PRNP promoter polymorphisms are associated with BSE susceptibility in Swiss and German cattle

Haase, Bianca; Doherr, Marcus G.; Seuberlich, Torsten; Drögemüller, Cord; Dolf, G.; Nicken, Petra; Schiebel, Katrin; Ziegler, Ute; Groschup, Martin H.; Zurbriggen, Andreas; Leeb, Tosso

doi:10.1186/1471-2156-8-15

Cited by 74 publications

(85 citation statements)

References 28 publications

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“…For 12-bp indel locus, the allele 'I' frequency was higher than allele 'D' frequency in all studied breeds population, which was in contradiction to the previous reported results in US sires, Mongolia native and other cattle breeds population (Seabury et al 2004;Shimogiri et al 2010). Notably, allele 'I' at these two locus was higher in Chinese indigenous breeds, and previous reports revealed that the 12-bp insertion and 23-bp insertion polymorphisms all increased the resistance to BSE (Sander et al 2005;Juling et al 2006;Haase et al 2007;Xue et al 2008;Msalya et al 2010). Moreover, to date, occurrences of BSE have never been detected in China.…”

Section: Discussioncontrasting

confidence: 56%

The evaluation of 23-bp and 12-bp insertion/deletion within the PRNP gene and their effects on growth traits in healthy Chinese native cattle breeds

Yang

Zhang

Liu

et al. 2017

Journal of Applied Animal Research

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Polymorphisms in the prion protein gene (PRNP) have been linked with the occurrence of transmissible spongiform encephalopathies and the expression of some phenotypic traits in healthy animals including cattle. The aim of this study was to verify the 23-bp insertion/deletion (indel) within promoter region and the 12-bp indel within intron 1 of PRNP, as well as to evaluate their associations with growth traits. Two loci of PRNP were genotyped in 1558 healthy Chinese cattle sampled from 6 indigenous breeds. Moreover, phenotypic records for growth were used to find the relationship between PRNP polymorphisms and phenotypic performance. The results confirmed the occurrence of these two indel polymorphisms in the analysed breeds. Association analysis showed that the 23-bp indel was significantly related to the body length and heart girth in 18-months-old Nanyang cattle. The 12-bp indel was significantly related to the growth traits in three cattle breeds, such as the body weight in Xia'nan cattle, the daily gained weight in 12-months-old Nanyang cattle and the cannon circumference and rump length in Ji'an cattle. These findings indicated that these two indels may affect bovine growth traits, which could benefit to healthy cattle selection and breeding through marker-assisted selection.

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Section: Discussioncontrasting

confidence: 56%

The evaluation of 23-bp and 12-bp insertion/deletion within the PRNP gene and their effects on growth traits in healthy Chinese native cattle breeds

Yang

Zhang

Liu

et al. 2017

Journal of Applied Animal Research

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“…There is also as yet no other PrP protein polymorphism in cattle that can be associated with BSE. However the recently discovered PrP promoter polymorphisms may be associated with susceptibility to BSE in British and German herds [41,56]. The main effect is with the 12 bp deletion allele (12del).…”

Section: Bse In Cattlementioning

confidence: 99%

PrPgenetics in ruminant transmissible spongiform encephalopathies

2008

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-Scrapie, bovine spongiform encephalopathy (BSE), and chronic wasting disease (CWD) are prion diseases in ruminants with considerable impact on animal health and welfare. They can also pose a risk to human health and control is therefore an important issue. Prion protein (PrP) genetics may be used to control and eventually eradicate animal prion diseases. The PrP gene in sheep and other representatives of the order Artiodactyles has many polymorphisms of which several are crucial determinants of susceptibility to prion diseases, also known as transmissible spongiform encephalopathies (TSE). This review will present the current understanding of PrP genetics in ruminants highlighting similarity and difference between the species in the context of TSE.

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“…Previous reports revealed that the 12-bp insertion and 23-bp insertion polymorphisms all increased the resistance to BSE, while the 12-bp deletion polymorphism resulted in the increasing expression of PrP, and which resulted in higher susceptibility to prion diseases (Sander et al 2005;Juling et al 2006;Haase et al 2007;Xue et al 2008). The expression level of PrP had a negative relationship with the resistance to BSE, when the expression level of PrP was increasing, while the resistance would be decreasing.…”

Section: Discussionmentioning

confidence: 98%

“…Until now, many polymorphisms of PRNP had been identified in cattle. Previous reports have shown that several PRNP polymorphisms were associated with resistance to BSE in cattle (Sander et al 2005;Haase et al 2007;Kashkevich et al 2007). In particular, a 23-bp in-del polymorphism within the PRNP promoter region and a 12-bp in-del polymorphism within intron 1 seemed to affect the binding sites for the transcriptional factors RP58 and SP1, respectively, and might influence PRNP expression (Sander et al 2004;Sander et al 2005;Xue et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Effects of PRNP polymorphisms on sperm quality traits in Chinese Holstein bulls

Gao¹,

Song

et al. 2013

Journal of Applied Animal Research

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To analyze the associations of polymorphisms of prion protein gene (PRNP) with reproduction traits in Chinese Holstein bulls, significant statistical results are found in sperm quality traits between individuals with different 23-bp in-del, 12-bp in-del, and 24-bp in-del polymorphic genotypes. The individuals with 12-bp and 23-bp insertion polymorphisms had lower ejaculation volume, the number of straw frozen sperm once ejaculation and the number of straw per year than that of deletion polymorphisms at this two sites(p < 0.05). The individuals with 24-bp in-in genotype had lower number of straw per year than that of 24-bp in-del genotype (p < 0.050). These results showed the trend that resistant cattle PRNP genotypes possibly had negative effects on production traits in bulls. Therefore, this study provided possible molecular markers for bull breeding in resistance selection.

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PRNP promoter polymorphisms are associated with BSE susceptibility in Swiss and German cattle

Cited by 74 publications

References 28 publications

The evaluation of 23-bp and 12-bp insertion/deletion within the PRNP gene and their effects on growth traits in healthy Chinese native cattle breeds

The evaluation of 23-bp and 12-bp insertion/deletion within the PRNP gene and their effects on growth traits in healthy Chinese native cattle breeds

PrPgenetics in ruminant transmissible spongiform encephalopathies

Effects of PRNP polymorphisms on sperm quality traits in Chinese Holstein bulls

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