PRINS Long Noncoding RNA Involved in IP-10–Mediated Allograft Rejection in Rat Kidney Transplant

Zou, Xun-feng; Song, Bin; Duan, Jihui; Hu, Zhandong; Z, Cui; Yang, Tao

doi:10.1016/j.transproceed.2018.03.105

Cited by 10 publications

(7 citation statements)

References 32 publications

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“…Circulating lncRNAs can serve as signaling molecules under pathological conditions to induce systemic reactions in patients with diabetes, including insulin resistance and accelerated senescence (18). Upregulation of PRINS was observed following acute tubule damage in rat kidney transplantation (15). The current study demonstrated that PRINS was significantly upregulated in patients with diabetes compared with healthy controls.…”

Section: Discussionsupporting

confidence: 52%

“…Previous findings demonstrated that PRINS is involved in kidney ischemia reperfusion injury (11) and allograft rejection in rat kidney transplantation (15), and therefore PRINS serves important roles in renal damage. In addition, the current study demonstrated that PRINS may be involved in the development of nephropathy in patients with diabetes, and PRINS may exert its biological function by upregulating Smad7 expression.…”

Section: Discussionmentioning

confidence: 96%

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LncRNA PRINS is involved in the development of nephropathy in patients with diabetes via interaction with Smad7

Xie

Qiao

2019

Exp Ther Med

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Long non-coding RNA psoriasis-susceptibilityrelated RNA gene induced by stress (PRINS) is known to be involved in kidney ischemia reperfusion injury. The aim of the current study was to investigate the potential role of PRINS in diabetic nephropathy. The relative mRNA expression level of PRINS and SMAD family member 7 (Smad7) was examined in patients with diabetes, including patients without obvious complications (n=43), patients with diabetic nephropathy (n=33), diabetic retinopathy (n=37), diabetic cardiomyopathy (n=29), diabetic lung disease (n=38) and healthy controls (n=48). Correlation analysis between the expression level of PRINS and Smad7 was analyzed by Pearson's correlation analysis. In addition, overexpression of PRINS was confirmed in mouse podocyte cells and cell viability and Smad7 protein expression was detected by MTT assay and western blot analysis, respectively. The expression levels of PRINS and Smad7 were significantly increased in patients with diabetes compared with healthy controls. In addition, the expression levels of PRINS and Smad7 were significantly increased in patients with diabetic nephropathy compared with other diabetic complications. The expression level of PRINS in mouse podocyte cells was upregulated following treatment with high glucose. A significant positive correlation between the expression level of PRINS and Smad7 was observed in patients with diabetic nephropathy. However, there was no correlation was observed in other patient groups compared with healthy controls. Overexpression of PRINS decreased the viability of mouse podocyte cells and enhanced Smad7 protein expression. Taken together, these results suggest that PRINS may be involved in the development of nephropathy in patients with diabetes.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 96%

LncRNA PRINS is involved in the development of nephropathy in patients with diabetes via interaction with Smad7

Xie

Qiao

2019

Exp Ther Med

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“…PRINS is also involved in the immune mechanisms, and its expression level is related to chemokines [ 38 ]. In a rat model, it affects the immune response and mechanisms of kidney transplant rejection [ 39 ]. PRINS has been demonstrated to function as a hypoxia-responsive lncRNA in renal epithelial cells and participates in chemokine CCL5 regulation in hypoxic conditions [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

PRINS lncRNA Is a New Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas

et al. 2020

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Numerous studies have shown that human papillomavirus (HPV) infection is one of the important risk factors for head and neck squamous cell carcinoma (HNSCC) progression and affects the expression of multiple genes, which might serve as new biomarkers. This study examines the effects of HPV infection on long non-coding RNA (lncRNA) expression and the immune system, particularly PRINS (Psoriasis susceptibility-related RNA Gene Induced by Stress). The Cancer Genome Atlas (TCGA) expression data for lncRNA genes and clinical data were analyzed by GraphPad Prism 5/7. The expressions of PRINS, CDKN2B-AS1, TTTY14, TTTY15, MEG3, and H19 were significantly different in HPV-positive and HPV-negative patients. HPV-positive patients with high PRINS expression demonstrated significantly better overall survival (OS) and disease-free survival (DFS). HPV-positive patients with high PRINS expression showed changes in gene expression associated with immune and antiviral responses. A majority of HPV-positive patients with high PRINS expression demonstrated a high number of immune cells within tumors. PRINS expression was significantly associated with HPV-infection HNSCC tumors. Validation of these results using data set from Gene Expression Omnibus (GEO) indicated that PRINS is upregulated in HPV active infections and in “atypical 1 (IR)” HNSCC clusters, negatively influencing patients’ overall survival. Patients with high PRINS expression display different immunological profiles than those with low expression levels. For instance, they have active HPV infection status or are clustered in the “atypical 1 (IR)” subtype of HNSCC which influences both viral infection and patients’ survival. It is likely that PRINS could be used as a potential biomarker for HNSCC patients, but its role is dual. On the one hand, it stimulates patients’ immune response, while on the other it can be favorable in virus replication.

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“…This is in line with two other studies that showed an association between lncRNAs and AR that suggested their value for diagnosis of AR in kidney transplantation [ 21 , 22 ]. Moreover, in a rat study, the lncRNA PRINS was shown to be significantly up-regulated in kidneys of rats with cold ischemia-elicited allograft rejection, compared with rats without rejection [ 23 ]. In addition, lncRNAs may also be of value in predicting the development of chronic damage after kidney transplantation [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Circulating Long Noncoding RNA LNC-EPHA6 Associates with Acute Rejection after Kidney Transplantation

Groeneweg

Duijs

Florijn

et al. 2020

IJMS

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Acute rejection (AR) of a kidney graft in renal transplant recipients is associated with microvascular injury in graft dysfunction and, ultimately, graft failure. Circulating long noncoding RNAs (lncRNAs) may be suitable markers for vascular injury in the context of AR. Here, we first investigated the effect of AR after kidney transplantation on local vascular integrity and demonstrated that the capillary density markedly decreased in AR kidney biopsies compared to pre-transplant biopsies. Subsequently, we assessed the circulating levels of four lncRNAs (LNC-RPS24, LNC-EPHA6, MALAT1, and LIPCAR), that were previously demonstrated to associate with vascular injury in a cohort of kidney recipients with a stable kidney transplant function (n = 32) and recipients with AR (n = 15). The latter were followed longitudinally six and 12 months after rejection. We found higher levels of circulating LNC-EPHA6 during rejection, compared with renal recipients with a stable kidney function (p = 0.017), that normalized one year after AR. In addition, LNC-RPS24, LNC-EPHA6, and LIPCAR levels correlated significantly with the vascular injury marker soluble thrombomodulin. We conclude that AR and microvascular injury are associated with higher levels of circulating LNC-EPHA6, which emphasizes the potential role of lncRNAs as biomarker in the context of AR.

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PRINS Long Noncoding RNA Involved in IP-10–Mediated Allograft Rejection in Rat Kidney Transplant

Cited by 10 publications

References 32 publications

LncRNA PRINS is involved in the development of nephropathy in patients with diabetes via interaction with Smad7

LncRNA PRINS is involved in the development of nephropathy in patients with diabetes via interaction with Smad7

PRINS lncRNA Is a New Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas

Circulating Long Noncoding RNA LNC-EPHA6 Associates with Acute Rejection after Kidney Transplantation

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