Printed microfluidic sweat sensing platform for cortisol and glucose detection

Naik, Aditi R.; Zhou, Yiliang; Dey, Anita A.; Arellano, David; Okoroanyanwu, Uzodinma; Secor, Ethan B.; Hersam, Mark C.; Morse, Jeffrey; Rothstein, Jonathan P.; Carter, Kenneth R.; Watkins, James J.

doi:10.1039/d1lc00633a

Cited by 59 publications

(48 citation statements)

References 73 publications

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“…As shown in Figure S14b, the sensor responded faster when the external humidity was lower as the solution in the filer paper channels moved faster for a quick evaporation rate under lower humidity. However, the final detected potential value did not change, which is consistent with the former results. − …”

Section: Resultssupporting

confidence: 90%

Paper-Based Sandwich-Structured Wearable Sensor with Sebum Filtering for Continuous Detection of Sweat pH

et al. 2023

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Wearable sweat sensors, a product of the development of flexible electronics and microfluidic technologies, can continuously and noninvasively monitor abundant biomarkers in human sweat; however, sweat interferences, such as sebum, can reduce sensor reliability and accuracy. Herein, for the first time, the influence of sebum on the potentiometric response of an all-solidstate pH sensor was studied, and the obtained experimental results show that sebum mixed in sweat can decrease the potential response of the sensor and the slope of its calibration curve. A paper-based sandwich-structured pH sensor that can filter the sebum mixed in sweat was proposed based on commonly used oilcontrol sheets. Moreover, the hydrophilic properties, microstructure, and microfluidic performance of the sensor were investigated. The detection performance of the paper-based sandwich-structured pH sensor was comprehensively evaluated in terms of calibration in the presence of sebum and potentiometric response upon the addition of sebum. Furthermore, the antiinterference ability of the sensor was evaluated using different analytes under various deformation conditions. On-body trials were conducted to verify the performance, and their results showed that the proposed sensor can filter over 90% of the sebum in sweat, significantly enhancing sensor reliability and accuracy. Additionally, microfluidic channels could be simply fabricated using a scissor and paper, obviating the need for complex micromachining processes, such as photolithography and laser engraving. Overall, this work illustrates the influence of sebum on the detection performance of traditional potentiometric wearable sensors and paves the way for their development for real-world applications.

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Section: Resultssupporting

confidence: 90%

Paper-Based Sandwich-Structured Wearable Sensor with Sebum Filtering for Continuous Detection of Sweat pH

et al. 2023

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“…However, current wearable sweat sensors are limited by the lack of available data revealing the effect of sweat volume flow rates [187], the mixture of old and new sweat that reduces sensor reliability [188], and above all, the requirement for expensive and complex fabrication techniques such as photolithography. Very recently, Naik et al [189] demonstrated the fabrication of a "smart bandage" microfluidic device for single-use cortisol detection and glucose sensing and monitoring. The device was composed of electrochemical sensorprinted graphene and silver inks and an adhesive-based microchannel.…”

Section: Enzymatic Biosensormentioning

confidence: 99%

Inkjet Printing: A Viable Technology for Biosensor Fabrication

2022

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Printing technology promises a viable solution for the low-cost, rapid, flexible, and mass fabrication of biosensors. Among the vast number of printing techniques, screen printing and inkjet printing have been widely adopted for the fabrication of biosensors. Screen printing provides ease of operation and rapid processing; however, it is bound by the effects of viscous inks, high material waste, and the requirement for masks, to name a few. Inkjet printing, on the other hand, is well suited for mass fabrication that takes advantage of computer-aided design software for pattern modifications. Furthermore, being drop-on-demand, it prevents precious material waste and offers high-resolution patterning. To exploit the features of inkjet printing technology, scientists have been keen to use it for the development of biosensors since 1988. A vast number of fully and partially inkjet-printed biosensors have been developed ever since. This study presents a short introduction on the printing technology used for biosensor fabrication in general, and a brief review of the recent reports related to virus, enzymatic, and non-enzymatic biosensor fabrication, via inkjet printing technology in particular.

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“…The antibody-containing detection component of the patch can be disassembled after use, and a new component can be put in the patch for the next cortisol detection on demand. Cortisol detection electrodes can be printed on a flexible bandage as shown in Figure 5C [47]. Ag and graphene inks were printed on a polymeric substrate (polyimide) to form reference and counter electrodes, respectively.…”

Section: Wearable Sensors For Detecting Molecular Biomarkersmentioning

confidence: 99%

“…Cortisol detection electrodes can be printed on a flexible bandage as shown in Figure 5 C [ 47 ]. Ag and graphene inks were printed on a polymeric substrate (polyimide) to form reference and counter electrodes, respectively.…”

Section: Wearable Sensors For Detecting Molecular Biomarkersmentioning

confidence: 99%

Wearable Sensing Systems for Monitoring Mental Health

Kang

Chai

2022

Sensors

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Wearable systems for monitoring biological signals have opened the door to personalized healthcare and have advanced a great deal over the past decade with the development of flexible electronics, efficient energy storage, wireless data transmission, and information processing technologies. As there are cumulative understanding of mechanisms underlying the mental processes and increasing desire for lifetime mental wellbeing, various wearable sensors have been devised to monitor the mental status from physiological activities, physical movements, and biochemical profiles in body fluids. This review summarizes the recent progress in wearable healthcare monitoring systems that can be utilized in mental healthcare, especially focusing on the biochemical sensors (i.e., biomarkers associated with mental status, sensing modalities, and device materials) and discussing their promises and challenges.

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Printed microfluidic sweat sensing platform for cortisol and glucose detection

Abstract: An inexpensive microfluidic sweat sensor platform for single-use and continuous biomarker measurements integrated with a synthetic skin for characterization at various sweat rates.

Cited by 59 publications

References 73 publications

Paper-Based Sandwich-Structured Wearable Sensor with Sebum Filtering for Continuous Detection of Sweat pH

Paper-Based Sandwich-Structured Wearable Sensor with Sebum Filtering for Continuous Detection of Sweat pH

Inkjet Printing: A Viable Technology for Biosensor Fabrication

Wearable Sensing Systems for Monitoring Mental Health

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