Principles of Surgical Oncology

Ehrhart, Nicole; Culp, William T. N.

doi:10.1002/9781118729038.ch1

Cited by 8 publications

(15 citation statements)

References 57 publications

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“…Completeness of surgical margins has been advocated to eliminate one of the possible reasons for wound healing complications . In this study infiltrated surgical margins did not increase the risk of WHC, either minor or major.…”

Section: Discussionmentioning

confidence: 60%

“…However, a risk factor analysis with regards to WHC is warranted, because the development of postoperative morbidity affects the outcome of the patient, implies a financial impact on the owner, and may affect timing of adjuvant therapy . The identification of potential risk factors for WHC during surgical planning may also allow preparation of the owner to anticipated complications and facilitate their rapid detection …”

Section: Discussionmentioning

confidence: 99%

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Factors Influencing Wound Healing Complications After Wide Excision of Injection Site Sarcomas of the Trunk of Cats

et al. 2014

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Factors Influencing Wound Healing Complications After Wide Excision of Injection Site Sarcomas of the Trunk of Cats

et al. 2014

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“…The conventional path to achieving cancer diagnosis in companion animals varies based on patient characteristics, tumor type, and tumor location (122). Fine needle aspiration (FNA) cytology is less invasive and lower risk compared to biopsy, and FNA is often used to make a preliminary or definitive diagnosis, develop a treatment plan, and predict prognosis (123,124).…”

Section: Tumor Tissue Sampling and Analysis As The Current Standard Omentioning

confidence: 99%

Horizons in Veterinary Precision Oncology: Fundamentals of Cancer Genomics and Applications of Liquid Biopsy for the Detection, Characterization, and Management of Cancer in Dogs

Chibuk¹,

Flory²,

Kruglyak³

et al. 2021

Front. Vet. Sci.

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Cancer is the leading cause of death in dogs, in part because many cases are identified at an advanced stage when clinical signs have developed, and prognosis is poor. Increased understanding of cancer as a disease of the genome has led to the introduction of liquid biopsy testing, allowing for detection of genomic alterations in cell-free DNA fragments in blood to facilitate earlier detection, characterization, and management of cancer through non-invasive means. Recent discoveries in the areas of genomics and oncology have provided a deeper understanding of the molecular origins and evolution of cancer, and of the “one health” similarities between humans and dogs that underlie the field of comparative oncology. These discoveries, combined with technological advances in DNA profiling, are shifting the paradigm for cancer diagnosis toward earlier detection with the goal of improving outcomes. Liquid biopsy testing has already revolutionized the way cancer is managed in human medicine – and it is poised to make a similar impact in veterinary medicine. Multiple clinical use cases for liquid biopsy are emerging, including screening, aid in diagnosis, targeted treatment selection, treatment response monitoring, minimal residual disease detection, and recurrence monitoring. This review article highlights key scientific advances in genomics and their relevance for veterinary oncology, with the goal of providing a foundational introduction to this important topic for veterinarians. As these technologies migrate from human medicine into veterinary medicine, improved awareness and understanding will facilitate their rapid adoption, for the benefit of veterinary patients.

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“…Mast cell tumors (MCT) and soft tissue sarcomas (STS) are the most frequently encountered cutaneous and subcutaneous malignancies in dogs 1 . A characteristic behavior shared by both tumor types is for microscopic extension of tumor cells to exist beyond the main tumor bed 2 . As a consequence of this predictable behavior, the mainstay of treatment is wide surgical excision with the goal of obtaining complete tumor excision with an adequate margin of tumor free tissue resection 3 …”

Section: Introductionmentioning

confidence: 99%

“…1 A characteristic behavior shared by both tumor types is for microscopic extension of tumor cells to exist beyond the main tumor bed. 2 As a consequence of this predictable behavior, the mainstay of treatment is wide surgical excision with the goal of obtaining complete tumor excision with an adequate margin of tumor free tissue resection. 3 However, defining the adequate resection margin required to achieve local tumor control is not a straightforward endeavor.…”

Section: Introductionmentioning

confidence: 99%

Variability in tumor margin reporting for soft tissue sarcoma and cutaneous mast cell tumors in dogs: A systematic review

et al. 2020

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To identify which classification systems have been used for tumor margin reporting and to determine whether factors (publication year, tumor type, and specialty of the contributing authors) influenced trends in margin reporting within literature describing canine soft tissue sarcoma (STS) and cutaneous mast cell tumors (MCT). Study design: Systematic literature review. Methods: Eligible articles were identified through electronic database searches performed for STS and MCT. Data abstracted from relevant studies included publication year, author list, specialty of contributing authors, criteria used to report the planned surgical margins, and the status of histologic margins. Categorization of papers was based on the classification systems used to report surgical and histologic tumor margins. Results: Fifty-three articles were included, 11 on STS, 37 on MCT, and five that included both tumor types. Criteria for classifying the planned surgical margins were described in only 50.9% of studies. Articles that listed a veterinary surgeon as a contributing author (P = .01) and STS articles compared to MCT papers (P = .01) were more likely to report surgical margins. Most (56.6%) studies reported the status of histologic margins dichotomously as "complete" or "incomplete." Although a previously published consensus statement recommended that quantitative criteria be used to report histologic margins, only 7.5% of articles used quantitative methods.

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Principles of Surgical Oncology

Cited by 8 publications

References 57 publications

Factors Influencing Wound Healing Complications After Wide Excision of Injection Site Sarcomas of the Trunk of Cats

Factors Influencing Wound Healing Complications After Wide Excision of Injection Site Sarcomas of the Trunk of Cats

Horizons in Veterinary Precision Oncology: Fundamentals of Cancer Genomics and Applications of Liquid Biopsy for the Detection, Characterization, and Management of Cancer in Dogs

Variability in tumor margin reporting for soft tissue sarcoma and cutaneous mast cell tumors in dogs: A systematic review

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