Perinatal near miss covers the maternal and neonatal morbidity that refers to two targeted group of mother and baby. Maternal and perinatal mortality are two health indicators that showed very wide gaps of achievement by types of country based on income according to MDG achievement in 2015. The risk of a woman in a developing country dying from a maternal-related cause during her lifetime is much higher compared to a woman living in a developed country. Even though pattern of mortality shows declining trend in many countries, the MDG achievement has trigger more efforts to be geared and aligned. Researchers focus in assessing factors and determinant of maternal and perinatal mortality has shifted into severe morbidity cases or near miss cases. Many evaluation of obstetric care management based on the three delay model enable providers to identify points for improvement and has been mushrooming providing evidence based in scientific literature. However, where we need to focus for intervention and what kind of approaches is suitable is hardly seen published for our reference. Promoting wellbeing and ensure health are elements focussed in SDG provides ways in hindering health trajectory like perinatal near miss. However, the conceptualize approach needs to be narrated to the root of the problems. Evaluating evidence based medicine and scientific models help in generating solution on the root cause problem solving. Syndemic approach in designing preventive public health program targeting improving maternal and perinatal health is complex. It must involve pertinent component related to understanding on health seeking behaviour pattern, the monitoring and evaluation program based on log frame matrix analysis and understanding the dynamic of problem origin using three delay models.