugs. The model is important to understand the neutropenia effect due to chemotherapy in mathematical perspective and to calculate breast cancer patients’ survival level. Our model is a four-dimensional system of the first-order ODE with 13-dimensional parameter space. We focus our study for understanding the steady-state conditions and the bifurcations when the parameter values are varied. Here, we also study the role of albumin for reducing the neutropenia effects for breast cancer patients mathematically, where the results can be used as an alternative solution for treating neutropenia in a breast cancer case.

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Principles of chemotherapy

Cited by 4 publications

References 13 publications

Emu Oil Combined with Lyprinol™ Reduces Small Intestinal Damage in a Rat Model of Chemotherapy-Induced Mucositis

Emu Oil Combined with Lyprinol™ Reduces Small Intestinal Damage in a Rat Model of Chemotherapy-Induced Mucositis

Characteristics of breast cancer patients at dr. Sardjito Hospital for early anticipation of neutropenia: Cross-sectional study

Dynamics of a Breast Cancer Model for Neutropenia Case due to Chemotherapy Effects

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