Prior expectation enhances sensorimotor behavior by modulating population tuning and subspace activity in sensory cortex

Park, JeongJun; Kim, S; Kim, HyungGoo R.; Lee, Joonyeol

doi:10.1126/sciadv.adg4156

Cited by 5 publications

(3 citation statements)

References 80 publications

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“…Our study appreciated the Neuropixels probe and found that the prior-value representations were distributed across cortical areas. As the prior knowledge about the task is essential not only for executing action at the late stage of decision processing but also for modulating sensory processing 55 or for predictive coding based on prediction errors 56–58 , the global prior representations are possibly important for various steps of decision making.…”

Section: Discussionmentioning

confidence: 99%

Localized and global representation of prior value, sensory evidence, and choice in male mouse cerebral cortex

Ishizu

Nishimoto

Funamizu

2023

Preprint

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Adaptive behavior requires integrating prior knowledge of action outcomes and sensory evidence for making decisions while maintaining prior knowledge for future actions. As outcome- and sensory-based decisions are often tested separately, it is unclear how these processes are integrated in the brain. In a tone frequency discrimination task with two sound durations and asymmetric reward blocks, we found that a temporal sequence of neurons in the medial prefrontal cortex of mice updated the prior reward expectations with incoming sensory inputs to compute sensory-confidence-dependent action values. The sensory inputs and choices were selectively decoded from the auditory cortex irrespective of reward priors and the secondary motor cortex, respectively, suggesting localized computations of task variables are required within single trials. In contrast, all the recorded regions represented prior values that needed to be maintained across trials. These results propose localized and global computations of task variables in different time scales in the cerebral cortex.

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Section: Discussionmentioning

confidence: 99%

Localized and global representation of prior value, sensory evidence, and choice in male mouse cerebral cortex

Ishizu

Nishimoto

Funamizu

2023

Preprint

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“…For the sake of this paper, it is not necessary to explore in any great depth how priors and sensory data interact in attentional perception (cf., Harrison, 2023;Park, 2023). Rather, we can simply stress that so-called exogenous attention ought not be taken as a purely passive phenomenon.…”

Section: Equation 1 Variational Free Energy Equationmentioning

confidence: 96%

How preferences enslave attention: calling into question the endogenous/exogenous distinction from an active inference perspective

Parvizi-Wayne

2024

Preprint

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It is easy to think of attention as a sensory mechanism divorced from the influence of an agent’s preferences and needs. However, according to active inference, such strict divisions cannot be invoked, since all cognitive and behavioural processes can be described as maximising the evidence for an agent’s generative model, which entails preferences that make an entity the thing it is. As such, attention — and perception more broadly — is constrained or enslaved by prior beliefs for which an agent must seek evidence. This paper demonstrates that this imperative is always at play in cognitive systems endowed with attentional schema, and that the preferences in question transcend the contingent, task-relevant goals that bias attention. Rather, attention is powerfully tuned by the most-deep rooted priors the agent possesses, such that, when sensory evidence against these priors is observed and free energy spikes, the agent attentionally prioritises the homeostatic restoration of these preferred states over their shorter-term desires. Thus, at its core, attention is a goal-driven process, which calls into question the putative distinction between endogenous – goal-directed, top-down – attention and exogenous – bottom-up, stimulus-driven, automatic – attention. What emerges in its place is a symbiotic relationship between attention and preferences, whereby the fulfilment of the latter rests on successful application of the former, and the former derives its function from the organismic need to confirm the latter.

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“…In this study, we leveraged the concept of neural subspaces and a narrative movie stimulus to investigate the coordination of memory processes. To identify neural subspaces associated with memory processes, we applied targeted dimensionality reduction [30][31][32] (TDR) to fMRI blood oxygenation level-dependent (BOLD) data acquired as participants viewed a movie and subsequently recalled its narrative. TDR has been widely used in electrophysiology for extracting low-dimensional subspaces that describe cognitive processes of interest.…”

Section: Introductionmentioning

confidence: 99%

Coordinated Computations for Naturalistic Memory Encoding and Retrieval in Hippocampal Neural Subspaces

Shim,

Kwon,

Kim

et al. 2024

Preprint

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Our naturalistic experiences are organized into memories through multiple processes, including novelty encoding, memory formation, and retrieval. However, the neural mechanisms coordinating these processes remain elusive. Using fMRI data acquired during movie viewing and subsequent narrative recall, we examined hippocampal neural subspaces associated with distinct memory processes and characterized their relationships. We quantified novelty in character co-occurrences and the valence of relationships and estimated event memorability. Within the hippocampus, the novelty subspaces encoding each type exhibited partial overlap, and these overlapping novelty subspaces aligned with the subspace involved in memorability. Notably, following event boundaries, hippocampal states within these subspaces aligned inversely along a shared coding axis, predicting subsequent recall performance. This novelty-memorability alignment was selectively observed during encoding but not during retrieval. Our findings offer novel insights into how the hippocampus dynamically coordinates computations underlying memory encoding and retrieval at the population level to transform ongoing experiences into enduring memories.

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Prior expectation enhances sensorimotor behavior by modulating population tuning and subspace activity in sensory cortex

Cited by 5 publications

References 80 publications

Localized and global representation of prior value, sensory evidence, and choice in male mouse cerebral cortex

Localized and global representation of prior value, sensory evidence, and choice in male mouse cerebral cortex

How preferences enslave attention: calling into question the endogenous/exogenous distinction from an active inference perspective

Coordinated Computations for Naturalistic Memory Encoding and Retrieval in Hippocampal Neural Subspaces

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