Principles of Tissue Engineering

Akter, F.

doi:10.1016/b978-0-12-805361-4.00002-3

Cited by 24 publications

(13 citation statements)

References 40 publications

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“…With the use of bone tissue engineering (BTE), it is possible to create artificial bone substitutes that have the same, better, or more functional properties as natural bone. BTE currently enables researchers to employ a variety of strategies to mix cells, biomaterials, and biological factors to create synthetic tissues for mending bone abnormalities [ 28 , 29 ]. There are no obvious problems with this method, which has the advantages of great modifiability, low infectivity risk, and excellent biocompatibility [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

A Review on the Role of Wollastonite Biomaterial in Bone Tissue Engineering

Zenebe

2022

BioMed Research International

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Millions of people around the world have bone-tissue defects. Autologous and allogeneic bone grafting are frequent therapeutic techniques; however, none has produced the best therapeutic results. This has inspired researchers to investigate novel bone-regeneration technologies. In recent years, the development of bone tissue engineering (BTE) scaffolds has been at the forefront of this discipline. Due to their limitless supply and lack of disease transmission, engineered bone tissue has been advanced for the repair and reconstruction of bone deformities. Bone tissue is a highly vascularized, dynamic tissue that constantly remodels during an individual’s lifetime. Bone tissue engineering is aimed at stimulating the creation of new, functional bone by combining biomaterials, cells, and factor treatment synergistically. This article provides a review of wollastonite’s biomaterial application in bone tissue engineering. This work includes an explanation of wollastonite minerals including mining, raw materials for the synthesis of artificial wollastonite with various methods, its biocompatibility, and biomedical applications. Future perspectives are also addressed, along with topics like bone tissue engineering, the qualities optimal bone scaffolds must have, and the way a scaffold is designed can have a big impact on how the body reacts.

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Section: Introductionmentioning

confidence: 99%

A Review on the Role of Wollastonite Biomaterial in Bone Tissue Engineering

Zenebe

2022

BioMed Research International

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“…GFs generally used in tissue engineering include bFGF, insulin-like growth factor-1 (IGF-1), transforming growth factor beta (TGF-β), VEGF, and various bone morphogenic proteins (BMPs). Some cytokines (small proteins secreted by one cell to regulate the function of another cell) may also function as GFs [ 46 , 47 ]. They represent a vital component in bioactive coatings as they are responsible for osteoconduction and osseointegration.…”

Section: Bioactive Coatings and Gfsmentioning

confidence: 99%

The Role of Growth Factors in Bioactive Coatings

Bjelić

Finšgar

2021

Pharmaceutics

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With increasing obesity and an ageing population, health complications are also on the rise, such as the need to replace a joint with an artificial one. In both humans and animals, the integration of the implant is crucial, and bioactive coatings play an important role in bone tissue engineering. Since bone tissue engineering is about designing an implant that maximally mimics natural bone and is accepted by the tissue, the search for optimal materials and therapeutic agents and their concentrations is increasing. The incorporation of growth factors (GFs) in a bioactive coating represents a novel approach in bone tissue engineering, in which osteoinduction is enhanced in order to create the optimal conditions for the bone healing process, which crucially affects implant fixation. For the application of GFs in coatings and their implementation in clinical practice, factors such as the choice of one or more GFs, their concentration, the coating material, the method of incorporation, and the implant material must be considered to achieve the desired controlled release. Therefore, the avoidance of revision surgery also depends on the success of the design of the most appropriate bioactive coating. This overview considers the integration of the most common GFs that have been investigated in in vitro and in vivo studies, as well as in human clinical trials, with the aim of applying them in bioactive coatings. An overview of the main therapeutic agents that can stimulate cells to express the GFs necessary for bone tissue development is also provided. The main objective is to present the advantages and disadvantages of the GFs that have shown promise for inclusion in bioactive coatings according to the results of numerous studies.

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“…Immortalization approaches comprise noncovalent, i.e. encapsulation, adsorption, ion complexation, or covalent bindings, depending on properties of both growth factors and substrates [90]. The above-mentioned strategies, when applied without altering growth factors' properties, provide the surveillance of peptides' release.…”

Section: Biochemical Cues In Skeletal Muscle Tissue Engineering Approachesmentioning

confidence: 99%

Extracellular Matrix-Derived Hydrogels as Biomaterial for Different Skeletal Muscle Tissue Replacements

et al. 2020

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Recently, skeletal muscle represents a complex and challenging tissue to be generated in vitro for tissue engineering purposes. Several attempts have been pursued to develop hydrogels with different formulations resembling in vitro the characteristics of skeletal muscle tissue in vivo. This review article describes how different types of cell-laden hydrogels recapitulate the multiple interactions occurring between extracellular matrix (ECM) and muscle cells. A special attention is focused on the biochemical cues that affect myocytes morphology, adhesion, proliferation, and phenotype maintenance, underlining the importance of topographical cues exerted on the hydrogels to guide cellular orientation and facilitate myogenic differentiation and maturation. Moreover, we highlight the crucial role of 3D printing and bioreactors as useful platforms to finely control spatial deposition of cells into ECM based hydrogels and provide the skeletal muscle native-like tissue microenvironment, respectively.

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Principles of Tissue Engineering

Cited by 24 publications

References 40 publications

A Review on the Role of Wollastonite Biomaterial in Bone Tissue Engineering

A Review on the Role of Wollastonite Biomaterial in Bone Tissue Engineering

The Role of Growth Factors in Bioactive Coatings

Extracellular Matrix-Derived Hydrogels as Biomaterial for Different Skeletal Muscle Tissue Replacements

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