Principles of Toxicology

Vandivort, T.C.; Eaton, David L.

doi:10.1016/b978-0-12-801238-3.00203-8

Cited by 28 publications

(3 citation statements)

References 13 publications

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“…In this sense, an important parameter is the therapeutic index (TI), which is a quantitative relationship between the efficacy and safety of a drug [51] . Mathematically, the TI is the ratio between the dose expected to elicit some adverse effect and the dose needed to elicit bioactive effects: [52] …”

Section: Resultsmentioning

confidence: 99%

“…In this sense, an important parameter is the therapeutic index (TI), which is a quantitative relationship between the efficacy and safety of a drug. [51] Mathematically, the TI is the ratio between the dose expected to elicit some adverse effect and the dose needed to elicit bioactive effects: [52] TI ¼ that the tested sample is more active than toxic, while a TI < 1 reflects that the toxic dose is lower than the bioactive dose. All the studied samples had previously demonstrated their high potential to inhibit ChEs.…”

Section: Comparison Of a Salina And Mtt Toxicity Assaysmentioning

confidence: 99%

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Toxicity Evaluation of Anti‐cholinesterasic Amphibian Extracts by MTT and an Optimized Artemia salina Test

Spinelli,

Rietmann,

Sanchis

et al. 2024

Chemistry & Biodiversity

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The amphibian skin is an important source of bioactive compounds. Recently, our workgroup reported the bioactivity of new extracts from the Hylidae, Microhylidae and Leptodactylidae families against several pathways involved in Alzheimer’s disease. However, since cytotoxicity can be a limiting factor for their applicability, we evaluated the toxicity of nine amphibian skin extracts with reported anticholinesterase activity, using the traditional MTT assay and an optimized Artemia salina test. The proposed improvement, guided by experimental design, aims to reduce the amount of biological sample needed. Overall, we proved that the active extracts were non‐toxic at effective concentration against cholinesterases (AChE/BChE), positioning the amphibian skin as a promising and preliminary safe source of bioactive compounds in the anti‐Alzheimer's treatment. Interestingly, we demonstrated that both toxicity assays can discriminate between toxic and non‐toxic samples. We propose the A. salina bioassay as a reliable and cost‐effective alternative for early toxicity screening.

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Section: Resultsmentioning

confidence: 99%

Section: Comparison Of a Salina And Mtt Toxicity Assaysmentioning

confidence: 99%

Toxicity Evaluation of Anti‐cholinesterasic Amphibian Extracts by MTT and an Optimized Artemia salina Test

Spinelli,

Rietmann,

Sanchis

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…Показано, что достижение терапевтического эффекта в популяции на уровне 60 % уже приводит к проявлениям побочных эффектов в «чувствительной» субпопуляции. В отличие от терапевтических эффектов, в побочные реакции, как правило, вовлечено большее количество молекулярных мишеней и биохимических процессов [19]. Полиморфизм генов, кодирующих цитохромы Р450, может выступать в качестве фактора, с которым связаны эти реакции, так как в метаболизме лекарств, применяемых в схемах химиотерапии лимфомы Ходжкина ABVD и BEACOPP участвует большое количество цитохромов Р450 [3].…”

Section: обсуждение / Discussionunclassified