The popularity of global GPS location services and location-enabled personal terminal applications has contributed to the rapid growth of location-based social networks. Users can access social networks at anytime and anywhere to obtain services in the relevant location. While accessing services is convenient, there is a potential risk of leaking users’ private information. In data processing, the discovery of issues and the generation of optimal solutions constitute a symmetrical process. Therefore, this paper proposes a symmetry–trajectory differential privacy-protection mechanism based on multi-dimensional prediction (TPPM-MP). Firstly, the temporal attention mechanism is designed to extract spatiotemporal features of trajectories from different spatiotemporal dimensions and perform trajectory-sensitive prediction. Secondly, class-prevalence-based weights are assigned to sensitive regions. Finally, the privacy budget is assigned based on the sensitive weights, and noise conforming to localized differential privacy is added. Validated on real datasets, the proposed method in this paper enhanced usability by 22% and 37% on the same dataset compared with other methods mentioned, while providing equivalent privacy protection.