Prioritization of mixtures of neurotoxic chemicals for biomonitoring using high-throughput toxicokinetics and mixture toxicity modeling

Recovery of 400 Chemicals with Three Extraction Methods for Low Volumes of Human Plasma Quantified by Instrumental Analysis and In Vitro Bioassays

“…There was an initial mix (marked in Table S2–1) that consisted of compounds mainly relevant in environmental screening. This mix was later on extended to chemicals of concern (like perfluorinated compounds) but also compounds more likely to be present in humans by being in consumer products or pharmaceuticals or prioritized for end points like neurotoxicity . The pharmaceuticals were mainly included due to their potential of artifacts in bioassays by having very specific modes of action.…”

“…This mix was later on extended to chemicals of concern (like perfluorinated compounds) but also compounds more likely to be present in humans by being in consumer products or pharmaceuticals or prioritized for end points like neurotoxicity. 36 The pharmaceuticals were mainly included due to their potential of artifacts in bioassays by having very specific modes of action. The mix was prepared without testing if compounds are stable, too volatile, behaved robust, or are sensitive in detection in this large composition.…”

Toxicological Study of Human Exposure to Mixtures of Chemicals: Challenges and Approaches

“…Then identified chemicals with significant contributions to mixture effects for future studies. 37 Public health resources such as the National Health and Nutrition Examination Survey (NHANES) can also identify chemicals relevant to specific diseases (Figure 2A). However, NHANES data typically deliver weaker causal relationship due to their cross-sectional design.…”

“…The incorporation of baseline toxicity in mixture simulations was found to yield a more realistic assessment of overall mixture effects. 37 One recent research has identified and prioritized neurotoxicants and potential new compounds, suggesting their consideration in future biomonitoring and neurotoxicity screening studies. 37 Emerging approaches, including multiomics and chemical proteomics, integrate with computational toxicology to explore mixture toxicity mechanisms comprehensively.…”

“…37 One recent research has identified and prioritized neurotoxicants and potential new compounds, suggesting their consideration in future biomonitoring and neurotoxicity screening studies. 37 Emerging approaches, including multiomics and chemical proteomics, integrate with computational toxicology to explore mixture toxicity mechanisms comprehensively. This integration enhances our understanding of "multiple exposure-multiple targets" and aids in predicting chemical contributions, thus enabling more precise mixture toxicity assessments.…”