Prior lung disease and lung cancer risk in an occupational-based cohort in Yunnan, China

Is Previous Respiratory Disease a Risk Factor for Lung Cancer?

“…A meta-analysis found that tuberculosis was associated with adenocarcinoma lung cancer, but not squamous or small cell carcinoma (33). Findings from this study, of overall no association between tuberculosis and lung cancer, are consistent with a previous investigation of tuberculosis which accounted for co-occurring pulmonary diseases, such as chronic bronchitis and asthma (34). However, the number of case subjects with tuberculosis in this consortium was small and thus results should be interpreted with caution.…”

“…A Hong Kong longitudinal study that grouped COPD and asthma observed no association with lung cancer mortality in female never-smokers (35). A Chinese occupational cohort study examining chronic bronchitis, asthma, and tuberculosis found that only prior chronic bronchitis was associated with an increased lung cancer risk, with an adjusted HR of 1.50 (95% CI, 1.24-1.81), after including all respiratory diseases in the same model (34). A general practice study in the United Kingdom found no independent association between asthma and lung cancer after excluding all patients with a diagnoses of COPD (30).…”

Associations between history of chronic lung disease and non–small cell lung carcinoma in Maryland: variations by sex and race

“…Association between asthma and lung cancer risk was reported by some investigators [23,32,33], but not by others [19,21,30,34,35] who reported associations with chronic bronchitis [34] and/or emphysema [21,30,35]. We defined chronic lung disease as having had a diagnosis of COPD, chronic bronchitis, emphysema, or asthma, all of which result in chronic inflammation of the respiratory system, although COPD and asthma are clinically different entities.…”

Prevention and management of lung cancer in China

“…Another study in Yunnan indicated that the high incidence of lung cancer was associated with a history of chronic bronchitis, especially in patients with squamous cell carcinoma (corrected hazard ratio, 1.57; 95% confidence interval, 1.19‐2.09). Similarly, asthma was correlated with small cell carcinoma (corrected hazard ratio, 2.56; 95% confidence interval, 1.38‐4.75) …”