Prions

Prusiner, Stanley B.

doi:10.1002/3527600906.mcb.200400151

Cited by 1 publication

(3 citation statements)

References 328 publications

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“…In Germany, Figure 1. Timeline of research development of viroids (green text) [4,, satellite RNAs (orange text) [11,12,[45][46][47][48][49], prions (red text) [7,[50][51][52][53][54][55][56][57][58][59][60][61][62][63], and a few general hallmarks (black text) [64].…”

Section: Viroidsmentioning

confidence: 99%

“…Using some viroid research approaches, Riesner and colleagues applied the quantitative methods of nucleic acid analysis-even counting single molecules-and showed in systematic and extended studies that highly infectious samples from hamster brains contained more infectious units than nucleic acid molecules longer than 25 nucleotides [57,58]. We will not outline the whole research development on prions here; Prusiner was awarded the Nobel Prize "for his discovery of Prions-a new biological principle of infection" [56] in 1997, and the final molecular proof was found in 2004 when a synthetic prion-i. e., a synthetic protein that never has seen an animal-was created [55,90].…”

Section: Prionsmentioning

confidence: 99%

“…Figure 1 shows a timeline of discoveries focused on this article's topics. [11,12,[45][46][47][48][49], prions (red text) [7,[50][51][52][53][54][55][56][57][58][59][60][61][62][63], and a few general hallmarks (black text) [64].…”

Section: Introductionmentioning

confidence: 99%

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Viroids, Satellite RNAs and Prions: Folding of Nucleic Acids and Misfolding of Proteins

Steger,

Riesner,

Prusiner

2024

Viruses

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Theodor (“Ted”) Otto Diener (* 28 February 1921 in Zürich, Switzerland; † 28 March 2023 in Beltsville, MD, USA) pioneered research on viroids while working at the Plant Virology Laboratory, Agricultural Research Service, USDA, in Beltsville. He coined the name viroid and defined viroids’ important features like the infectivity of naked single-stranded RNA without protein-coding capacity. During scientific meetings in the 1970s and 1980s, viroids were often discussed at conferences together with other “subviral pathogens”. This term includes what are now called satellite RNAs and prions. Satellite RNAs depend on a helper virus and have linear or, in the case of virusoids, circular RNA genomes. Prions, proteinaceous infectious particles, are the agents of scrapie, kuru and some other diseases. Many satellite RNAs, like viroids, are non-coding and exert their function by thermodynamically or kinetically controlled folding, while prions are solely host-encoded proteins that cause disease by misfolding, aggregation and transmission of their conformations into infectious prion isoforms. In this memorial, we will recall the work of Ted Diener on subviral pathogens.

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