Prior caloric restriction increases survival of prepubertal obese- and PCOS-prone rats exposed to a challenge of time-limited feeding and physical activity

Diané, Abdoulaye; Vine, Donna F.; Heth, C. Donald; Russell, James C.; Proctor, Spencer D.; Pierce, W. David

doi:10.1152/japplphysiol.01127.2012

Cited by 6 publications

(1 citation statement)

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“…In the PCOS-prone model, we have shown that energy restriction and voluntary exercise intervention (4 h/day) at an early life stage can significantly attenuate reproductive and cardiometabolic aberrations ( 111 ). The combination of diet and exercise was shown to lower total body weight gain and body fat mass by 30% in PCOS-prone animals.…”

Section: The Female Jcr:la-cp Rat As a Model Of Pomentioning

confidence: 99%

Mechanisms of Comorbidities Associated With the Metabolic Syndrome: Insights from the JCR:LA-cp Corpulent Rat Strain

et al. 2016

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Obesity and its metabolic complications have emerged as the epidemic of the new millennia. The use of obese rodent models continues to be a productive component of efforts to understand the concomitant metabolic complications of this disease. In 1978, the JCR:LA-cp rat model was developed with an autosomal recessive corpulent (cp) trait resulting from a premature stop codon in the extracellular domain of the leptin receptor. Rats that are heterozygous for the cp trait are lean-prone, while those that are homozygous (cp/cp) spontaneously display the pathophysiology of obesity as well as a metabolic syndrome (MetS)-like phenotype. Over the years, there have been formidable scientific contributions that have originated from this rat model, much of which has been reviewed extensively up to 2008. The premise of these earlier studies focused on characterizing the pathophysiology of MetS-like phenotype that was spontaneously apparent in this model. The purpose of this review is to highlight areas of recent advancement made possible by this model including; emerging appreciation of the “thrifty gene” hypothesis in the context of obesity, the concept of how chronic inflammation may drive obesogenesis, the impact of acute forms of inflammation to the brain and periphery during chronic obesity, the role of dysfunctional insulin metabolism on lipid metabolism and vascular damage, and the mechanistic basis for altered vascular function as well as novel parallels between the human condition and the female JCR:LA-cp rat as a model for polycystic ovary disease (PCOS).

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Section: The Female Jcr:la-cp Rat As a Model Of Pomentioning

confidence: 99%

Mechanisms of Comorbidities Associated With the Metabolic Syndrome: Insights from the JCR:LA-cp Corpulent Rat Strain

et al. 2016

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Emerging functions of adipokines in linking the development of obesity and cardiovascular diseases

Peng

2020

Mol Biol Rep

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How to choose the suitable animal model of polycystic ovary syndrome?

Tamadon

Cui

et al. 2018

Tradit. Med. Mod. Med.

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Polycystic ovary syndrome (PCOS) is a gynecological metabolic and endocrine disorder with uncertain etiology. To understand the etiology of PCOS or the evaluation of various therapeutic agents, different animal models have been introduced. Considering this fact that is difficult to develop an animal model that mimics all aspects of this syndrome, but, similarity of biological, anatomical, and/or biochemical features of animal model to the human PCOS phenotypes can increase its application. This review paper evaluates the recently researched animal models and introduced the best models for different research purposes in PCOS studies. During January 2013 to January 2017, 162 studies were identified which applied various kinds of animal models of PCOS including rodent, primate, ruminant and fish. Between these models, prenatal and pre-pubertal androgen rat models and then prenatal androgen mouse model have been studied in detail than others. The comparison of main features of these models with women PCOS demonstrates higher similarity of these three models to human conditions. Thereafter, letrozole models can be recommended for the investigation of various aspects of PCOS. Interestingly, similarity of PCOS features of post-pubertal insulin and human chorionic gonadotropin rat models with women PCOS were considerable which can make it as a good choice for future investigations.

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Prior caloric restriction increases survival of prepubertal obese- and PCOS-prone rats exposed to a challenge of time-limited feeding and physical activity

Abstract: Diane A, Vine DF, Heth CD, Russell JC, Proctor SD, Pierce WD. Prior caloric restriction increases survival of prepubertal obese-and PCOS-prone rats exposed to a challenge of time-limited feeding and physical activity.

Cited by 6 publications

References 44 publications

Mechanisms of Comorbidities Associated With the Metabolic Syndrome: Insights from the JCR:LA-cp Corpulent Rat Strain

Mechanisms of Comorbidities Associated With the Metabolic Syndrome: Insights from the JCR:LA-cp Corpulent Rat Strain

Emerging functions of adipokines in linking the development of obesity and cardiovascular diseases

How to choose the suitable animal model of polycystic ovary syndrome?

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