PRISM study: Comparison of a nystatin-neomycin-polymyxin B combination with miconazole for the empirical treatment of infectious vaginitis

Bohbot, Jean-Marc; Goubard, Agathe; Aubin, F; Mas, Y.; Coatantiec, E.; Lucas, Nicola; Verrière, François

doi:10.1016/j.medmal.2019.01.011

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…The hydrophobic C 18 and dopamine (DOPA) 31–33 were grafted onto the PSI to form adhesive nano‐aggregates. Neomycin (NEO), an antibiotic drug 34–36 was conjugated with glycine (GLY) to enable pH‐sensitive NEO release, as the wound site is generally acidic 37,38 . NEO is an aminoglycoside antibiotic widely applied in antibacterial activity 39,40 .…”

Section: Introductionmentioning

confidence: 99%

Biodegradable polyaspartamide‐g‐C₁₈/DOPA/GLY‐NEO nano‐adhesives for wound closure/healing with antimicrobial activity

Lim

Kim

2022

J Biomedical Materials Res

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This study was focused on the development of biodegradable nano‐adhesives with efficient sealing and antibiotic effects for wound healing. Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles—octadecylamine (C18) for nano‐aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection. Specifically, NEO was conjugated to PASPAM with a pH‐sensitive glycine (GLY) linker for targeted delivery on the acidic wound site. About 60% of the drug was ramteleased at pH 6.0, while about 22% was released at pH 7.4, showing the faster drug release pattern of nano‐adhesives in the acidic environment. The C18/DOPA/GLY‐NEO‐g‐PASPAM nano‐adhesives showed the bacterial viability higher than 70% at pH 7.4, but about 40% at pH 6.0. The wound breaking strength of the polymer‐treated skin was much higher than that of the bare skin. According to the in vivo wound healing test using a mouse model, C18/DOPA/GLY‐NEO‐g‐PASPAM nano‐adhesives showed much faster healing performance than sutures. From those results, C18/DOPA/GLY‐NEO‐g‐PASPAM nano‐adhesives are expected to be utilized as effective adhesives that promote the wound healing with inhibition of bacterial infection.

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Section: Introductionmentioning

confidence: 99%

Biodegradable polyaspartamide‐g‐C₁₈/DOPA/GLY‐NEO nano‐adhesives for wound closure/healing with antimicrobial activity

Lim

Kim

2022

J Biomedical Materials Res

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Mixed vaginitis. What's new? Features of the course and therapy of mixed vaginitis

Dobrokhotova¹,

Markova²

2022

Probl. reprod.

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Looking for Appropriateness in the Cure of Mixed Vaginitis: The Role of Fenticonazole as an Empiric Treatment

Tumietto

Posteraro

2019

Future Microbiol.

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Mixed vaginitis is defined as the simultaneous presence of at least two different vaginal pathogens, both contributing to an abnormal vaginal milieu leading to signs and symptoms. Pathogen coinfection occurs frequently in women with vaginitis, and both coinfection and mixed vaginitis have relevant clinical and therapeutic implications. Fenticonazole, an imidazole derivative with a broad spectrum of antimycotic and antimicrobial activity, appears at least as effective as other topical antifungals in the treatment of vulvovaginal candidiasis and can also have a major role in the treatment of mixed infections or coinfections of the lower genital tract. This paper will address the current role of topical fenticonazole as an empiric treatment of vulvovaginal infections, with a focus on the effectiveness in the treatment of mixed vaginitis and the possible implications of this.

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PRISM study: Comparison of a nystatin-neomycin-polymyxin B combination with miconazole for the empirical treatment of infectious vaginitis

Cited by 5 publications

References 17 publications

Biodegradable polyaspartamide‐g‐C₁₈/DOPA/GLY‐NEO nano‐adhesives for wound closure/healing with antimicrobial activity

Biodegradable polyaspartamide‐g‐C₁₈/DOPA/GLY‐NEO nano‐adhesives for wound closure/healing with antimicrobial activity

Mixed vaginitis. What's new? Features of the course and therapy of mixed vaginitis

Looking for Appropriateness in the Cure of Mixed Vaginitis: The Role of Fenticonazole as an Empiric Treatment

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PRISM study: Comparison of a nystatin-neomycin-polymyxin B combination with miconazole for the empirical treatment of infectious vaginitis

Cited by 5 publications

References 17 publications

Biodegradable polyaspartamide‐g‐C18/DOPA/GLY‐NEO nano‐adhesives for wound closure/healing with antimicrobial activity

Biodegradable polyaspartamide‐g‐C18/DOPA/GLY‐NEO nano‐adhesives for wound closure/healing with antimicrobial activity

Mixed vaginitis. What's new? Features of the course and therapy of mixed vaginitis

Looking for Appropriateness in the Cure of Mixed Vaginitis: The Role of Fenticonazole as an Empiric Treatment

Contact Info

Product

Resources

About

Biodegradable polyaspartamide‐g‐C₁₈/DOPA/GLY‐NEO nano‐adhesives for wound closure/healing with antimicrobial activity

Biodegradable polyaspartamide‐g‐C₁₈/DOPA/GLY‐NEO nano‐adhesives for wound closure/healing with antimicrobial activity