Pro- and antioxidant properties of uracil derivatives

Murinov, Yu. I.; Grabovskii, S. A.; Kabal'nova, N. N.

doi:10.1007/s11172-019-2505-4

Cited by 14 publications

(11 citation statements)

References 67 publications

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“…The mixture was filtered, washed, and purified further with ethanol to recrystallization. Table-3 contains a list of a variety of physical properties of compounds (11)(12)(13)(14)(15) as well as FTIR spectral data.…”

Section: Synthesis Of 13-dimethyl-6-amino Acetamide[2-(4-substituted ...mentioning

confidence: 99%

“…Table 3. the physical properties as well as the FTIR spectral data cm-1 of the compounds that were produced (11)(12)(13)(14)(15).…”

Section: Synthesis Of 13-dimethyl-6-amino Acetamide[2-(4-substituted ...mentioning

confidence: 99%

“…as a result of their ease of synthesis, uracil derivatives are regarded as promising compounds in drug discovery. The pyrimidine core is an important pharmacophore moiety of biologically active natural and synthetic compounds that compete for the same binding sites [15] the most conmen biological activities of uracil derivatives in the last years application Antioxidan t [2], Anti-flamatory [16], Anticaner [17], Anti-leukemia [18], Antibacterial [19,20], anti-tumour [21], anti-angiogenesis [22] and Anti-diabetic [23].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, identification of some new tetrazoline, thiazolidin-4-one and imidazolidin-4-one derivatives and evaluation anticancer of their molecular docking and anti-oxidant experimental

AL-tamimi¹,

Al-Majidi²

2023

3C TIC

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In this study, a new series of 1,3-dimethyl-6-(amino aceto hydrazine) pyrimidine-2,4- dione-6-yl with 4-substituted benzyldehyde, The compound (1-5) was synthesized in a single pot that cyclization by the addition of sodium azide, 2-mercapto acid & 2-amino acetic acid to produce five-membered heterocyclic rings includes: tetrazoline-1yl (6-10), thiazolidin-4-one (11-15) and imidazolidin-4-one (16-20) derivatives respectively. These compounds were characterized using spectral methods [FTIR and 1HNMR, 13C-NMR for some of them] evaluations, measurements, and analyses of their physical qualities. Each molecule was evaluated for antioxidant activity in vitro to use the DPPH and phosphomolybdenum methods. When compared to the standard drug Ascorbic acid, (1-20) demonstrated promising antioxidant activity among the bioactive molecules synthesized. Furthermore, molecular docking against, substances showed superiority over the standard medication Exemestane in tests of the Aromatase enzyme.

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Section: Synthesis Of 13-dimethyl-6-amino Acetamide[2-(4-substituted ...mentioning

confidence: 99%

“…Table 3. the physical properties as well as the FTIR spectral data cm-1 of the compounds that were produced (11)(12)(13)(14)(15).…”

Section: Synthesis Of 13-dimethyl-6-amino Acetamide[2-(4-substituted ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis, identification of some new tetrazoline, thiazolidin-4-one and imidazolidin-4-one derivatives and evaluation anticancer of their molecular docking and anti-oxidant experimental

AL-tamimi¹,

Al-Majidi²

2023

3C TIC

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“…1 These compounds, most of which are modified uracil molecules, exhibit a broad spectrum of pharmacological activities, including antiviral, anticancer, immunomodulatory, and others. 2 Uracil derivatives with C5-substituted aryl or heteroaryl motifs are a unique class of promising compounds in drug discovery due to their extraordinary antivirus activities, making them successful candidates used in clinical practice. For example, the simple 5phenyl-2′-deoxyuridine 1 was synthesized to target herpes simplex virus type-1 through a competitive phosphorylation by the viral thymidine kinase (Figure 1).…”

Section: ■ Introductionmentioning

confidence: 99%

“…The pyrimidine core has long been recognized as an important pharmacophore moiety in natural and synthetic biologically active compounds competing for their nucleoside/nucleobase counterparts . These compounds, most of which are modified uracil molecules, exhibit a broad spectrum of pharmacological activities, including antiviral, anticancer, immunomodulatory, and others . Uracil derivatives with C5-substituted aryl or heteroaryl motifs are a unique class of promising compounds in drug discovery due to their extraordinary antivirus activities, making them successful candidates used in clinical practice.…”

Section: Introductionmentioning

confidence: 99%