Despite
major technological advances within the field of cardiovascular
engineering, the risk of thromboembolic events on artificial surfaces
in contact with blood remains a major challenge and limits the functionality
of ventricular assist devices (VADs) during mid- or long-term therapy.
Here, a biomimetic blood–material interface is created via
a nanofiber-based approach that promotes the endothelialization capability
of elastic silicone surfaces for next-generation VADs under elevated
hemodynamic loads. A blend fiber membrane made of elastic polyurethane
and low-thrombogenic poly(vinylidene fluoride-co-hexafluoropropylene)
was partially embedded into the surface of silicone films. These blend
membranes resist fundamental irreversible deformation of the internal
structure and are stably attached to the surface, while also exhibiting
enhanced antithrombotic properties when compared to bare silicone.
The composite material supports the formation of a stable monolayer
of endothelial cells within a pulsatile flow bioreactor, resembling
the physiological in vivo situation in a VAD. The nanofiber surface
modification concept thus presents a promising approach for the future
design of advanced elastic composite materials that are particularly
interesting for applications in contact with blood.