“…In contrast to MEPs, which are potentially affected by a combination of cortical, subcortical and spinal mechanisms (Kiers et al, 1993), the TMS-evoked N100 directly assesses cortical responses to TMS without influences of spinal inhibitory mechanisms (Nikulin et al, 2003;Bender et al, 2005a;Ilmoniemi and Kicic, 2010). In healthy subjects, the TMS-evoked N100 component decreases during motor cortex disinhibition related to movement execution (Nikulin et al, 2003) and motor response preparation (Bender et al, 2005a) and increases during response inhibition (Bonnard et al, 2009). Therefore, the TMS-evoked N100 is considered to be a marker of motor cortex inhibition influenced by cortico-striato-thalamo-cortical loops (Bender et al, 2005a).…”