Printing 3D vagina tissue analogues with vagina decellularized extracellular matrix bioink

Hou, Chenxiao; Zheng, Jia‐Hua; Li, Zhongkang; Qi, Xuejun; Tian, Yanpeng; Zhang, Mingle; Zhang, Jingkun; Huang, Xianghua

doi:10.1016/j.ijbiomac.2021.03.070

Cited by 47 publications

(37 citation statements)

References 38 publications

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“…Recent work converted decellularized scaffolds from reproductive organs into ECM hydrogels ( Table 1 ), which, as discussed in Section 2.1 , have the main advantage of being able to conform to the shape of any defect site, since they are first injected as a viscous fluid (pre-gel) and finally polymerize into a 3D structure (hydrogel) at physiological temperature [ 55 ]. The development of ECM hydrogels from the female reproductive tract is still nascent, but promising results include the formation of hydrogels from decellularized uterus [ 40 , 52 , 106 , 107 ], ovary [ 108 , 109 ], oviduct [ 110 ], vagina [ 111 ], and placenta [ 112 , 113 , 114 ] ( Table 1 ).…”

Section: Deriving Ecm Hydrogels From Reproductive Organsmentioning

confidence: 99%

“…The vagina is a fibromuscular elastic tubular tract which connects the uterus and cervix to the outside of the body, allowing for menstruation, intercourse, and childbirth. The absence of this organ, due to congenital or acquired factors, can cause patients to suffer physical and mental pain and prevents normal sexual and reproductive processes [ 111 ].…”

Section: Deriving Ecm Hydrogels From Reproductive Organsmentioning

confidence: 99%

“…Thanks to bioengineering technology, ECM products exist for vaginal reconstruction, such as vaginal ECM scaffolds [ 94 , 95 ] and hydrogels [ 111 ]. For vaginal ECM decellularization, several authors used the immersion protocol with chemical and enzymatic agents.…”

Section: Deriving Ecm Hydrogels From Reproductive Organsmentioning

confidence: 99%

“…For vaginal ECM decellularization, several authors used the immersion protocol with chemical and enzymatic agents. However, prior (manual) removal of the mucosal and/or muscularis layers is important for better permeabilization of chemicals [ 94 , 111 ]. In the studies that have been carried out to date, the pig is the animal species of election par excellence given its phylogenetic proximity, the ease to obtain the raw material, and its similar female anatomy.…”

Section: Deriving Ecm Hydrogels From Reproductive Organsmentioning

confidence: 99%

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Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive Medicine

Francés-Herrero

Rodríguez-Eguren

Gómez-Álvarez

et al. 2022

IJMS

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Bioengineering and reproductive medicine have progressed shoulder to shoulder for several decades. A key point of overlap is the development and clinical translation of technologies to support reproductive health, e.g., scaffold-free constructs, polymeric scaffolds, bioprinting or microfluidics, and hydrogels. Hydrogels are the focus of intense study, and those that are derived from the extracellular matrix (ECM) of reproductive tissues and organs are emerging as promising new players given their results in pre-clinical models. This literature review addresses the recent advances in the use of organ-specific ECM hydrogels in reproductive medicine, considering the entire female reproductive tract. We discuss in-depth papers describing the development of ECM hydrogels, their use in in vitro models, and their in vivo application in preclinical studies. We also summarize the functions of hydrogels, including as grafts, carriers for cell transplantation, or drug depots, and present the potential and possible scope for use of ECM hydrogels in the near future based on recent scientific advances.

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Section: Deriving Ecm Hydrogels From Reproductive Organsmentioning

confidence: 99%

Section: Deriving Ecm Hydrogels From Reproductive Organsmentioning

confidence: 99%

Section: Deriving Ecm Hydrogels From Reproductive Organsmentioning

confidence: 99%

Section: Deriving Ecm Hydrogels From Reproductive Organsmentioning

confidence: 99%

See 2 more Smart Citations

Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive Medicine

Francés-Herrero

Rodríguez-Eguren

Gómez-Álvarez

et al. 2022

IJMS

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“… big and smart gynecology. 3D gynecology (which is the application of bioengineering and additive manufacturing processes to deposit bio-active materials, known as bio-inks, in order to develop and create tissue-like structures for regenerative or other medical purposes) [ 5 ]. …”

Section: Theoretical Background: the Current Medical Era As The “Disruptive Innovation Era”mentioning

confidence: 99%

Gynecology Meets Big Data in the Disruptive Innovation Medical Era: State-of-Art and Future Prospects

Khamisy‐Farah

Furstenau

Kong

et al. 2021

IJERPH

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Tremendous scientific and technological achievements have been revolutionizing the current medical era, changing the way in which physicians practice their profession and deliver healthcare provisions. This is due to the convergence of various advancements related to digitalization and the use of information and communication technologies (ICTs)—ranging from the internet of things (IoT) and the internet of medical things (IoMT) to the fields of robotics, virtual and augmented reality, and massively parallel and cloud computing. Further progress has been made in the fields of addictive manufacturing and three-dimensional (3D) printing, sophisticated statistical tools such as big data visualization and analytics (BDVA) and artificial intelligence (AI), the use of mobile and smartphone applications (apps), remote monitoring and wearable sensors, and e-learning, among others. Within this new conceptual framework, big data represents a massive set of data characterized by different properties and features. These can be categorized both from a quantitative and qualitative standpoint, and include data generated from wet-lab and microarrays (molecular big data), databases and registries (clinical/computational big data), imaging techniques (such as radiomics, imaging big data) and web searches (the so-called infodemiology, digital big data). The present review aims to show how big and smart data can revolutionize gynecology by shedding light on female reproductive health, both in terms of physiology and pathophysiology. More specifically, they appear to have potential uses in the field of gynecology to increase its accuracy and precision, stratify patients, provide opportunities for personalized treatment options rather than delivering a package of “one-size-fits-it-all” healthcare management provisions, and enhance its effectiveness at each stage (health promotion, prevention, diagnosis, prognosis, and therapeutics).

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Advancements in Bioprinting for Medical Applications

Wu,

Joly‐Chevrier,

Gorwill

et al. 2024

3D Bioprinting From Lab to Industry

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Printing 3D vagina tissue analogues with vagina decellularized extracellular matrix bioink

Cited by 47 publications

References 38 publications

Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive Medicine

Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive Medicine

Gynecology Meets Big Data in the Disruptive Innovation Medical Era: State-of-Art and Future Prospects

Advancements in Bioprinting for Medical Applications

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