Principles of magnetodynamic chemotherapy

Babincová, Melánia; Leszczyńska, Danuta; Sourivong, P.; Babinec, Peter; Leszczyński, Jerzy

doi:10.1016/j.mehy.2003.10.003

Cited by 32 publications

(26 citation statements)

References 5 publications

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“…Magnetoliposomes have been used originally to study biological membranes (141) and for cell sorting (142). Furthermore, they can be used for targeted drug delivery (using a constant magnetic field) and controlled release (using high-frequency magnetic field oscillations) of an entrapped drug (143,144). Two types of magnetoliposomes have been used most often.…”

Section: Lipid-based Mri Contrast Agents: Applications Liposomal Contmentioning

confidence: 99%

Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging

et al. 2006

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In the field of MR imaging and especially in the emerging field of cellular and molecular MR imaging, flexible strategies to synthesize contrast agents that can be manipulated in terms of size and composition and that can be easily conjugated with targeting ligands are required. Furthermore, the relaxivity of the contrast agents, especially for molecular imaging applications, should be very high to deal with the low sensitivity of MRI. Lipid-based nanoparticles, such as liposomes or micelles, have been used extensively in recent decades as drug carrier vehicles. A relatively new and promising application of lipidic nanoparticles is their use as multimodal MR contrast agents. Lipids are amphiphilic molecules with both a hydrophobic and a hydrophilic part, which spontaneously assemble into aggregates in an aqueous environment. In these aggregates, the amphiphiles are arranged such that the hydrophobic parts cluster together and the hydrophilic parts face the water. In the low concentration regime, a wide variety of structures can be formed, ranging from spherical micelles to disks or liposomes. Furthermore, a monolayer of lipids can serve as a shell to enclose a hydrophobic core. Hydrophobic iron oxide particles, quantum dots or perfluorocarbon emulsions can be solubilized using this approach. MR-detectable and fluorescent amphiphilic molecules can easily be incorporated in lipidic nanoparticles. Furthermore, targeting ligands can be conjugated to lipidic particles by incorporating lipids with a functional moiety to allow a specific interaction with molecular markers and to achieve accumulation of the particles at disease sites. In this review, an overview of different lipidic nanoparticles for use in MRI is given, with the main emphasis on Gd-based contrast agents. The mechanisms of particle formation, conjugation strategies and applications in the field of contrast-enhanced, cellular and molecular MRI are discussed.

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Section: Lipid-based Mri Contrast Agents: Applications Liposomal Contmentioning

confidence: 99%

Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging

et al. 2006

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“…[6,15] Rather than using derivatised phospholipids, it is also possible to incorporate other hydrophobic compounds, such as drugs that are used for cancer treatment, which leads to a very local and specific release of the drug. [27,28] In addition to drug molecules for cancer treatment, other compounds, for example, cationic lipids, such as 1,2-dioleoyl-3-trimethylammonium propane (DOTAP), can be incorporated into the ML bilayer with high A C H T U N G T R E N N U N G efficiency. [29] The procedure for the preparation of MLs (see Scheme 1), which is outlined in the paper of De Cuyper et al [29] allows for the sensitive modification of the cationic lipid content.…”

Section: Introductionmentioning

confidence: 99%

Optimal Conditions for Labelling of 3T3 Fibroblasts with Magnetoliposomes without Affecting Cellular Viability

2007

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A comparative study that deals with the internalisation of different types of magnetoliposomes (MLs) by 3T3 fibroblasts revealed that cationic MLs proved to be superior to neutral and anionic ones. Internalisation was visualised both by optical light and transmission electron microscopy. The latter showed that the cationic MLs ultimately ended up in lysosomal structures. The effect of increasing 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) concentrations in the cationic ML coat has been elucidated. High uptake efficiency was only achieved with MLs that carry a high DOTAP payload. However, these structures also demonstrated toxic effects. The use of the saturated distearoyl analogue (DSTAP) at identical concentrations led to improved uptake efficiency and lower toxicity. By using iron-oxide-free vesicles, it was shown that the toxicity was due to lipid bilayer constituents and not the iron oxide. In conclusion, the use of DMPC-DSTAP (96.67:3.33; molar ratio) MLs results in an extremely high labelling of 3T3 fibroblasts with iron oxides (47.66 pg Fe per cell) without evoking any influence on cell viability.

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“…This is markedly longer than the delay (4 days) obtained after photodynamic therapy under identical conditions without the pre-irradiation. It is interesting that infrared pulse itself was rather efficient in tumor treatment (9 days delay in tumor growth), which may be explained by laser mediated melanocytes destruction and also by capabilities of C 60 to produce cytotoxic singlet oxygen upon irradiation, via multiphoton infrared light absorption [7].…”

Section: Resultsmentioning

confidence: 99%

“…Recently we have developed fullerenosomes, a novel nanosystem prepared by incorporation of C 60 fullerenes into lipid bilayers of phosphatidylcholine liposomes. As we have shown [5][6][7], single nanosecond near-infrared laser pulse energy absorbed by C 60 leads to explosive release of encapsulated material. Our aim in this study is to show that sterically stabilized long-circulating photosensitized fullerenosomes may substantially improve photodynamic therapy of pigmented B16 melanoma using above mentioned method of laser mediated tumor bleaching.…”

Section: Introductionmentioning

confidence: 90%

Photodynamic therapy of pigmented melanoma B16 using sterically stabilized fullerenosomes

et al. 2004

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Novel multifunctional approach to the therapy of very virulent pigmented melanoma B16 tumor is proposed based on exploitation of fullerenosomes, nanostructures build from sterically stabilized liposomes with incorporated fullerenes C 60 in their lipid bilayers and encapsulated photosensitizer naphthalocyanate. 24 hours after their intravenous administration the melanoma tumors implanted in C57 mice were irradiated with one pulse of 8 ns infrared laser for the bleaching of melanin granules and for the release of photosensitizer and subsequently illuminated with 776 nm diode laser for conventional photodynamic treatment of tumors. Significant tumor response was found which is markedly larger than that obtained with either treatment alone.

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Principles of magnetodynamic chemotherapy

Cited by 32 publications

References 5 publications

Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging

Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging

Optimal Conditions for Labelling of 3T3 Fibroblasts with Magnetoliposomes without Affecting Cellular Viability

Photodynamic therapy of pigmented melanoma B16 using sterically stabilized fullerenosomes

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