Prior electrical stimulation of the inferior colliculus sensitizes rats to the stress of the elevated plus-maze test

Pandossio, José Eduardo; Molina, Vı́ctor A.; Brandão, Marcus Lira

doi:10.1016/s0166-4328(99)00154-0

Cited by 13 publications

(9 citation statements)

References 46 publications

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“…Furthermore, we have shown that electrical stimulation of the IC of rats in intensity sufficient to induce escape behavior enhances subsequent fear-like behaviors when behaviorally tested in the elevated plusmaze test (Pandossio et al, 2000).…”

Section: Discussionmentioning

confidence: 96%

Apomorphine Enhances Conditioned Responses Induced by Aversive Stimulation of the Inferior Colliculus

Troncoso¹,

Osaki²,

Mason³

et al. 2003

Neuropsychopharmacol

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Consistent evidence has shown that learning may be produced in paradigms using electrical stimulation of the inferior colliculus (IC) as unconditioned stimulus (UCS). Recent reports have also demonstrated that aversive stimulation of the IC, at the escape threshold, enhances dopamine (DA) release in the prefrontal cortex. The purpose of the present study was to determine whether dopaminergic mechanisms are involved in the Pavlovian conditioning and latent inhibition using IC stimulation as UCS and light as conditioned stimulus (CS). Rats were placed inside a shuttle box and subjected to a two-way avoidance paradigm. IC aversive electrical stimulation was used as UCS and shuttle box illumination as CS. The rats quickly learned to avoid or interrupt the IC stimulation. Apomorphine injections produced a dose-dependent increase in the number of avoidance responses. On the other hand, chlorpromazine administration promoted a dose-dependent reduction of the avoidance responses. Previous injections of chlorpromazine inhibited the effects of apomorphine. Also, previous exposure to unreinforced light weakened the strength of the conditioning. Apomorphine blocked this latent inhibition effect, which was antagonized by previous injections of chlorpromazine. These findings bring evidence for the involvement of DA in the setting up of adaptive responses to aversive states generated at the IC level, which may underlie stressful situations present in anxiety.

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Section: Discussionmentioning

confidence: 96%

Apomorphine Enhances Conditioned Responses Induced by Aversive Stimulation of the Inferior Colliculus

Troncoso¹,

Osaki²,

Mason³

et al. 2003

Neuropsychopharmacol

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show abstract

“…The midbrain tectum is rich in GABAergic neurons [Pandossio et al, 2000;Bueno et al, 2005a] and a number of animal studies have shown GABAergic drugs affect the midbrain tectum and alter stressrelated anxiety-like behavioral responses, while certain neurochemical or morphological alterations in this brain area have been found in animal depression-like states (Table 6). As such, although clinical studies are still needed to confirm this notion, it seems possible Clinical data Amygdala a Activation in patients with posttraumatic stress disorder [Rauch et al, 1996], during anticipatory anxiety [Phelps et al, 2001], in adults and adolescents viewing fearful faces; also positive correlation of amygdalar activation and social anxiety scores [Morris et al, 1998;Killgore and Yurgelun-Todd, 2005].…”

Section: Brain Circuits Of Anxiety and Depressionmentioning

confidence: 99%

Role of GABA in anxiety and depression

2007

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This review assesses the parallel data on the role of gamma-aminobutyric acid (GABA) in depression and anxiety. We review historical and new data from both animal and human experimentation which have helped define the key role for this transmitter in both these mental pathologies. By exploring the overlap in these conditions in terms of GABAergic neurochemistry, neurogenetics, brain circuitry, and pharmacology, we develop a theory that the two conditions are intrinsically interrelated. The role of GABAergic agents in demonstrating this interrelationship and in pointing the way to future research is discussed.

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“…Moreover, systemic or local injections of GABA agonists or benzodiazepines in this midbrain structure promptly reduce the aversive consequences of electrical stimulation . GABA, serotonin, and excitatory amino acids have been shown to be involved in the mediation of defensive behavior generated and organized at this mesencephalic level (Brandao et al, 1988aBagri et al, 1989;Cardoso et al, 1992Pandossio and Brandao, 2000).…”

Section: Discussionmentioning

confidence: 99%

Papel dos mecanismos GABAérgicos do colículo inferior e da substância cinzenta periaquedutal na interface sensoriomotora do medo e ansiedade

Saito¹

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Prior electrical stimulation of the inferior colliculus sensitizes rats to the stress of the elevated plus-maze test

Cited by 13 publications

References 46 publications

Apomorphine Enhances Conditioned Responses Induced by Aversive Stimulation of the Inferior Colliculus

Apomorphine Enhances Conditioned Responses Induced by Aversive Stimulation of the Inferior Colliculus

Role of GABA in anxiety and depression

Papel dos mecanismos GABAérgicos do colículo inferior e da substância cinzenta periaquedutal na interface sensoriomotora do medo e ansiedade

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