Prise en charge diagnostique et thérapeutique actuelle des accidents vasculaires cérébraux post-varicelleux chez l’enfant : revue de la littérature

Monteventi, Olivia; Chabrier, Stéphane; Fluss, Joël Victor

doi:10.1016/j.arcped.2013.05.013

Cited by 11 publications

(4 citation statements)

References 45 publications

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“…The role of targeted antiviral and/or anti-inflammatory steroid therapies in post-VZV AIS is still debated. Indeed, there are only few papers reporting the outcome of patients treated with antiviral and steroid, and prospective randomized studies are still missing (4,34,(38)(39)(40)(41)(42)(43). Based upon Level 2 class of evidence (systemic review of cohort studies and individual cohort studies) (6), antiviral therapy with iv acyclovir is proposed in VZV-angiopathy for 14-21 days, which may be prolonged in immunosuppressed/immunocompromised patients in whom recurrence is common (7).…”

Section: Discussionmentioning

confidence: 99%

An atypical case of post-varicella stroke in a child presenting with hemichorea followed by late-onset inflammatory focal cerebral arteriopathy

Bertamino

Signa

Vagelli

et al. 2021

Quant Imaging Med Surg

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Section: Discussionmentioning

confidence: 99%

An atypical case of post-varicella stroke in a child presenting with hemichorea followed by late-onset inflammatory focal cerebral arteriopathy

Bertamino

Signa

Vagelli

et al. 2021

Quant Imaging Med Surg

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“…as risk factors for FCA-i and AIS. [6][7][8][9][10][11] The term focal cerebral arteriopathy (FCA), which included unifocal or multifocal, unilateral or bilateral stenosis of variable etiologies (e.g. dissection or moyamoya disease and syndrome) was later defined, and TCA was seen as a subgroup of FCA 12,13 .…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Type Focal Cerebral Arteriopathy of the Posterior Circulation in Children: a comparative cohort study

Slavova

Muenger

Sánchez-Albisua

et al. 2023

Preprint

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Background<break>Inflammatory type Focal Cerebral Arteriopathy (FCA-i) in the anterior circulation (AC) is well characterized and the FCA severity score (FCASS) reflects the severity of disease. We identified cases of FCA-i in the posterior circulation (PC) and adapted the FCASS to describe these cases.<break><break>Methods<break>Patients from the Swiss NeuroPaediatric Stroke Registry (SNPSR) with ischemic stroke in the PC and AC due to FCA-i and available neuroimaging were gathered. Comparison of data regarding Pediatric National Institutes of Health Stroke Scale (pedNIHSS) score and Pediatric Stroke Outcome Measure (PSOM) and FCASS was performed. We estimated infarct size by the modified pediatric Alberta Stroke Program Early Computed Tomography Score (pedASPECTS) in children with AC stroke and the adapted Bernese posterior diffusion-weighted imaging (DWI) score in the PC.<break>Results<break>Thirty-six children with a median age of 6.3 years ([IQR 2.8,8.6; range 0.9,15.6], 21 males, 58.3%) with FCA-i were identified. The total incidence rate was 0.151/100 000/year (95%CI 0.1090.209). Seven had PC FCA-i and 5 had FCA-i in both circulations. Time to final FCASS was longer in the PC compared to AC, evolution of FCASS did not differ. Initial pedNIHSS was highest in children with FCA-i in the PC with a median of 8.0 (IQR 5.0-18.0), compared to 4.5 (IQR 2.0-8.0) in those with AC FCA-i and 6.0 (IQR 6.0-6.0) with involvement of both AC and PC. Different to the anterior cases PC infarct volume did not correlate with higher discharge, maximum or final FCASS scores (R 0.25, 0.35, 0.54). <break><break>Conclusion<break>The PC is affected in up to one third of cases of FCA-i. These cases should be included in future investigations on FCA-i. Although it did not correlate with clinical outcome in our cohort, the modified FCASS may well serve as a marker for the evolution of the arteriopathy in posterior FCA-i.

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“…2,3 Herpes simplex virus, enterovirus, mycoplasma pneumonia, or Borrelia burgdorferi infections have been reported as risk factors for FCA-i and AIS. [10][11][12][13][14][15] Based on the hypothesis of an inflammatory pathogenesis, corticosteroids are increasingly used to treat FCA-i. 16 However, there is still no clinical trial data to support this treatment.…”

mentioning

confidence: 99%

“…2,3 Herpes simplex virus, enterovirus, mycoplasma pneumonia, or Borrelia burgdorferi infections have been reported as risk factors for FCA-i and AIS. 10–15…”

mentioning

confidence: 99%

Inflammatory Type Focal Cerebral Arteriopathy of the Posterior Circulation in Children: A Comparative Cohort Study

Slavova,

Muenger,

Sanchez-Albisua

et al. 2024

Stroke

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BACKGROUND: Inflammatory type focal cerebral arteriopathy (FCA-i) in the anterior circulation (AC) is well characterized, and the focal cerebral arteriopathy severity score (FCASS) reflects the severity of the disease. We identified cases of FCA-i in the posterior circulation (PC) and adapted the FCASS to describe these cases. METHODS: In this comparative cohort study, patients from the Swiss NeuroPaediatric Stroke Registry with ischemic stroke due to FCA-i between January 2000 and December 2018 were analyzed. A comparison between PC and AC cases regarding pediatric National Institutes of Health Stroke Scale score and pediatric stroke outcome measure and FCASS was performed. We estimated infarct size by the modified pediatric Alberta Stroke Program Early Computed Tomography Score in children with AC stroke and the adapted Bernese posterior diffusion–weighted imaging score in the PC. RESULTS: Thirty-five children with a median age of 6.3 (interquartile range, 2.7–8.2 [95% CI, 0.9–15.6]; 20 male; 57.1%) years with FCA-i were identified. The total incidence rate was 0.15/100 000/year (95% CI, 0.11–0.21). Six had PC-FCA-i. Time to final FCASS was longer in the PC compared with AC; the evolution of FCASS did not differ. Initial pediatric National Institutes of Health Stroke Scale score was higher in children with FCA-i in the PC with a median of 10.0 (interquartile range, 5.75–21.0) compared with 4.5 (interquartile range, 2.0–8.0) in those with AC-FCA-i. Different from the anterior cases, PC infarct volume did not correlate with higher discharge, maximum, or final FCASS scores (Pearson correlation coefficient [r], 0.25, 0.35, and 0.54). CONCLUSIONS: FCA-i also affects the PC. These cases should be included in future investigations into FCA-i. Although it did not correlate with clinical outcomes in our cohort, the modified FCASS may well serve as a marker for the evolution of the arteriopathy in posterior FCA-i.

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Prise en charge diagnostique et thérapeutique actuelle des accidents vasculaires cérébraux post-varicelleux chez l’enfant : revue de la littérature

Cited by 11 publications

References 45 publications

An atypical case of post-varicella stroke in a child presenting with hemichorea followed by late-onset inflammatory focal cerebral arteriopathy

An atypical case of post-varicella stroke in a child presenting with hemichorea followed by late-onset inflammatory focal cerebral arteriopathy

Inflammatory Type Focal Cerebral Arteriopathy of the Posterior Circulation in Children: a comparative cohort study

Inflammatory Type Focal Cerebral Arteriopathy of the Posterior Circulation in Children: A Comparative Cohort Study

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