Prioritized brain selenium retention and selenoprotein expression: Nutritional insights into Parkinson’s disease

Zhang, Xiong; Liu, Rong-Pei; Cheng, Wen‐Hsing; Zhu, Jian-Hong

doi:10.1016/j.mad.2019.04.004

Cited by 38 publications

(27 citation statements)

References 93 publications

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“…SELENOT expression is significantly increased in the peripheral blood mononuclear cells and brain striatal tissue of PD patients. Both silencing and overexpression of SELENOT influence oxidative stress and apoptosis in dopaminergic neurons (Boukhzar et al, 2016;Shao et al, 2019;Zhang et al, 2019). Dopaminergic neurons are also closely associated with AD pathology, and several alterations in the dopaminergic system have been reported in AD patients (Burns et al, 2005;Rossato et al, 2009).…”

Section: Selenok Selenot Selenos and Selenommentioning

confidence: 99%

Roles of Selenoproteins in Brain Function and the Potential Mechanism of Selenium in Alzheimer’s Disease

Zhang

Song

2021

Front. Neurosci.

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Selenium (Se) and its compounds have been reported to have great potential in the prevention and treatment of Alzheimer’s disease (AD). However, little is known about the functional mechanism of Se in these processes, limiting its further clinical application. Se exerts its biological functions mainly through selenoproteins, which play vital roles in maintaining optimal brain function. Therefore, selenoproteins, especially brain function-associated selenoproteins, may be involved in the pathogenesis of AD. Here, we analyze the expression and distribution of 25 selenoproteins in the brain and summarize the relationships between selenoproteins and brain function by reviewing recent literature and information contained in relevant databases to identify selenoproteins (GPX4, SELENOP, SELENOK, SELENOT, GPX1, SELENOM, SELENOS, and SELENOW) that are highly expressed specifically in AD-related brain regions and closely associated with brain function. Finally, the potential functions of these selenoproteins in AD are discussed, for example, the function of GPX4 in ferroptosis and the effects of the endoplasmic reticulum (ER)-resident protein SELENOK on Ca2+ homeostasis and receptor-mediated synaptic functions. This review discusses selenoproteins that are closely associated with brain function and the relevant pathways of their involvement in AD pathology to provide new directions for research on the mechanism of Se in AD.

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Section: Selenok Selenot Selenos and Selenommentioning

confidence: 99%

Roles of Selenoproteins in Brain Function and the Potential Mechanism of Selenium in Alzheimer’s Disease

Zhang

Song

2021

Front. Neurosci.

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“…[ 64 ] In addition, several selenoproteins were shown to protect dopaminergic neurons, reinforcing the beneficial property of Se against Parkinson's disease. [ 67,68 ] Se levels have also been correlated with mood alterations, depression, and aggressive behavior. [ 9 ] However, since brain Se levels are rarely low, and excessive Se levels may also be prejudicial, its application in neuronal disorders may only be advantageous for patients with severe Se deficiency and/or with mutations in genes related with Se delivery or selenoproteins production.…”

Section: Selenium Compounds and Their Physiological Effectsmentioning

confidence: 99%

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Ferro

Florindo

Santos

2021

Adv Healthcare Materials

254

146

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Selenium (Se) is an essential element to human health that can be obtained in nature through several sources. In the human body, it is incorporated into selenocysteine, an amino acid used to synthesize several selenoproteins, which have an active center usually dependent on the presence of Se. Although Se shows several beneficial properties in human health, it has also a narrow therapeutic window, and therefore the excessive intake of inorganic and organic Se‐based compounds often leads to toxicity. Nanoparticles based on Se (SeNPs) are less toxic than inorganic and organic Se. They are both biocompatible and capable of effectively delivering combinations of payloads to specific cells following their functionalization with active targeting ligands. Herein, the main origin of Se intake, its role on the human body, and its primary biomedical applications are revised. Particular focus will be given to the main therapeutic targets that are explored for SeNPs in cancer therapies, discussing the different functionalization methodologies used to improve SeNPs stability, while enabling the extensive delivery of drug‐loaded SeNP to tumor sites, thus avoiding off‐target effects.

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“…The brain is particularly dependent on selenium due to high rates of oxygen consumption and heightened susceptibility to oxidative stress (Steinbrenner and Sies, 2013). Insufficient selenium supply and lack of selenoprotein function have been linked to multiple brain disorders, including neurodegenerative diseases, which have been thoroughly discussed in previous reviews (Pillai et al, 2014;Solovyev, 2015;Varikasuvu et al, 2019;Zhang et al, 2019). Conversely, selenium has been suggested as a potential therapeutic agent in the treatment of Alzheimer's disease (Solovyev et al, 2018), multiple sclerosis (de Toledo et al, 2020), and stroke (Alim et al, 2019).…”

Section: Selenium and Selenoproteins In Brain Healthmentioning

confidence: 99%

Stress and the Brain: An Emerging Role for Selenium

2021

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The stress response is an important tool in an organism’s ability to properly respond to adverse environmental conditions in order to survive. Intense acute or chronic elevation of glucocorticoids, a class of stress hormone, can have deleterious neurological effects, however, including memory impairments and emotional disturbances. In recent years, the protective role of the antioxidant micronutrient selenium against the negative impact of externally applied stress has begun to come to light. In this review, we will discuss the effects of stress on the brain, with a focus on glucocorticoid action in the hippocampus and cerebral cortex, and emerging evidence of an ability of selenium to normalize neurological function in the context of various stress and glucocorticoid exposure paradigms in rodent models.

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Prioritized brain selenium retention and selenoprotein expression: Nutritional insights into Parkinson’s disease

Cited by 38 publications

References 93 publications

Roles of Selenoproteins in Brain Function and the Potential Mechanism of Selenium in Alzheimer’s Disease

Roles of Selenoproteins in Brain Function and the Potential Mechanism of Selenium in Alzheimer’s Disease

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Stress and the Brain: An Emerging Role for Selenium

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