PRKAG2 and PRKAG3 genes in patients with Wolff-Parkinson-White syndrome: a literature review

Tolstokorova, Yu. A.; Nikulina, S. Yu.; Chernova, A. A.; Maksimov, V. N.; Makarov, Ya. A.

doi:10.15829/1560-4071-2023-5505

Russ J Cardiol

2023

DOI: 10.15829/1560-4071-2023-5505

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PRKAG2 and PRKAG3 genes in patients with Wolff-Parkinson-White syndrome: a literature review

Yu. A. Tolstokorova,

S. Yu. Nikulina,

A. A. Chernova

et al.

Abstract: Wolff-Parkinson-White syndrome (WPW) is a syndrome with early ventricular excitation due to the abnormal electrical conduction through an accessory atrioventricular pathway, and is usually accompanied by supraventricular tachycardia. There is a proven genetic component in the development of this syndrome. This review presents current literature data on the association of nucleotide sequence variants of the PRKAG2 and PRKAG3 genes in patients with WPW.

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2024

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THE ASSOCIATIVE ROLE OF THE rs121908987 POLYMORPHISM OF THE PRKAG2 GENE IN THE DEVELOPMENT OF WPW SYNDROME

Yu.A.,

S.Yu.,

A.A.

et al. 2024

Mediko-farmacevtičeskij žurnal "Pulʹs"

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The study of cardiac arrhythmias and conduction is one of the most urgent and important tasks, since these diseases are often the cause of sudden cardiac death. We assumed that the study of the contribution of "predictor genes" of heart rhythm and conduction disorders would expand knowledge about the etiology and pathogenesis of these diseases. Thus, the purpose of our research was to study the contribution of the rs121908987 polymorphism of the PRKAG2 gene to the development of WPW syndrome. Material and methods: 200 patients with VPU syndrome were examined, among them men n=97 [18:32.66;81]; women n=103 [18;47,92;83]. All patients underwent clinical, laboratory, somatometric, instrumental studies, as well as molecular genetic studies DNA isolation was performed by the standard phenol-chloroform method. Genotyping of the PRKAG2 gene was performed by PCR-PDRF analysis (polymerase chain reaction-polymorphism of restriction fragment lengths). Statistical data processing was carried out using the Excel application software package, Statistica for Windows 10.0, IBM SPSS 20.Differences in the frequency distribution of alleles and genotypes of the PRKAG2 gene between the groups were assessed using the χ2 criterion. The relative risk of disease for a specific allele or genotype was calculated as the odds ratio (OR). Results: a statistically significant predominance of the heterozygous GA genotype in patients with VPU syndrome, compared with those in the control group (8 and 2%, respectively; Table 1). There was also a statistically significant predominance of allele A carriers in the group of patients with VPU syndrome by 4%, compared with those in the control group (2%). The risk of developing PRKAG2 genotype GA syndrome, estimated by OSH, was 2.09 times higher (95% CI 1.88–2.32; p <0.001 compared with genotypes GG and AA, and in carriers of the A allele – 2.04 times higher (95% CI 1.90–2.19; p <0.001) compared with allele A (see Table 2). Conclusions: The results of the study confirmed the contribution of polymorphism rs121908987 of the PRKAG2 gene to the development of VPU syndrome.

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THE ASSOCIATIVE ROLE OF THE rs121908987 POLYMORPHISM OF THE PRKAG2 GENE IN THE DEVELOPMENT OF WPW SYNDROME

Yu.A.,

S.Yu.,

A.A.

et al. 2024

Mediko-farmacevtičeskij žurnal "Pulʹs"

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PRKAG2 and PRKAG3 genes in patients with Wolff-Parkinson-White syndrome: a literature review

Cited by 1 publication

References 24 publications

THE ASSOCIATIVE ROLE OF THE rs121908987 POLYMORPHISM OF THE PRKAG2 GENE IN THE DEVELOPMENT OF WPW SYNDROME

THE ASSOCIATIVE ROLE OF THE rs121908987 POLYMORPHISM OF THE PRKAG2 GENE IN THE DEVELOPMENT OF WPW SYNDROME

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