2019
DOI: 10.1186/s12920-019-0492-9
|View full text |Cite
|
Sign up to set email alerts
|

Prioritization of genes involved in endothelial cell apoptosis by their implication in lymphedema using an analysis of associative gene networks with ANDSystem

Abstract: BackgroundCurrently, more than 150 million people worldwide suffer from lymphedema. It is a chronic progressive disease characterized by high-protein edema of various parts of the body due to defects in lymphatic drainage. Molecular-genetic mechanisms of the disease are still poorly understood. Beginning of a clinical manifestation of primary lymphedema in middle age and the development of secondary lymphedema after treatment of breast cancer can be genetically determined. Disruption of endothelial cell apopto… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
18
0

Year Published

2019
2019
2023
2023

Publication Types

Select...
7
1

Relationship

2
6

Authors

Journals

citations
Cited by 26 publications
(18 citation statements)
references
References 151 publications
(173 reference statements)
0
18
0
Order By: Relevance
“…It utilizes text mining, an automatic knowledge extraction from the texts of scientific publications. Previously, the ANDSystem was used to identify candidate genes associated with comorbidity of asthma and tuberculosis [ 119 ], preeclampsia, diabetes and obesity [ 120 ], primary open-angle glaucoma [ 121 ], asthma and hypertension [ 122 ], and lymphedema [ 123 ].…”
Section: Methodsmentioning
confidence: 99%
“…It utilizes text mining, an automatic knowledge extraction from the texts of scientific publications. Previously, the ANDSystem was used to identify candidate genes associated with comorbidity of asthma and tuberculosis [ 119 ], preeclampsia, diabetes and obesity [ 120 ], primary open-angle glaucoma [ 121 ], asthma and hypertension [ 122 ], and lymphedema [ 123 ].…”
Section: Methodsmentioning
confidence: 99%
“…The ANDSystem tool [49][50][51][52], previously developed by us, is another instance of systems that carry out a full cycle of engineering and management of knowledge. The ANDSystem tool is based on unique, specialized ontology [50], which, in many respects, outperforms the existing analogues by the description of a subject area.…”
Section: Introductionmentioning
confidence: 99%
“…What is evidently a critical situation is that these inflammatory proteins, in particular, the CCL2 and IL-6 are brought about by the actual cancer treatments themselves (e.g., radiotherapy (16) chemotherapy (8), which in turn are then associated with tumor recurrence (17) and chemo-resistance (18,19), Inflammatory events in general, whether it be from other parts of the body such as the liver (9,20) adipose tissue in obesity or arising from viral origin tend to elevate TNF-a, IL -6 and CCL2 then becoming risk factors for the development of diverse cancers (21) aggressive tumors with advanced stage tumor grade and greater rates of mortality (22,23). Meanwhile, it is believed that drugs or natural compounds that can attenuate CCL2 and IL-6 would slow the aggressive nature of advanced cancers (24)(25)(26) to the inclusion of triple negative breast cancer (TNBC) and hormone positive breast cancers (27,28). It is believed that utilizing synthetic or natural small molecules as CCR2 inhibitors (CCR2i) can increase overall survival odds (29,30).…”
Section: Introductionmentioning
confidence: 99%