Prior History of Traumatic Brain Injury Among Persons in the Traumatic Brain Injury Model Systems National Database

Corrigan, John; Bogner, Jennifer; Mellick, Dave; Bushnik, Tamara; Dams-O’Connor, Kristen; Hammond, Flora M.; Hart, Tessa; Kolakowsky-Hayner, Stephanie A.

doi:10.1016/j.apmr.2013.05.018

Cited by 77 publications

(71 citation statements)

References 26 publications

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“…These findings are consistent with a recent article that evaluated rates of previous TBI among individuals with moderate to severe TBI in the National Institutes of Disability and Rehabilitation Research-funded TBI Model Systems: Those with previous injuries had less-severe ''index'' TBIs (the injury that led to their inclusion in the Model Systems research database) and had higher levels of functioning at admission and discharge from inpatient rehabilitation, compared to those without a previous injury. 36 The investigators speculated that high rates of preindex injury emotional and behavioral problems (also consistent with the findings of the current study) may result in those with previous TBI appearing more clinically complicated, and with a greater need for intensive rehabilitation care, despite the TBI itself being less severe. It is also possible that having sustained a previous TBI resulted in greater awareness and care seeking on the part of the injured individual, making those with a previous TBI more likely to recognize the injury present to the ED and possibly even request a CT scan.…”

Section: Dams-o'connor Et Alsupporting

confidence: 70%

“…However, support for a causative relationship comes from a recent study that found a direct relationship between severity of previous TBIs and levels of both anxiety and depression after the index (most recent) injury. 36 Individuals with and without previous TBI reported similar rates of unemployment at the 3-month follow-up; but, at 6 months postinjury, most of the participants with no previous TBI had returned to work, whereas many of those with a previous TBI remained unemployed. These analyses excluded individuals who had been unemployed at the time of the current injury, so this finding suggests that recurrent TBI had a cumulative detrimental effect on these individuals.…”

Section: Dams-o'connor Et Almentioning

confidence: 97%

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The Impact of Previous Traumatic Brain Injury on Health and Functioning: A TRACK-TBI Study

Dams-O'ConnorKristen

SpielmanLisa

SinghAyushi

et al. 2013

Journal of Neurotrauma

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122

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The idea that multiple traumatic brain injury (TBI) can have a cumulative detrimental effect on functioning is widely accepted. Most research supporting this idea comes from athlete samples, and it is not known whether remote history of previous TBI affects functioning after subsequent TBI in community-based samples. This study investigates whether a previous history of TBI with loss of consciousness (LOC) is associated with worse health and functioning in a sample of individuals who require emergency department care for current TBI. Twenty-three percent of the 586 individuals with current TBI in the Transforming Research and Clinical Knowledge in Traumatic Brain Injury study reported having sustained a previous TBI with LOC. Individuals with previous TBI were more likely to be unemployed (v 2 = 17.86; p = 0.000), report a variety of chronic medical and psychiatric conditions (4.75 £ v 2 ‡ 24.16; p < 0.05), and report substance use (16.35 £ v 2 ‡ 27.57; p < 0.01) before the acute injury, compared to those with no previous TBI history. Those with a previous TBI had less-severe acute injuries, but experienced worse outcomes at 6-month follow-up. Results of a series of regression analyses controlling for demographics and acute injury severity indicated that individuals with previous TBI reported more mood symptoms, more postconcussive symptoms, lower life satisfaction, and had slower processing speed and poorer verbal learning, compared to those with no previous TBI history. These findings suggest that history of TBI with LOC may have important implications for health and psychological functioning after TBI in community-based samples.

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Section: Dams-o'connor Et Alsupporting

confidence: 70%

Section: Dams-o'connor Et Almentioning

confidence: 97%

The Impact of Previous Traumatic Brain Injury on Health and Functioning: A TRACK-TBI Study

