Prioritization of NTP reproductive toxicants for field studies

Moorman, William J.; Ahlers, Heinz W.; Chapin, Robert E.; Daston, George P.; Foster, Paul M.D.; Kavlock, Robert J.; Morawetz, John; Schnorr, Teresa M.; Schrader, Steven M.

doi:10.1016/s0890-6238(00)00089-7

Cited by 57 publications

(26 citation statements)

References 7 publications

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“…Team members have suggested concepts for several grant announcements with other federal agencies for human occupational reproductive health studies, participated in the prioritization of reproductive toxicants (Moorman et al, 2000), and initiated a Hazardous Drug Working Group to improve instructions for use of antineoplastic agents in the hospital and for home health care. Results from these efforts will help researchers design epidemiologic studies that have the best prospects for interpretable results.…”

Section: Discussionmentioning

confidence: 99%

Occupational exposures and reproductive health: 2003 Teratology Society Meeting Symposium summary

Grajewski

Coble

Frazier

et al. 2005

Birth Defects Research Pt B

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Assuring reproductive health in the workplace challenges researchers, occupational safety and health practitioners, and clinicians. Most chemicals in the workplace have not been evaluated for reproductive toxicity. Although occupational exposure limits are established to protect 'nearly all' workers, there is little research that characterizes reproductive hazards. For researchers, improvements in epidemiologic design and exposure assessment methods are needed to conduct adequate reproductive studies. Occupational safety and health programs' qualitative and quantitative evaluations of the workplace for reproductive hazards may differ from standardized approaches used for other occupational hazards in that estimates of exposure intensity must be considered in the context of the time-dependent windows of reproductive susceptibility. Clinicians and counselors should place the risk estimate into context by emphasizing the limitations of the available knowledge and the qualitative nature of the exposure estimates, as well as what is known about other non-occupational risk factors for adverse outcomes. This will allow informed decision-making about the need for added protections or alternative duty assignment when a hazard cannot be eliminated. These policies should preserve a worker's income, benefits, and seniority. Applying hazard control technologies and hazard communication training can minimize a worker's risk. Chemical reproductive hazard training is required for workers by the Occupational Safety and Health Administration's Hazard Communication Standard. The National Institute for Occupational Safety and Health (NIOSH) has formed a National Occupational Research Agenda Team to promote communication and partnering among reproductive toxicologists, clinicians and epidemiologists, to improve reproductive hazard exposure assessment and management, and to encourage needed research.

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Section: Discussionmentioning

confidence: 99%

Occupational exposures and reproductive health: 2003 Teratology Society Meeting Symposium summary

Grajewski

Coble

Frazier

et al. 2005

Birth Defects Research Pt B

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“…Because the interpretation of studies of model species is often not straightforward and because field studies are labor and resource intensive, a systematic approach is needed to select and prioritize chemicals for epidemiologic studies. Moorman et al (2000) recently proposed a process for selecting chemicals for human field studies. In this process, information gained from model species testing conducted by the National Toxicology Program (NTP) was reviewed for significant adverse reproductive effects and potency of the toxicants.…”

Section: Identifying Hazardsmentioning

confidence: 99%

An occupational reproductive research agenda for the third millennium.

Lawson

Schnorr

Daston

et al. 2003

Environ Health Perspect

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There is a significant public health concern about the potential effects of occupational exposure to toxic substances on reproductive outcomes. Several toxicants with reported reproductive and developmental effects are still in regular commercial or therapeutic use and thus present potential exposure to workers. Examples of these include heavy metals, organic solvents, pesticides and herbicides, and sterilants, anesthetic gases, and anticancer drugs used in health care. Many other substances are suspected of producing reproductive or developmental toxicity but lack sufficient data. Progress has been limited in identifying hazards and quantifying their potencies and in separating the contribution of these hazards from other etiologic factors. Identifying the causative agents, mechanisms by which they act, and any potential target populations, present the opportunity to intervene and protect the reproductive health of workers. The pace of laboratory studies to identify hazards and to underpin the biologic plausibility of effects in humans has not matched the pace at which new chemicals are introduced into commerce. Though many research challenges exist today, recent technologic and methodologic advances have been made that allow researchers to overcome some of these obstacles. The objective of this article is to recommend future directions in occupational reproductive health research. By bridging interdisciplinary gaps, the scientific community can work together to improve health and reduce adverse outcomes.

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“…N,N-dimethylformamide (DMF), N-methyl-2-pyrrolidinone (NMP), or hexamethylphosphorus triamide (HMPT), as solvents. However, unsatisfactory efficacy [1-6], troublesome work up [21], and hazards to reproductive health [22] associated with these solvents do not meet the demands of eco-awareness and cost-consciousness. Also, in the presence of MeONa, decomposition of the amides unavoidably complicates the reaction work up.…”

Section: Introductionmentioning

confidence: 99%

A ligand-free, powerful, and practical method for methoxylation of unactivated aryl bromides by use of the CuCl/HCOOMe/MeONa/MeOH system

Guo

Chen

et al. 2015

Res Chem Intermed

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A ligand-free, powerful, and practical method for mono and polymethoxylation of unactivated aryl bromides has been developed; CuCl was used as catalyst, HCOOMe as cocatalyst, and methanolic MeONa as both nucleophile and solvent. This eco-friendly procedure is characterized by operational simplicity, inexpensive substrates (unactivated mono to polybromoarenes), full conversion, and direct recovery of pure MeOH.

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Prioritization of NTP reproductive toxicants for field studies

Cited by 57 publications

References 7 publications

Occupational exposures and reproductive health: 2003 Teratology Society Meeting Symposium summary

Occupational exposures and reproductive health: 2003 Teratology Society Meeting Symposium summary

An occupational reproductive research agenda for the third millennium.

A ligand-free, powerful, and practical method for methoxylation of unactivated aryl bromides by use of the CuCl/HCOOMe/MeONa/MeOH system

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