Pro- and anti-inflammatory cytokine expression in carp blood and head kidney leukocytes exposed to cyanotoxin stress – An in vitro study

Rymuszka, Anna; Adaszek, Łukasz

doi:10.1016/j.fsi.2012.05.021

Cited by 86 publications

(33 citation statements)

References 40 publications

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“…In fish, the immune status was closely associated with the inflammation [2]. Inflammation was initiated and regulated by inflammatory cytokines [48,49]. In mammals, the over-production of the pro-inflammatory cytokines TNF-a and IL-8 have often been correlated with inflammation [50,51].…”

Section: Discussionmentioning

confidence: 99%

Intestinal immune function, antioxidant status and tight junction proteins mRNA expression in young grass carp ( Ctenopharyngodon idella ) fed riboflavin deficient diet

Chen

Feng²,

Jiang

et al. 2015

Fish & Shellfish Immunology

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Section: Discussionmentioning

confidence: 99%

Intestinal immune function, antioxidant status and tight junction proteins mRNA expression in young grass carp ( Ctenopharyngodon idella ) fed riboflavin deficient diet

Chen

Feng²,

Jiang

et al. 2015

Fish & Shellfish Immunology

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“…In teleostean fishes, such as carp and rainbow trout, the expression of interleukin 1 β (IL-1 β ) mRNA can be stimulated by lipopolysaccharide alone or in combination with cortisol [39–41]. On the contrary, some toxic compounds as cyanotoxin anatoxin-a, for example, significantly inhibited proinflammatory (IL-1 β and TNF- α ) cytokines and induced anti-inflammatory (IL-10 and TGF- β ) cytokines in common carp [42]. …”

Section: Discussionmentioning

confidence: 99%

Effects of Subchronic Exposure toN,N-Diethyl-m-toluamide on Selected Biomarkers in Common Carp (Cyprinus carpioL.)

Slaninova

Modrá

Hostovský

et al. 2014

BioMed Research International

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DEET (N,N-diethyl-m-toluamide) is the most common active ingredient in the insect repellents commonly detected in European groundwater. The aim of this study was to investigate the effect of subchronic DEET exposure on biochemical and haematological parameters, antioxidant enzymes, including catalase, glutathione peroxidase, glutathione reductase, and glutathione S-transferase, and the amount of thiobarbituric acid reactive substances (TBARS) in common carp (Cyprinus carpio L.). Two specific proinflammatory and anti-inflammatory cytokine genes were selected to assess an immunological status of the fish. Fish were exposed for 28 days to three concentrations of DEET (1.0 µg/L, 0.1 mg/L, and 1.0 mg/L) where 1 µg/L is corresponding to the concentration found in the environment. DEET had a significant (P < 0.05) effect on increased RBC, decreased mean corpuscular volume (MCV), and mean corpuscular haemoglobin value (MCH) compared to control groups in the concentration of 1 mg/L. A significant decline (P < 0.05) in triacylglycerols (TAG) in plasma was found in the concentration of 1 mg/L compared to the control groups. The parameters of oxidative stress in tissues of common carp were weekly affected and immunological parameters were not affected.

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“…In fish, the cytokines include pro-inflammatory cytokines, such as TNF-a and IL-8, and antiinflammatory cytokines, such as IL-10 and TGF-b [71]. In mammals, the down-regulation of TNF-a gene expression or inhibition of IL-8 release ameliorated tissue damage caused by the overreaction of the inflammatory response [72,73].…”

Section: Trp Improved the Innate Immunity Attenuated The Inflammatormentioning

confidence: 99%

Dietary tryptophan modulates intestinal immune response, barrier function, antioxidant status and gene expression of TOR and Nrf2 in young grass carp (Ctenopharyngodon idella)

Wen

Feng

Jiang

et al. 2014

Fish & Shellfish Immunology

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Pro- and anti-inflammatory cytokine expression in carp blood and head kidney leukocytes exposed to cyanotoxin stress – An in vitro study

Cited by 86 publications

References 40 publications

Intestinal immune function, antioxidant status and tight junction proteins mRNA expression in young grass carp ( Ctenopharyngodon idella ) fed riboflavin deficient diet

Intestinal immune function, antioxidant status and tight junction proteins mRNA expression in young grass carp ( Ctenopharyngodon idella ) fed riboflavin deficient diet

Effects of Subchronic Exposure toN,N-Diethyl-m-toluamide on Selected Biomarkers in Common Carp (Cyprinus carpioL.)

Dietary tryptophan modulates intestinal immune response, barrier function, antioxidant status and gene expression of TOR and Nrf2 in young grass carp (Ctenopharyngodon idella)

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