Prior exposure to organophosphorus and organochlorine pesticides increases the allergic potential of environmental chemical allergens in a local lymph node assay

Fukuyama, Tomoki; Kosaka, Toshio; Tajima, Yukari; Ueda, Hideo; Hayashi, Kôichi; Shutoh, Yasufumi; Harada, Takanori

doi:10.1016/j.toxlet.2010.09.018

Cited by 27 publications

(18 citation statements)

References 53 publications

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“…Conversely, organophosphates may also increase proinflammatory cytokines (IFNg, TNFa, IL-1b) in the airways via stimulation of inflammatory cells that may contribute to airway hyper-reactivity by decreasing M2 receptor expression and function in nonsensitized individuals [41 ]. Recently, it has been reported that prior exposure to organophosphates and organochlorine pesticides increases the allergic potential of environmental chemical allergens in BALB/c mice by inducing an increased surface antigen expression of T cells [44 ].…”

Section: M2 Receptor Dysfunctionmentioning

confidence: 99%

Pesticides and asthma

Hernández

Parrón²,

Alarcón³

2011

Current Opinion in Allergy &Amp; Clinical Immunology

138

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Many pesticides are sensitizers or irritants capable of directly damaging the bronchial mucosa, thus making the airway very sensitive to allergens or other stimuli. However, most pesticides are weakly immunogenic so that their potential to sensitize airways in exposed populations is limited. Pesticides may increase the risk of developing asthma, exacerbate a previous asthmatic condition or even trigger asthma attacks by increasing bronchial hyper-responsiveness.

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Section: M2 Receptor Dysfunctionmentioning

confidence: 99%

Pesticides and asthma

Hernández

Parrón²,

Alarcón³

2011

Current Opinion in Allergy &Amp; Clinical Immunology

138

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“…PROSKOCIL et al [16] have reported a lower potentiated vagally induced bronchoconstriction threshold in allergen sensitised guinea pigs, and increased production of proinflammatory cytokines in guinea pigs induced by organophosphate insecticides [17]. FUKUYAMA et al [18] have also demonstrated, in BALBc mice, that the allergic potential of environmental chemical allergens could be increased by prior exposure to organophosphate and organochlorine insecticides. According to the authors, this can be explained by an increase of T-cell surface antigen expression.…”

Section: Introductionmentioning

confidence: 99%

Environmental exposure to pesticides and respiratory health

et al. 2015

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Respiratory effects of environmental exposure to pesticides are debated. Here we aimed to review epidemiological studies published up until 2013, using the PubMed database. 20 studies dealing with respiratory health and non-occupational pesticide exposure were identified, 14 carried out on children and six on adults.In four out of nine studies in children with biological measurements, mothers' dichlorodiphenyldichloroethylene (DDE) blood levels during pregnancy were associated with asthma and wheezing in young children. An association was also found between permethrin in indoor air during pregnancy and wheezing in children. A significant association between asthma and DDE measured in children's blood (aged 7-10 years) was observed in one study. However, in three studies, no association was found between asthma or respiratory infections in children and pesticide levels in breast milk and/or infant blood. Lastly, in three out of four studies where post-natal pesticide exposure of children was assessed by parental questionnaire an association with respiratory symptoms was found. Results of the fewer studies on pesticide environmental exposure and respiratory health of adults were much less conclusive: indeed, the associations observed were weak and often not significant.In conclusion, further studies are needed to confirm whether there is a respiratory risk associated with environmental exposure to pesticides. @ERSpublications Occupational pesticide exposure increases respiratory health risk but data are unclear for environmental exposures http://ow.ly/PSGvz

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“…We also previously showed that exposure to MXC, PARA, or PBO results in increased thymocyte apoptosis, markedly inhibits and SRBC-specific IgM production 18,19 . We selected the doses of MXC (100 mg/kg day), PARA (1.0 mg/kg day) and PBO (100 mg/kg day) based on the results from acute oral LD50 doses (2900 mg/kg, 5 mg/kg and 2600 mg/kg, Designations of treatments are as in Figure 2.…”

Section: Discussionmentioning

confidence: 73%

Effects of prior oral exposure to combinations of environmental immunosuppressive agents on ovalbumin allergen-induced allergic airway inflammation in Balb/c mice

Fukuyama

Nishino

Kosaka

et al. 2014

Immunopharmacology and Immunotoxicology

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Humans are exposed daily to multiple environmental chemicals in the atmosphere, in food, and in commercial products. Therefore, hazard identification and risk management must account for exposure to chemical mixtures. The objective of the study reported here was to investigate the effects of combinations of three well-known environmental immunotoxic chemicals - methoxychlor (MXC), an organochlorine compound; parathion (PARA), an organophosphate compound; and piperonyl butoxide (PBO), an agricultural insecticide synergist - by using a mouse model of ovalbumin (OVA)-induced allergic airway inflammation. Four-week-old Balb/c mice were exposed orally to either one or two of the environmental immunotoxic chemicals for five consecutive days, prior to intraperitoneal sensitization with OVA and an inhalation challenge. We assessed IgE levels in serum, B-cell counts, and cytokine production in hilar lymph nodes, and differential cell counts and levels of related chemokines in bronchoalveolar lavage fluid (BALF). Mice treated with MXC + PARA or PBO + MXC showed marked increases in serum IgE, IgE-positive B-cells and cytokines in lymph nodes, and differential cell counts and related chemokines in BALF compared with mice that received the vehicle control or the corresponding individual test substances. These results suggest that simultaneous exposure to multiple environmental chemicals aggravates allergic airway inflammation more than exposure to individual chemicals. It is expected that the results of this study will help others in their evaluation of immunotoxic combinational effects when conducting assessments of the safety of environmental/occupational chemicals.

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Prior exposure to organophosphorus and organochlorine pesticides increases the allergic potential of environmental chemical allergens in a local lymph node assay

Cited by 27 publications

References 53 publications

Pesticides and asthma

Pesticides and asthma

Environmental exposure to pesticides and respiratory health

Effects of prior oral exposure to combinations of environmental immunosuppressive agents on ovalbumin allergen-induced allergic airway inflammation in Balb/c mice

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