Dams-O'ConnorKristen

SpielmanLisa

SinghAyushi

et al. 2013

Journal of Neurotrauma

Self Cite

122

View full text Add to dashboard Cite

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“…Children who suffer TBIs early in life are at a much greater risk for alcohol abuse disorders later in life and this is of particular importance in light of the data linking post-TBI drinking to poorer long-term outcomes. [4][5][6][7] Alcohol use and misuse are closely and bi-directionally linked to TBI; by some estimates, intoxication is the direct or indirect cause of one-third to one-half of all TBI cases. 8,9 There also is mounting clinical and experimental evidence that TBI increases problem alcohol intake.…”

mentioning

confidence: 99%

“…[9][10][11][12] Problem drinking also greatly increases the chances for additional TBI later in life, which can produce much greater impairments in previously injured patients. 4 Children who suffer TBI are less likely to complete their education, find employment, and marry, and are more likely to suffer from poor health, neurological symptoms, and psychiatric ailments, which interact with, or are exacerbated by, alcohol misuse. 4,13,14 Therefore targeting the substance abuse issues in TBI patients can have significant and long-term health benefits.…”

mentioning

confidence: 99%

Juvenile Traumatic Brain Injury Increases Alcohol Consumption and Reward in Female Mice

Weil

Karelina

Gaier

et al. 2016

Journal of Neurotrauma

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Traumatic brain injury (TBI) is closely and bi-directionally linked with alcohol use, as by some estimates intoxication is the direct or indirect cause of one-third to one-half of all TBI cases. Alcohol use following injury can reduce the efficacy of rehabilitation and increase the chances for additional injury. Finally, TBI itself may be a risk factor for the development of alcohol use disorders. Children who suffer TBIs have poorer life outcomes and more risk of substance abuse. We used a standardized closed-head injury to model mild traumatic brain injuries. We found that mice injured as juveniles but not during adulthood exhibited much greater alcohol self-administration in adulthood. Further, this phenomenon was limited to female mice. Using behavioral testing, including conditioned place preference assays, we showed that early injuries increase the rewarding properties of alcohol. Environmental enrichment administered after injury reduced axonal degeneration and prevented the increase in drinking behavior. Additionally, brain-derived neurotrophic factor gene expression, which was reduced by TBI, was normalized by environmental enrichment. Together, these results suggest a novel model of alterations in reward circuitry following trauma during development.

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“…Corrigan in 2013 [22] studied population up to 20 years after TBI in a retrospective analysis and observed that the proportion of substance abuse including alcohol was higher in patients who had experienced TBI before the age of 16 years. Ilie [23] compared students of 9th to 12th grade and observed that the adjusted odds of past year drinking and binge drinking increased by a factor of 2 for students with a history of TBI compared to the non-injured students.…”

Section: Comparison Of Alcohol Use Across Different Age Groups Affectmentioning

confidence: 99%

Changes in Alcohol-Related Behavior Following an Incident of Traumatic Brain Injury

Shiwalkar¹,

Gregor²,

Fu³

et al. 2017

J Trauma Treat

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Pre-existing alcohol related complications are a common occurrence amongst individuals admitted for Traumatic Brain Injury (TBI) and is estimated to be about 44% to 66% in TBI patients. In fact, alcohol intoxication is a major cause of TBI. The contribution of alcohol abuse as a cause of TBI and its influence over the pathophysiology of TBI is well studied and well known. However, the influence of TBI on alcohol consumption is still in its preliminary stages. The underlying reasons for it may be the complex interaction between the pathological changes induced by TBI itself and changes in environmental factors following an episode of TBI. The resulting alteration in alcohol-related behaviors post-TBI can affect cognitive and neurological functions and thus can influence the overall recovery of the patient.Hence, understanding changes in alcohol behavior after TBI, with respect to the timing and causes responsible for the change, is important from the perspective of long-term outcome in these patients. In this review article, we discuss a number of studies to determine changes in alcohol drinking behavior following TBI and summarize the findings with respect to the timing of significant change in behavior, as well as the factors influencing this change. Overall it can provide an important piece of information regarding the preventive measures in a major subset of the population at risk of alcohol-use disorders and utilizing them at a time when the prevention can have a maximal impact.

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Prior History of Traumatic Brain Injury Among Persons in the Traumatic Brain Injury Model Systems National Database

Cited by 77 publications

References 26 publications

The Impact of Previous Traumatic Brain Injury on Health and Functioning: A TRACK-TBI Study

The Impact of Previous Traumatic Brain Injury on Health and Functioning: A TRACK-TBI Study

Juvenile Traumatic Brain Injury Increases Alcohol Consumption and Reward in Female Mice

Changes in Alcohol-Related Behavior Following an Incident of Traumatic Brain Injury

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