PRKAA1 rs13361707 C/T polymorphism confers decreased susceptibility to esophageal cancer: A case‐control study

Li, Chenglin; Zhao, Jianqiang; Zang, Bao

doi:10.1002/jcla.23406

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…We analyzed the PRKAA1 polymorphic loci rs13361707, rs3792822, and rs10074991. In our study, the variation frequency of rs13361707 in healthy subjects was 72.88%, which was similar to the 71.8% reported by previous research ( Li et al, 2020 ). Otherwise, it was different from the 80.86% reported by Yuan et al (2016) .…”

Section: Discussionsupporting

confidence: 92%

“…Previous studies have found that gene polymorphisms are closely related to drug metabolism and disease occurrence ( Wang et al, 2013 ; Mei et al, 2015 ; Guo et al, 2021 ). However, there are few studies on the correlation between AMPK gene polymorphisms and gastric cancer, rectal cancer, diabetes mellitus and Hepatitis B virus infection ( Lee et al, 2014 ; Yuan et al, 2016 ; Chen et al, 2018 ; Jiang et al, 2018 ; Li et al, 2020 ). Our previous study identified that the PRKAA2 gene polymorphism had a significant effect on PHN susceptibility ( Mei et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study

Yang

Chen

et al. 2023

Front. Mol. Neurosci.

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Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) is a pivotal regulatory protein in energy metabolism. In a pilot study, we found that AMPK-associated energy metabolism imbalance in neurons contributes to the occurrence and maintenance of neuropathic pain (NeP). This study aimed to explore the relationship between genetic polymorphisms of AMPK gene (Rs13361707, rs3792822, and rs10074991) in PRKAA1 and postherpetic neuralgia (PHN) in Chinese individuals. Hundred and thirty two patients with PHN and 118 control individuals were enrolled in this study. All blood samples were shuffled and blinded to the person performing the haplotype analysis. Rs13361707, rs3792822, and rs10074991 PRKAA1 genotypes were identified in all participants. Dominant and recessive models were used for evaluating the association between these nucleotide polymorphisms and PHN susceptibility. A haplotype analysis of PHN patients and healthy controls was performed. Clinical characteristics between the two groups were not significantly different (p > 0.05) except that the ages in control subjects were younger than the PHN patients (p < 0.05). Genotypes and allele frequencies are significantly different between the PHN patients and control subjects for the rs13361707 and rs10074991 polymorphisms (p < 0.05), but not for rs3792822 (p > 0.05). In addition, the CCG haplotype of rs13361707-rs3792822-rs10074991 correlated negatively with PHN occurrence, but TCA was positively correlated with PHN (p < 0.05). Our results indicate that PRKAA1 gene polymorphisms rs13361707 and rs10074991 were associated with a risk of PHN, and that the CCG haplotype of rs13361707-rs3792822-rs10074991 correlated negatively with PHN occurrence in haplotype analysis. TCA was positively associated with PHN in Chinese individuals.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study

Yang

Chen

et al. 2023

Front. Mol. Neurosci.

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Overview of Risk Factors for Esophageal Squamous Cell Carcinoma in China

Conway,

Wu,

Tian

2023

Cancers

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(1) Background: China has the highest esophageal squamous cell carcinoma (ESCC) incidence areas in the world, with some areas of incidence over 100 per 100,000. Despite extensive public health efforts, its etiology is still poorly understood. This study aims to review and summarize past research into potential etiologic factors for ESCC in China. (2) Methods: Relevant observational and intervention studies were systematically extracted from four databases using key terms, reviewed using Rayyan software, and summarized into Excel tables. (3) Results: Among the 207 studies included in this review, 129 studies were focused on genetic etiologic factors, followed by 22 studies focused on dietary-related factors, 19 studies focused on HPV-related factors, and 37 studies focused on other factors. (4) Conclusions: ESCC in China involves a variety of factors including genetic variations, gene–environment interactions, dietary factors like alcohol, tobacco use, pickled vegetables, and salted meat, dietary behavior such as hot food/drink consumption, infections like HPV, poor oral health, gastric atrophy, and socioeconomic factors. Public health measures should prioritize genetic screening for relevant polymorphisms, conduct comprehensive investigations into environmental, dietary, and HPV influences, enhance oral health education, and consider socioeconomic factors overall as integral strategies to reduce ESCC in high-risk areas of China.

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PRKAA1 rs13361707 C/T polymorphism confers decreased susceptibility to esophageal cancer: A case‐control study

Cited by 2 publications

References 23 publications

Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study

Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study

Overview of Risk Factors for Esophageal Squamous Cell Carcinoma in China

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